Comparative study of pathological lesions of liver in autopsy cases

Abstract

Background: Liver is a site for plethora of diseases among which many become symptomatic while others usually either go undiagnosed or are concealed by other prominent diseases. As said about liver to be the custodian of milieu interior most of the silent liver diseases are diagnosed only on autopsy examination. Aims and objectives was to study various pathological lesions of liver in medicolegal and clinical autopsy cases and to corelate liver diseases with age and sex. Retrospective cross-sectional observational study of 649 medicolegal and clinical autopsies conducted within 2 years of duration (January 2017 to December 2018).Methods: Out of all 649 autopsies conducted in our hospital all liver specimens along with other organs viscera were collected and formalin fixed. After gross examination sections from the liver were submitted for tissue processing and then stained with haematoxylin and eosin stain.Results: The most common pathology found in our study was fatty change (11.1%) followed by venous congestion (4.3%), hepatitis (3.5%), cirrhosis (2.2%), tuberculosis/ granulomatous hepatitis (0.6%), chronic hepatitis (0.3%), malignancy (1%), miscellaneous (2%) and normal (72.4%). Maximum cases were in 21-30 years of age group with male preponderance.Conclusions: Autopsy examination of liver is an effective tool to identify silent liver diseases. Use of autopsy findings along with other investigative techniques.

A Pathologist’s Perspective on Histopathology Examination of Autopsies and Various Incidental Findings

“…In the hepatic system, the m.c diagnosis was fatty liver followed by venous congestion and cirrhosis. These findings were similar to studies published by Algarsamy et al, Singal et al and Simon et al [18,19,20] The m.c finding in lung was CVS lung, followed by pneumonia, pulmonary edema, pulmonary TB and lung abscess. This is in agreement to study published by Kaur et al but in contrast to studies published by Arunlatha et al and Patel et al, showing pulmonary oedema as the m.c finding followed by CVS lung.…”