Introduction A validated assessment of pruritus intensity is an important but still difficult clinical problem due to a subjective nature of this sensation. Objective The aim of this study was the creation and validation of new itch severity questionnaire assessing pruritus intensity. Material and Methods A total of 148 patients with pruritic dermatoses were asked to assess pruritus intensity using 12-Item Pruritus Severity Score (12-PSS) and Visual Analogue Scale (VAS). Patients were also asked to complete the Dermatology Life Quality Index (DLQI) and Hospitality Anxiety and Depression Scale (HADS). Test-retest comparison of 12-PSS was conducted in 102 subjects who completed the itch questionnaire twice with the 3- to 5-day interval. Results We have created the 12-PSS assessing pruritus intensity (two questions), pruritus extent (one question) and duration (one question), influence of pruritus on concentration and patient psyche (four questions), and scratching as a response to pruritus stimuli (four questions). A maximum scoring was 22 points. The results showed strong consistency (Cronbach α coefficient 0.81). A significant correlation was observed with VAS (r = 0.58, p < 0.001) and quality of life level according to DLQI (r = 0.53, p < 0.001). Test-retest comparison in 102 subjects revealed a satisfactory reproducibility of achieved results (ICC = 0,72). Conclusions The newly developed pruritus severity questionnaire may be used in daily clinical practice in the future.
The objective of this study was to investigate free amino acids composition of Polish honeys with different botanical origin. Honeys (n=18) with dominant buckwheat, raspberry, acacia, heather and goldenrod pollen, and honeydew honey were analysed. For determination of free amino acids liquid chromatography methods were applied. Identifi cation of 25 free amino acids was performed. Considerable variation in the total content of free amino acids ranging from 186.19 mg/kg to 921.08 mg/kg was stated. The dominant free amino acid in all types of honey was proline with the highest detected amount in one sample of heather honey 387.88 mg/kg. As an indicator of honeys with predominant raspberry and buckwheat pollen high concentrations of aspartic acid and asparagine (accounting for ca. 20 and more mg/kg) are suggested. The content of tyrosine, leucine, isoleucine and valine ranging from 10 to ca. 20 mg/kg was characteristic of raspberry and at concentrations above 20 mg/kg of buckwheat honeys. The cluster analysis showed the closest correlation between heather and goldenrod honeys. The largest distance was stated between buckwheat and all other honey groups. The results show that it was impossible to clearly distinguish the botanical origins of Polish honey samples based on their amino acid composition.
The crisis related to the COVID-19 pandemic influenced food security and nutrition through both direct and indirect pathways. This ranged from short-term to long-term impacts, not only on health but also on food systems and thus on nutrition. This study aimed to identify how the observed constraints affected the food intake of populations across the globe. Here, special attention was paid to the consumption of vegetables and legumes and the diversity within these food groups. An online survey on Food and COVID-19 was conducted using a semi-structured questionnaire translated into several languages. Binary logistic regression models and Poisson regression models were calculated to evaluate changes in consumption patterns and to test potential determinants for the changes. For more detailed information on reasons for changes open ended questions were analysed qualitatively. Time spend at home, working from home, and mental stress were important drivers for changes in dietary intake according to the 1,042 respondents included in this analysis. The participants observed a change in food quantity (38%) and vegetable intake (27%). No changes were observed for the number of vegetable groups consumed, while significant reductions in diversity were detected within all vegetable groups. Moreover, associations between the number of consumed vegetable types during the COVID-19 pandemic and income regions as well as gender were found. The regression analysis showed that the level of decrease in vegetable diversity in the different vegetable groups were often depending on educational and occupational status, gender and household environment. Changes in food prices were related to changes in vegetable intake per se, overall vegetable diversity, and diversity within the provitamin A rich vegetable group. Food systems are not static and are transitioning quickly as could be observed during the Covid-19 pandemic. There is a need for a nutrition strategy to strengthen the resilience of vulnerable households to consume a diverse diet in adequate amount even in times of a pandemic.
Data on the prevalence of the SARS-CoV-2 antibody in healthcare workers (HCWs) is scarce, especially in pediatric settings. The purpose of this study was to evaluate SARS-CoV-2 IgG-positivity among HCWs of a tertiary pediatric hospital. In addition, follow-up of the serological response in the subgroup of seropositive HCWs was analysed, to gain some insight on the persistence of IgG antibodies to SARS-CoV-2. We performed a retrospective analysis of voluntary SARS-CoV-2 IgG testing, which was made available free of charge to HCWs of the Children’s Memorial Health Institute in Warsaw (Poland). Plasma samples were collected between July 1 and August 9, 2020, and tested using the Abbott SARS-CoV-2 IgG assay. Of 2,282 eligible participants, 1,879 (82.3%) HCWs volunteered to undergo testing. Sixteen HCWs tested positive for SARS-CoV-2 IgG, corresponding to a seroprevalence of 0.85%. Among seropositive HCWs, three HCWs had confirmed COVID-19. Nine (56.3%) of the seropositive HCWs reported neither symptoms nor unprotected contact with confirmed SARS-CoV-2 cases in the previous months. A decline in the IgG index was observed at a median time of 86.5 days (range:84‒128 days) after symptom onset or RT-PCR testing. Further studies are necessary to elucidate the duration of persistence of anti-SARS-CoV-2 antibodies, as well as the correlation between seropositivity and protective immunity against reinfection. Regardless of the persistence of antibodies and their protective properties, such low prevalence indicates that this population is vulnerable to a second wave of the COVID-19 pandemic.
Epidemiological research has identifi ed a relationship between infant birth weight, maternal physical activity and nutrition with likelihood of developing future diseases such as hypertension, diabetes, obesity, infectious, allergic, and autoimmune diseases, as well as death resulting from ischemic heart disease, relating
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