Comparative Study of Serum Malondialdehyde Levels as a Marker of Oxidative Stress in Patients of Pregnancy induced Hypertension and Controls

Bhale, Dhananjay V.; Hivre, Manjusha; Mahat, Roshan Kumar; Bujurge, Ashlesha A.

doi:10.5005/jp-journals-10036-1010

Cited by 13 publications

(10 citation statements)

References 5 publications

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“…In control group of pregnant women, there was no statistical significant difference found in TBARS values; pregnant women with PIH with US findings: enough and more amniotic fluid and pregnant women with PIH with US findings: less amniotic fluid, and TBARS mean value in control group of pregnant women with US findings: less amniotic fluid amounted 13.72 µmol, low values interval. Similar results are presented by Bhale DV et al in their study ( 22 ).…”

Section: Discussionsupporting

confidence: 92%

Correlation of Oxidative Stress Markers with Ultrasound and Cardiotocography Parameters with Hypertension Induced Pregnancy

Draganović¹,

Lucic²,

Jojić³

et al. 2017

Acta Inform Med

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Introduction:Pregnancy induced hypertension (PIH), especially preeclampsia, is a state of extremely increased oxidative stress (OS), due to decrease of antioxidant capacity in comparison to normotensive pregnant women. The consequences of increased state of oxidative stress with hypertension disorder in pregnancy are disorder of placental blood flow, intrauterine hypoxia of the fetus and disturbance in transfer of O2 manifested as pathological ultrasound (US) parameters (amount of amniotic fluid and biophysical profile of fetus) and cardiotocography parameters (CTG).Aim:The aim of this research is to analyze correlation of TBARS oxidative stress markers with ultrasound parameters of pregnancy course and cardiotocography parameters in pregnant women with PIH.Patients and methods:Research has been performed at the Clinic of Gynecology and Obstetrics, University Clinical Centre of the Republic of Srpska. It covered 200 pregnant women, 100 of them with PIH and 100 healthy pregnant women, at gestational age from 28 to 40 weeks. All pregnant women were analyzed for US parameters of pregnancy course and CTG records as well as oxidative stress biomarker, values of Thiobarbituric Acid (TBARS).Results:Pregnant women with PIH had high statistical significant (pre)pathological CTG records and US- biophysical profile, less amount of amniotic fluid and delivered in lower gestation compared to healthy pregnant women. TBARS high values are statistical high significant frequent with pregnant women with PIH, who had pathological and pre-pathological biophysical profile and CTG records, as well as with US less amount of amniotic fluid (p<0.01). The highest TBARS values were presented with PIH pregnant women and US of less amount of amniotic fluid 42.3 µmol.Conclusion:There is statistical strong connection between TBARS values, being used as oxidative stress markers, and diagnostic methods used in PIH diagnostics, ultrasound (amount of amniotic fluid, fetus biophysical profile) and cardiotocography recording. TBARS could also be significant in clinical application for assessment of pregnant women with PIH in order to make decisions on pregnancy termination period.

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Section: Discussionsupporting

confidence: 92%

Correlation of Oxidative Stress Markers with Ultrasound and Cardiotocography Parameters with Hypertension Induced Pregnancy

Draganović¹,

Lucic²,

Jojić³

et al. 2017

Acta Inform Med

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“…Oxidative stress could have a significant role in generation of pregnancy induced hypertension (PIH), since it starts damage of endothelium of placenta vascularization and immune response ( 19 , 20 ). Bhale DV et al also concluded in their study that pregnancy induced hypertension (PIH) is a state of extreme increase of oxidative stress and lipid peroxidation ( 21 ).…”

Section: Discussionmentioning

confidence: 98%

Oxidative Stress Marker and Pregnancy Induced Hypertension

Draganović

Lucic

Jojić

2016

Med Arh

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Background:Pregnancy induced hypertension (PIH) is a state of extremely increased oxidative stress. Hence, research and test of role and significance of oxidative stress in hypertensive disturbance in pregnancy is very important.Aim:Aims of this research were to determine a level of thiobarbituric acid reactive substance (TBARS) as oxidative stress marker in blood of pregnant woman with pregnancy induced hypertension and to analyze correlation of TBARS values with blood pressure values in pregnancy induced hypertensive pregnant women.Patients and methods:Research has been performed at the Clinic of Gynecology and Obstetrics, University Clinical Centre in the Republic of Srpska. It covered 100 pregnant women with hypertension and 100 healthy pregnant women of gestation period from 28 to 40 weeks. Level of TBARS is determined as an equivalent of malondialdehyde standard, in accordance with recommendations by producer (Oxi Select TBARS Analisa Kit).Results:Pregnancy induced hypertension is a state of extremely increased oxidative stress. All pregnant women experiencing hypertension had increased TBARS values in medium value interval over 20 µmol, 66%, whereas in group of healthy pregnant women, only 1% experienced increased TBARS value. Pregnant women with difficult preeclampsia (32%) had high TBARS values, over 40 µmol, and with mild PIH, only 4.9% pregnant women.Conclusion:Pregnant women with pregnancy induced hypertension have extremely increased degree of oxidative stress and lipid peroxidation. TBARS values are in positive correlation with blood pressure values, respectively the highest TBARS value were present in pregnant women with the highest blood pressure values.

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“…MDA is a specific biomarker of lipid peroxidation. Higher oxidative stress during pregnancy increase blood MDA concentration [ 18 - 20 ]. Several defense mechanisms are available to prevent oxidative damage including scavenging systems as the enzymes glutathione peroxidase and SOD.…”

Section: Discussionmentioning

confidence: 99%

Impact of pregnancy and nutrition on oxidant⁄antioxidant balance in sheep and goats reared in South Sinai, Egypt

Nawito¹,

Hameed²,

Sosa³

et al. 2016

Vet World

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Aim:To monitor the effect of nutrition and pregnancy on oxidative status of animals under the arid condition of South Sinai.Materials and Methods:Blood samples were taken from two groups of animals: The first group retained in farm and fed on concentrate (high diet) and another group grazing natural forage (low diet). Each group was subdivided into pregnant and non-pregnant animals. Blood samples were assayed for their content of malondialdehyde (MDA), total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD) enzymes.Results:MDA level significantly increased in pregnant animals fed either concentrate or grazing low-quality forage and accompanied by a low level of TAC in pregnant grazing animals fed low-quality forage. The activity of CAT decreased in pregnant fed either concentrate or grazing and SOD significant decrease in the pregnant grazing group. These data suggested that the animals might have experienced some degree of oxidative stress and lipid peroxidation and indicating that redox homeostasis was impaired in those pregnant and specially fed on forage rations.Conclusion:Pregnancy constituted the most oxidative stress facing the grazing and concentrated diet feed sheep and goats under arid and saline conditions of Southern Sinai, Egypt.

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Comparative Study of Serum Malondialdehyde Levels as a Marker of Oxidative Stress in Patients of Pregnancy induced Hypertension and Controls

Cited by 13 publications

References 5 publications

Correlation of Oxidative Stress Markers with Ultrasound and Cardiotocography Parameters with Hypertension Induced Pregnancy

Correlation of Oxidative Stress Markers with Ultrasound and Cardiotocography Parameters with Hypertension Induced Pregnancy

Oxidative Stress Marker and Pregnancy Induced Hypertension

Impact of pregnancy and nutrition on oxidant⁄antioxidant balance in sheep and goats reared in South Sinai, Egypt

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