Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma

Tateishi, Ukihide; Hosono, Ako; Makimoto, Atsushi; Nakamoto, Yuji; Kaneta, Tomohiro; Fukuda, Hiroshi; Murakami, Koji; Terauchi, Takashi; Suga, Tetsuya; Inoue, Tomio; Kim, Edmund E.

doi:10.1007/s12149-008-0219-z

Cited by 102 publications

(60 citation statements)

References 12 publications

(16 reference statements)

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“…Initial results of PET and PET/CT in the diagnosis and risk stratification of patients with rhabdomyosarcoma are promising. PET can be used to assess the primary tumor and to improve staging (18,19,20). Results in other sarcomas such as osteosarcoma, chondrosarcoma, and Ewing tumors indicate that PET/CT is predictive of outcome (14,15,17,21).…”

Section: Discussionmentioning

confidence: 99%

Contribution of PET/CT to Prediction of Outcome in Children and Young Adults with Rhabdomyosarcoma

Baum

Frühwald²,

Rahbar³

et al. 2011

J Nucl Med

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The purpose of this retrospective study was to evaluate the role of 18 F-FDG PET or PET/CT in the prediction of patient outcome in children and young adults affected by rhabdomyosarcoma. Methods: Forty-one patients with histology-proven rhabdomyosarcoma who underwent PET or PET/CT were identified (age range, 1-20 y; mean age 6 SD, 9.9 6 5.8 y). Tumor maximum standardized uptake value (SUV max ) and visually rated metabolic activity, as well as the presence of metabolically active lymph nodes and distant metastases, were compared with event-free and overall survival. Multivariate Cox regression analyses were performed to compare the prediction of outcome according to metabolic tumor intensity in relation to established prognostic factors. Results: Kaplan-Meier analyses revealed a significantly shorter overall survival in primary tumors visually rated as highly metabolically active or with a ratio of SUV max to SUV of the liver above 4.6. In addition, metabolically active lymph node and distant site involvement was indicative of significantly lower survival rates. On multivariate Cox regression analysis, the impact of intensity or SUV max of the primary tumor on outcome failed to attain significance, although PET performed better than some of the prognostic factors established in larger patient groups (P 5 0.081). Conclusion: 18 F-FDG PET/ CT is a valuable tool for initial staging in children affected by rhabdomyosarcoma. 18 F-FDG PET/CT may be an additional predictor of outcome and may be used to refine risk-adapted therapy. PET performed better than some established risk factors. The borderline significance level of primary tumor metabolism in multivariate testing may be an effect of the limited sample size. Further prospective evaluations are warranted.

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Section: Discussionmentioning

confidence: 99%

Contribution of PET/CT to Prediction of Outcome in Children and Young Adults with Rhabdomyosarcoma

Baum

Frühwald²,

Rahbar³

et al. 2011

J Nucl Med

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“…12 As regard the detection of primary sites of RMS, literature data report 100% sensitivity and specificity for each imaging modality at initial staging. 13,14 Furthermore, SUV max 15 at the primary site seems to be correlated with tumor grade 16,17 and with prognosis, 18 given the significant association between high initial SUV max and increased risk of death. Mean SUV max of 12 primary RMS prospectively assessed by Völker et al was 7.0 Ϯ 3.4.…”

Section: Discussionmentioning

confidence: 99%

Additional Benefit of F-18 FDG PET/CT in the Staging and Follow-up of Pediatric Rhabdomyosarcoma

Ricard¹,

Cimarelli²,

Deshayes³

et al. 2011

Clinical Nuclear Medicine

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“…La TEP-scanographie au FDG (fluorodé-soxyglucose) est utilisée dans le bilan d'extension des sarcomes de l'adulte, mais son utilisation est très limitée dans la population pédiatrique [2]. Quelques publications pédiatriques ont rapporté une meilleure appréciation de l'extension locorégionale ganglionnaire et la détection des métastases occultes avec la TEPscanographie [9][10][11].…”

Section: Discussionunclassified

Rhabdomyosarcome embryonnaire paratesticulaire : à propos d’un cas et revue de la littérature

Ghorbal

Abid

Elloumi

et al. 2015

Cancer/Radiothérapie

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Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma

Abstract: FDG PET/CT is more accurate than CI regarding clinical staging and re-staging of patients with rhabdomyosarcomas.

Cited by 102 publications

References 12 publications

Contribution of PET/CT to Prediction of Outcome in Children and Young Adults with Rhabdomyosarcoma

Contribution of PET/CT to Prediction of Outcome in Children and Young Adults with Rhabdomyosarcoma

Additional Benefit of F-18 FDG PET/CT in the Staging and Follow-up of Pediatric Rhabdomyosarcoma

Rhabdomyosarcome embryonnaire paratesticulaire : à propos d’un cas et revue de la littérature

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