Comparative study of the effect on the neuroendocrine-immune complex and metabolism of drinking monotherapy with Naftussya water and therapy supplemented with “Myroslava” and “Khrystyna” mineral waters

Abstract

Background. Earlier in an experiment on rats, we showed that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have neuroendocrine and metabolic effects significantly different from daily water. Adhering to the principle "From experiment to clinic", we continued research in this direction with the participation of patients of the resort. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets resort. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, however, 11 men additionally drank water "Khrystyna", and the other 11 men - water "Myroslava". The subject of the study were the parameters of the neuroendocrine-immune complex and metabolism. Results. The complex balneotherapy by interval use of sulfate-chloride sodium-magnesium mineral waters with Naftusya water causes significant changes in the constellation of neuroendocrine, metabolic and immune parameters, which are different from the effects of Naftusya water monotherapy. Own effects of mineral waters are estimated by modeling. In general, the effects are physiologically favorable and have a normalizing nature. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets resort have favorable neuroendocrine, metabolic and immune effects on patients with chronic cholecystitis and pyelonephritis.

Peculiarities of modulating effects of “Myroslava” and “Khrystyna” mineral waters on neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa

“…Earlier we found effects on the neuroendocrine-immune complex and metabolism, which are common to the mineral waters "Myroslava" and "Khrystyna", instead different from the effects of Naftussya water [6,12,13]. The purpose of this article is to find the specific effects of these waters.…”

“…The examination was performed twice, before and after a 7-10-day course of balneotherapy. Half of the patients received bioactive water Naftussya (3 mL/kg one hour before meals three times a day) and sulfate-chloride sodium-magnesium mineral water "Myroslava" (in half an hour in the same dose), and the other half -Naftussya and "Khrystyna" waters [12].…”

“…The day before, daily urine was collected, in which was determined the concentration of electrolytes and nitric metabolites [12] as well as bacteriuria, erythrocyturia and leukocyturia. The same metabolic parameters were determined in plasma as well as glucose and lipids [12].…”

“…We determined content in plasma major hormones of adaptation: Cortisol, Testosterone, Calcitonin and Triiodothyronine as well as Parathyroid activity evaluated by coefficient (Сар•Pu/Cau•Рр) 0,25 [12].…”

“Myroslava” and “Khrystyna” drinking mineral waters modulate the state of neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa

“…Adhering to the principle "Ex experimento ad clinic", we continued research in this direction with the participation of patients of the resort. We showed that these mineral waters have favorable effects on metabolic, HRVs, EEGs, endocrine and immune parameters [8,9]. This article presents an integrated assessment of previously identified effects.…”