Study of Histomorphological Pattern of Liver Diseases in Autopsy Cases: A Retrospective Study at a Tertiary Care Hospital

Abstract

Introduction: Liver is affected by a variety of diseases, primary as well as secondary. The majority of chronic liver diseases may remain undiagnosed as some lesions have no clinical signs and symptoms. They are found incidentally during general health check-ups or at autopsy. Aims &Objective:- To study the histomorphological spectrum of liver lesions at autopsy irrespective of the cause of death., To assess the frequency of the different types of lesions. The present study was conducted on 400 liver autopsy Material And Methods: specimens received in the department of Pathology, Medical College, Baroda, Gujarat. Tissue sections from representative areas were processed, stained, and examined under the light microscope. Out of 400 specimens, 36 (9%) cases were autolyzed, 164(41%)cases showed conge Result: stion, followed by 110 (27.5%) cases of hepatic steatosis. Normal histology was found in 40(10%) cases, 20(5%) cases showed cirrhosis. Other ndings included periportal inammation in 10 (2.5%)cases, tuberculous granuloma in 5(1.25%)cases, metastatic tumor in 5(1.25%)cases, and 3(0.75%) cases showed the presence of sickle-shaped RBCs in blood vessels of the liver. Males predominated the study with a Male: Female ratio of 3.16:1. Maximum cases was in the age group of 31-40 years. Autopsy examination of liver is a valuable tool to identify silent Conclusion: liver diseases. In the present study, liver pathology is more common in males, the most common age group is 31-40 years, congestion and steatosis comprise signicant ndings