Comparative study on the application of capillary liquid chromatography and capillary electrochromatography for investigation of enantiomeric purity of the contraceptive drug levonorgestrel

Chankvetadze, Bezhan; Kartozia, Irma; Yamamoto, Chiyo; Okamoto, Yoshio; Blaschke, Gottfried

doi:10.1016/s0731-7085(02)00533-2

Cited by 55 publications

(28 citation statements)

References 15 publications

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“…Chankvetadze et al [48] employed cellulose tris(3,5-dichlorophenylcarbamate)-coated silica particles as CSPs for a critical comparison of CLC and CEC for the determination of the enantiomeric purity in a commercial sample of the contraceptive drug levonorgestrel and its pharmaceutical formulation. CSPs with varying surface coverage of the SO (5-25%) were fabricated and several experiments on the sample loading conditions were performed.…”

Section: Particle-packed Stationary Phasesmentioning

confidence: 99%

Recent accomplishments in the field of enantiomer separation by CEC

Preinerstorfer

Lämmerhofer

2007

Electrophoresis

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Recent accomplishments in the field of enantiomer separation by CECThe present review intends to summarize recent developments in the field of enantioselective separations and analysis by CEC. It covers studies published in English language in common peer-reviewed journals within the period between 2003 and 2006. Both, methods making use of chiral mobile phase additives as well as chiral stationary phases for electrochromatographic enantiomer separations, are reviewed. Achievements that have been made on the various column technologies, such as open-tubular, particle-packed, inorganic, organic and particle-fixed (hybrid-type) monolithic as well as molecularly imprinted polymer phases, are discussed.

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Section: Particle-packed Stationary Phasesmentioning

confidence: 99%

Recent accomplishments in the field of enantiomer separation by CEC

Preinerstorfer

Lämmerhofer

2007

Electrophoresis

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“…Chankvetadze and co-workers [157] compared CLC and CEC for the determination of the chiral purity of the contraceptive drug levonorgestrel using the same column packed with cellulose tris(3,5-dichlorophenylcarbamate) coated on silica gel as chiral stationary phase. While the separation selectivity was comparable for both techniques, peak efficiency and, consequently, resolution were higher in CEC.…”

Section: Enantioseparation Of Drugs In Pharmaceuticals and Biologicalmentioning

confidence: 99%

Pharmaceutical and biomedical applications of chiral capillary electrophoresis and capillary electrochromatography: An update

Scriba¹

2003

Electrophoresis

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Pharmaceutical and biomedical applications of chiral capillary electrophoresis and capillary electrochromatography: An updateCapillary electrophoresis is often considered an ideal method for the chiral analysis of compounds due to the high separation power of the technique and has therefore found widespread acceptance for the analysis of drugs and pharmaceuticals. In contrast, capillary electrochromatography is still more or less in an infancy state searching for its place among the analytical separation techniques although interesting applications have been published. The present review summarizes recent developments and applications of chiral pharmaceutical analysis by electromigration techniques published in 2002 and early 2003.

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“…Chankvetadze et al [92] compared CEC with capillary LC for the determination of the enantiomeric purity of levonorgestrel, using the same cellulose-based stationary phase. Although with CEC higher separation efficiencies were obtained, low levels of enantiomeric impurity were not more easily detected than with capillary LC.…”

Section: Steroidsmentioning

confidence: 99%

Recent applications in capillary electrochromatography

2003

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The most recent and important applications in capillary electrochromatography (CEC) are summarized, covering literature published since May 2001. A selection of new developments in stationary phases for CEC is highlighted, and enantiomeric separations and chiral stationary phases are discussed. Also, CEC applications of biological molecules, pharmaceuticals, and applications in the field of industrial and environmental analysis are summarized. For this review three modes of CEC were taken into account, i.e., packed-column CEC, CEC using monolith technology, and open-tubular CEC.

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Comparative study on the application of capillary liquid chromatography and capillary electrochromatography for investigation of enantiomeric purity of the contraceptive drug levonorgestrel

Cited by 55 publications

References 15 publications

Recent accomplishments in the field of enantiomer separation by CEC

Recent accomplishments in the field of enantiomer separation by CEC

Pharmaceutical and biomedical applications of chiral capillary electrophoresis and capillary electrochromatography: An update

Recent applications in capillary electrochromatography

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