Comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide

El-Kosasy, Amira M.; Nebsen, Marianne; El-Rahman, Mohamed K. Abd; Salem, Maissa Y.; El-Bardicy, M. G.

doi:10.1016/j.talanta.2011.04.071

Cited by 41 publications

(27 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A more recent comparative study revealed the superiority of calixarenes over cyclodextrins as molecular receptors for these structurally similar anticholinesterase drugs [9]. With the purpose of achieving more selective binding to PB, the ionophore calix [6]arene (CX6) was chosen because it is more membrane-compatible and possesses outstanding complexation properties toward quaternary ammonium ions [10].…”

Section: Ise Characteristics Using Cx6 As a Sensing Ionophorementioning

confidence: 99%

Ion selective electrode (in-line analyzer) versus UV-spectroscopy (at-line analyzer); which strategy offers more opportunities for real time monitoring of the degradation kinetics of pyridostigmine bromide

El-Rahman

Salem

2015

Sensors and Actuators B: Chemical

Self Cite

View full text Add to dashboard Cite

Section: Ise Characteristics Using Cx6 As a Sensing Ionophorementioning

confidence: 99%

Ion selective electrode (in-line analyzer) versus UV-spectroscopy (at-line analyzer); which strategy offers more opportunities for real time monitoring of the degradation kinetics of pyridostigmine bromide

El-Rahman

Salem

2015

Sensors and Actuators B: Chemical

Self Cite

View full text Add to dashboard Cite

“…Stability indicating electrochemical ion-selective electrodes (18) along with application on plasma samples (19) followed. The introduction of ionophores enhanced selectivity and improved electrode response toward electroactive analytes (20). More recently, monitoring kinetic study of the degradation process of electroactive drugs was carried out using membrane electrodes either off- (21) or online (22) during hydrolytic degradation.…”

Section: Resultsmentioning

confidence: 99%

Stability Study and Kinetic Monitoring of Cefquinome Sulfate Using Cyclodextrin-Based Ion-Selective Electrode: Application to Biological Samples

Yehia

Arafa

Abbas

et al. 2016

Journal of AOAC INTERNATIONAL

View full text Add to dashboard Cite

Two novel cefquinome sulfate (CFQ)-selective electrodes were performed with dibutyl sebacate as a plasticizer using a polymeric matrix of polyvinyl chloride. Sensor 1 was prepared using sodium tetraphenylborate as a cation exchanger without incorporation of ionophore, whereas 2-hydroxy propyl β-cyclodextrin was used as ionophore in sensor 2. A stable, reliable, and linear response was obtained in concentration ranges 3.2 × 10(-5) to 1 × 10(-2) mol/L and 1 × 10(-5) to 1 × 10(-2) mol/L for sensors 1 and 2, respectively. Both sensors could be sufficiently applied for quantitative determination of CFQ in the presence of degradation products either in bulk powder or in pharmaceutical formulations. Sensor 2 provided better selectivity and sensitivity, wider linearity range, and higher performance. Therefore it was used successfully for accurate determination of CFQ in biological fluids such as spiked plasma and milk samples. Furthermore, an online kinetic study was applied to the CFQ alkaline degradation process to estimate the reaction rate and half-life with feasible real-time monitoring. The developed sensors were found to be fast, accurate, sensitive, and precise compared with the manufacturer's reversed-phase chromatographic method.

show abstract

“…Research in the field of development of potentiometric sensors is gaining more and more attention and a number of potentiometric sensors have been developed for the determination of species in the areas of chemical, pharmaceutical and biomedical analyses [30][31][32][33][34][35][36][37][38][39][40][41] . Potentiometric sensors have extensive applications to quantify the compounds since they neither require sophisticated instrument nor relying on stringent experimental conditions.…”

Section: Fig 1 Chemical Structure Of Lmtmentioning

confidence: 99%

Novel membrane sensor for determination of lamotrigine in pharmaceuticals and urine

Rajendraprasad¹

2019

10.5267/j.ccl

View full text Add to dashboard Cite

Lamotrigine (LMT), chemically known as [6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5diamine], is a broad spectrum antiepileptic drug, used as monotherapy and as an adjunct with other antiepileptic drugs for treatment of partial and generalized toxic-clonic seizures. It is used to treat neurological lesions and as a tranquilizer. A selective electrochemical membrane sensor has been developed and validated for determination of LMT. The membrane constructed using LMT and molybdophosphoric acid in THF and PVC is applicable for the detection of 5 × 10-4 to 9 × 10-3 M LMT in the pH range between 4.6 and 5.8 with the Nernstian slope of 57.14±1 mV/decade. The regression coefficient value of 0.9932 showed a good linear correlation between the concentrations of LMT and measured cell potentials. The limits of detection (LOD) and quantification (LOQ) values for the fabricated sensor were 1.3 × 10-5 and 4 × 10-5 M LMT, respectively. Various experimental conditions were optimized to reach the effective performance characteristics of the sensor. The effect of various cations, anions and organic species on the performance of sensor was studied by following standard-addition procedure. The results revealed no such variations due to presence of foreign ions or species. The fabricated sensor was subjected to validation to check accuracy, precision, robustness and ruggedness. The mean accuracy for determination of LMT was found to be 99.16%. The developed sensor was successfully used to determine LMT in tablets and in spiked human urine.

show abstract

Comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide

Cited by 41 publications

References 31 publications

Ion selective electrode (in-line analyzer) versus UV-spectroscopy (at-line analyzer); which strategy offers more opportunities for real time monitoring of the degradation kinetics of pyridostigmine bromide

Ion selective electrode (in-line analyzer) versus UV-spectroscopy (at-line analyzer); which strategy offers more opportunities for real time monitoring of the degradation kinetics of pyridostigmine bromide

Stability Study and Kinetic Monitoring of Cefquinome Sulfate Using Cyclodextrin-Based Ion-Selective Electrode: Application to Biological Samples

Novel membrane sensor for determination of lamotrigine in pharmaceuticals and urine

Contact Info

Product

Resources

About