Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

Kasztelewicz, Beata; Janiszewska, Katarzyna; Burzyńska, Julia; Szydłowska, Emilia; Migdał, Marek; Dzierżanowska-Fangrat, Katarzyna

doi:10.1371/journal.pone.0249550

Cited by 16 publications

(22 citation statements)

References 12 publications

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“…Population-based serosurveys measuring anti-SARS-CoV-2 antibodies offer one method for approximating infection rates and monitoring the progress of the epidemic [ 4 ]. By identifying individuals who have established anti-viral antibodies, immunoassay, such as enzyme-linked immunosorbent assay (ELISA), can provide a more thorough understanding of the SARS-CoV-2 prevalence [ 5 ]. In fact, the current study is important to observe and trace COVID-19 incidence and recognize the frequency of or non-reported COVID-19 infections individuals in the community.…”

Section: Introductionmentioning

confidence: 99%

Assessment of SARS-CoV-2 Anti-Spike IgG Antibody in Women and Children in Madinah, Saudi Arabia: A Single-Center Study

Mahallawi

Ibrahim

Aljohani

et al. 2021

IJERPH

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Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Information on the prevalence of SARS-CoV-2 antibodies in women and children in Madinah has been limited. The current study aimed to evaluate SARS-CoV-2 IgG seropositivity among women and children at Madinah Maternity and Children’s Hospital. Methods: In this cross-sectional study, 579 participants were recruited between January and April 2021 from Madinah Maternity and Children’s Hospital, Saudi Arabia. Data concerning age, sex (for children), blood group, and height and weight (for women) were collected from the hospital database. SARS-CoV-2 anti-spike (anti-S) IgG antibodies were detected by enzyme-linked immunosorbent assay (ELISA). Results: Over 58% of children (n = 195), including 60% of children ≤1 year (n = 75), and 50.2% (n = 124) of women were SARS-CoV-2 anti-S IgG seropositive. Significantly higher anti-S IgG levels were observed in children than in women (0.78 ± 1.05 vs. 0.65 ± 0.98, p = 0.008). Compared with women, children had higher odds of high SARS-CoV-2 anti-S IgG levels (odds ratio: 1.41; 95% confidence interval: 1.01–1.97; p = 0.041). No significant associations were observed for anti-S IgG levels with age in women or children or with body mass index among women. Conclusion: Non-reported COVID-19 infections were more prevalent among children than women, and non-reported COVID-19 infections children represent a viral transmission risk; therefore, increased screening, especially among school-aged children, may represent an important COVID-19 preventive control measure.

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Section: Introductionmentioning

confidence: 99%

Assessment of SARS-CoV-2 Anti-Spike IgG Antibody in Women and Children in Madinah, Saudi Arabia: A Single-Center Study

Mahallawi

Ibrahim

Aljohani

et al. 2021

IJERPH

View full text Add to dashboard Cite

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“…There have been several studies examining the prevalence of SARS-CoV-2 and the seroprevalence of IgM/IgG antibodies in HCWs compared to community levels, and results are varied [ 4 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Though there have been fewer studies of pediatric HCWs to date, rates of positive serology in pediatric HCWs have consistently been found to be lower or equal to those measured in the general population, with the reported range of positive serology ranging from 0–16.9% [ 5 , 6 , 7 , 8 , 9 , 19 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although the potential for increased exposure to SARS-CoV-2 among healthcare workers (HCWs) has led to numerous serologic studies, the pediatric HCW population remains somewhat less well surveyed [ 4 , 5 , 6 , 7 , 8 , 9 ]. Pediatric HCW are in general exposed to a large variety of infectious diseases, and during the COVID-19 pandemic, at increased risk for both known and unknown exposure to SARS-CoV-2 given the varied presentation of COVID-19 in children.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Serology Testing in an Asymptomatic, At-Risk Population: Methods, Results, Pitfalls

Heyming

Bacon

Lara

et al. 2021

Infectious Disease Reports

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The primary aim of this study was to determine the seroprevalence of SARS-CoV-2 antibodies in a population of pediatric healthcare workers (HCWs). This study was conducted 14 May–13 July 2020. Study participants included pediatric HCWs at a pediatric hospital with either direct patient contact or close proximity to patient-care areas. SARS-CoV-2 antibodies were assessed via the Wytcote Superbio SARS-CoV-2 IgM/IgG Antibody Fast Detection Kit and the Abbott Architect SARS-CoV-2 IgG assay. Participants underwent RT-PCR testing upon entry to the study and following rapid IgM+/IgG+ results; respiratory panel PCR (RP-PCR) was performed following IgM+ results. A total of 57 of 289 (19.7%) of participants demonstrated positive serology as assessed by the Wytcote rapid kit (12 on Day 1 and 45 throughout the study). However, only one of these participants demonstrated IgG+ serology via the Abbott assay. Two participants tested SARS-CoV-2+ via RT-PCR testing. One individual was adenovirus+ and enterovirus/rhinovirus+. In our study population, we observed a seroprevalence of SARS-CoV-2 antibodies of 0.35%. The lack of concordance between antibody tests suggests that the Wytcote rapid test kit may not be of use as a screening tool. However, the feasibility of the overall process indicates that a similar methodology may have potential for future epidemiologic surveillance.

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“…Considering the spatial conditions in hospital waiting rooms, it appears reasonable that the risk of viral infection is elevated due to the relatively close contact to possible SARS-CoV-2 infected patients. Furthermore, direct contact to healthcare workers may also imply an increased risk for viral transmission: Shields et al report a point prevalence of asymptomatic, SARS-CoV-2 PCR-positive healthcare works (HCW) of 2.4% and Kasztelewitz et al found, that more than 50% of the HCW, who had been tested positive for SARS-CoV-2 antibodies, denied any clinical symptoms in the past weeks prior testing, illustrating that these HCW had been asymptomatic but possibly infectious at a time [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Low incidence of COVID-19 in a prospective cohort of patients with liver cirrhosis and hepatocellular carcinoma treated at a tertiary medical center during the 2020 pandemic

et al. 2021

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Background and aims Patients with liver cirrhosis (LC) are considered to be at increased risk for mortality when acquiring SARS-CoV-2 infection and subsequently developing Corona Virus Disease 2019 (COVID-19). During the COVID-19 pandemic, hospitals are regarded as sites with increased risk of infection. Therefore, patient contacts are often limited to urgent indications, which could negatively affect disease monitoring. However, data regarding actual infection rates in cirrhotic patients is limited. The aim of this prospective study was to assess the incidence of COVID-19 in patients with LC with/without hepatocellular carcinoma (HCC) with physical presentation at our University Medical Center. Methods Patients were enrolled between 1st April and 30th June 2020 at the University Medical Center Hamburg-Eppendorf, Germany. Symptoms of upper airway infection at baseline and presence of SARS-CoV-2 antibodies (IgG/IgM/IgA) were assessed at baseline and follow-up (FU) using an Electro-chemiluminescence immunoassay (Roche Elecsys). FU visits, including liver function test, clinical assessment and symptom questionnaire, were conducted after 6–8 weeks (FU-1) and 6 months (FU-2). Prior to inclusion of the first patient, obligatory face masks and personal distance were implemented as protective measures. Results A total of 150 patients were enrolled, 23% (n = 35) also had diagnosis of HCC (median age: 64 years, range: 19–86), 69% were male. Liver function according to Child-Pugh score (CPS) was: CPS A: 46% (n = 62); CPS B: 37% (n = 50); CPS C: 17% (n = 23). Clinical symptoms indicating upper airway infection were present in 53% (n = 77): shortness of breath (n = 40) and coughing (n = 28) were the most frequent. For the 150 patients enrolled, 284 outpatient visits were registered and 33 patients were admitted to the University Medical Center during the follow-up period. After a median of 52 days, n = 110 patients completed FU-1 and n = 72 completed FU-2 after a median of 6.1 months. Only in one patient, an 80-year-old man with stable liver function (CPS A) and advanced HCC, SARS-CoV-2 antibodies were detected at baseline and FU-1, while antibody testing was negative in the remaining patients at baseline, FU-1 and FU-2. Conclusion The incidence of COVID-19 at our tertiary medical center during the pandemic was low in LC and HCC patients, when simple protective measures were implemented. Therefore, a routine care for patients with chronic liver diseases does not increase the risk of SARS-CoV-2 infection and should be maintained with protective measures.

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Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

Cited by 16 publications

References 12 publications

Assessment of SARS-CoV-2 Anti-Spike IgG Antibody in Women and Children in Madinah, Saudi Arabia: A Single-Center Study

Assessment of SARS-CoV-2 Anti-Spike IgG Antibody in Women and Children in Madinah, Saudi Arabia: A Single-Center Study

SARS-CoV-2 Serology Testing in an Asymptomatic, At-Risk Population: Methods, Results, Pitfalls

Low incidence of COVID-19 in a prospective cohort of patients with liver cirrhosis and hepatocellular carcinoma treated at a tertiary medical center during the 2020 pandemic

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