Comparative Study of Cefixime and Tetracycline: Measuring Effectiveness of Strategies to Improve Appropriate Antibiotic Use in the Treatment of Acute Respiratory Tract Infections (ARTIs) in Urban Population Indonesia.

Abstract

Objective. Antibiotic resistance is a serious threat that occurs globally in the health sector due to increased consumption of inappropriate antibiotics. Guidelines for prescribing antibiotics for ARTIs have been issued in general practice to promote rational antibiotic prescribing. This study was conducted to compare the effectiveness of cefixime and tetracycline as a solution to improve monitoring of appropriate antibiotic use in the treatment of ARTIs.Methods. All stock isolates were rejuvenated first, and cultured on standard media and Kirby-Bauer disc diffusion method was used for susceptibility testing in accordance with the Clinical and Laboratory Standard Institute's (CLSI) recommendations. Identification of bacteria from a single isolate was carried out to determine which bacteria were resistant to cefixime and tetracycline.Results. A total of 466 single isolates of bacteria were analyzed, which showed a percentage of resistance to cefixime 38.0 %, and tetracycline 92.86 %. Bacterial isolates were resistant to cefixime and tetracycilne was a genus of Haemophilus, Streptococcus, Corynebacterium, Staphylococcus, and bordetella. Conclusions. Cefixime compared to tetracycline was proven to be superior in terms of the effectiveness of ARIs treatment.