Comparative study of hydroxyapatite and octacalcium phosphate coatings deposited on metallic implants by PLD method

Mróz, W.; Bombalska, Aneta; Budner, Bogusław; Burdyńska, S.; Jedyński, M.; Prokopiuk, A.; Menaszek, E.; Ścisłowska-Czarnecka, Anna; Niedzielska, A.; Niedzielski, Kryspin

doi:10.1007/s00339-010-5926-3

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…The high resolution AFM topography imaging of the samples (Fig. 3 a, c, e noted that a similar structure of the coatings was previously noted in [42,43]. This is consistent with current physical models of PLD, as during the nanosecond laser ablation the gas plasma cloud is composed of ions and large clusters, which can be further integrated due to intense collisions during the motion of the plasma cloud from the target to the substrate [32], [44].…”

Section: Resultssupporting

confidence: 87%

The formation of calcium phosphate coatings by pulse laser deposition on the surface of polymeric ferroelectric

Bolbasov

Лапин

Svetlichnyi

et al. 2015

Applied Surface Science

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This work analyses the properties of calcium phosphate coatings obtained by pulsed laser deposition on the surface of the ferroelectric polymer material. Atomic force and scanning electron microscopy studies demonstrate that, regardless of the type of sputtering target, the calcium phosphate coatings have a multiscale rough surface that is potentially capable of promoting the attachment and proliferation of osteoblasts. This developed surface of the coatings is due to its formation mainly from a liquid phase. The chemical and crystalline 2 composition of the coatings depends on the type of sputtering target used. It was shown that, regardless of the type of sputtering target, the crystalline structure of the ferroelectric polymer material does not change. Cell viability and adhesion studies of mesenchymal stromal cells on the coatings were conducted using flow cytometry and fluorescent microscopy. These studies indicated that the produced coatings are non-toxic.

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Section: Resultssupporting

confidence: 87%

The formation of calcium phosphate coatings by pulse laser deposition on the surface of polymeric ferroelectric

Bolbasov

Лапин

Svetlichnyi

et al. 2015

Applied Surface Science

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“…This is in accordance with previous studies showing a more pronounced osteoblast attachment to an HA surface as compared to an OCP surface. Besides the difference in chemical composition and degradation properties, these two materials exhibited different grain size, which could also be of influence on cell attachment [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Monolithic calcium phosphate/poly(lactic acid) composite versus calcium phosphate-coated poly(lactic acid) for support of osteogenic differentiation of human mesenchymal stromal cells

Birgani

Blitterswijk

Habibović

2016

J Mater Sci: Mater Med

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Calcium phosphates (CaPs), extensively used synthetic bone graft substitutes, are often combined with other materials with the aim to overcome issues related to poor mechanical properties of most CaP ceramics. Thin ceramic coatings on metallic implants and polymer-ceramic composites are examples of such hybrid materials. Both the properties of the CaP used and the method of incorporation into a hybrid structure are determinant for the bioactivity of the final construct. In the present study, a monolithic composite comprising nano-sized CaP and poly(lactic acid) (PLA) and a CaP-coated PLA were comparatively investigated for their ability to support proliferation and osteogenic differentiation of bone marrow-derived human mesenchymal stromal cells (hMSCs). Both, the PLA/CaP composite, produced using physical mixing and extrusion and CaP-coated PLA, resulting from a biomimetic coating process at near-physiological conditions, supported proliferation of hMSCs with highest rates at PLA/CaP composite. Enzymatic alkaline phosphatase activity as well as the mRNA expression of bone morphogenetic protein-2, osteopontin and osteocalcin were higher on the composite and coated polymer as compared to the PLA control, while no significant differences were observed between the two methods of combining CaP and PLA. The results of this study confirmed the importance of CaP in osteogenic differentiation while the exact properties and the method of incorporation into the hybrid material played a less prominent role.

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“…The favorable effect of gelatin for producing the least soluble phases (HAP and OCP) in trial SBF-5 may be partially explained by the relatively higher viscosity induced in the mixing solutions, which under no stirring significantly affected the kinetics of the nucleation of HAP [1, 67,75]. As brushite and OCP are intermediate phases [33,86,87], a role for gelatin in this ionic reaction could be diffusion-controlling, favoring the time-demanding precipitation of the end product. On the other hand, in the trials with disodium phosphate (DSP), almost pure brushite was the product under stirring (trial SBF-1), while HAP with a minor amount of brushite was formed with no stirring (trial SBF-2).…”

Section: Sbf-based Wet Synthesis Of Hapmentioning

confidence: 99%

Optimizing the biomimetic synthesis of hydroxyapatite for the consolidation of bone using diammonium phosphate, simulated body fluid, and gelatin

et al. 2020

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Strategies involving the synthesis of hydroxyapatite (HAP) are significant in health and materials sciences, and lately, in heritage science. Conditions for the optimized heterogeneous formation of HAP for consolidating bone are investigated using a simple methodology with discs of calcium-containing starting materials and phosphate-containing reagent solutions; the results were evaluated against whole bone specimens. Diammonium phosphate (DAP) solutions with simulated body fluid (SBF) and gelatin as cofactors in all combinations were used in trials, while the products were characterized by microscopy, elemental microanalysis, X-Ray diffractometry, and Fourier transform infrared spectroscopy. The hypothesis that bone, SBF, and gelatin may biomimetically promote HAP formation was tested through a simple experimental design. The results showed that HAP is generally formed in mixtures with octacalcium phosphate (OCP), as well as calcium hydrogen phosphate dihydrate (brushite). The precipitation of carbonate HAP signals the formation of a biocompatible product in the cases where SBF and gelatin were employed as cofactors. Gelatin was found to further promote the product formation in most cases. It was shown that DAP, as well as its combination with gelatin, could predominantly form HAP in most trials, while OCP is co-crystallized in SBF-containing solutions.

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Comparative study of hydroxyapatite and octacalcium phosphate coatings deposited on metallic implants by PLD method

Cited by 12 publications

References 20 publications

The formation of calcium phosphate coatings by pulse laser deposition on the surface of polymeric ferroelectric

The formation of calcium phosphate coatings by pulse laser deposition on the surface of polymeric ferroelectric

Monolithic calcium phosphate/poly(lactic acid) composite versus calcium phosphate-coated poly(lactic acid) for support of osteogenic differentiation of human mesenchymal stromal cells

Optimizing the biomimetic synthesis of hydroxyapatite for the consolidation of bone using diammonium phosphate, simulated body fluid, and gelatin

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