Stability Study and Kinetic Monitoring of Cefquinome Sulfate Using Cyclodextrin-Based Ion-Selective Electrode: Application to Biological Samples

Abstract

Two novel cefquinome sulfate (CFQ)-selective electrodes were performed with dibutyl sebacate as a plasticizer using a polymeric matrix of polyvinyl chloride. Sensor 1 was prepared using sodium tetraphenylborate as a cation exchanger without incorporation of ionophore, whereas 2-hydroxy propyl β-cyclodextrin was used as ionophore in sensor 2. A stable, reliable, and linear response was obtained in concentration ranges 3.2 × 10(-5) to 1 × 10(-2) mol/L and 1 × 10(-5) to 1 × 10(-2) mol/L for sensors 1 and 2, respectively. Both sensors could be sufficiently applied for quantitative determination of CFQ in the presence of degradation products either in bulk powder or in pharmaceutical formulations. Sensor 2 provided better selectivity and sensitivity, wider linearity range, and higher performance. Therefore it was used successfully for accurate determination of CFQ in biological fluids such as spiked plasma and milk samples. Furthermore, an online kinetic study was applied to the CFQ alkaline degradation process to estimate the reaction rate and half-life with feasible real-time monitoring. The developed sensors were found to be fast, accurate, sensitive, and precise compared with the manufacturer's reversed-phase chromatographic method.

Input of Electroanalytical Methods for the Determination of Diclofenac: A Review of Recent Trends and Developments

“…(MNPÀ Fe 3 O 4 ) sensors were also constructed using cation exchangers such as malachite green (MG) and crystal violet (CV) with β-Cyclodextrins (β-CD) forming the respective (MGÀ Fe (β-CD)) and (CVÀ Fe (β-CD)). [50,97] These ISEs lead to rapid and sensitive detection of DCL in wastewater samples and pharma- ceutical dosage form in the presence of anionic and organic interfering substances. Conductive polymers were also used for the preparation of the ISE membranes.…”

Characteristics, Properties and Analytical Methods of Cefquinome - A Review

“…Stability study and kinetic monitoring of cefquinome sulfate using cyclodextrin-based ion-selective electrode were developed by Yehia AM, et al, 38 . Shantier SW et al and Dołhań A et al, 39,40 developed chromatographic and spectrophotometric methods for the analysis and stability studies of cefquinome sulphate in bulk and pharmaceutical dosage forms.…”

A Reliable Electrochemical Sensor Based on Functionalized Magnetite Nanoparticles for Over‐the‐counter Allergy Medication Abuse Sensing in Biological Fluids

“…A standard addition technique [35] was employed to eliminate the possibility of potential measurements deviation resulting from matrix interference. This was performed by successive small additions of DIPH standard solution (1.0 × 10 À 4 M) into accurate aliquots of diluted spiked milk and human plasma.…”

“…Herein, the optimized sensor IV was successfully employed for selective sensing of DIPH in spiked human plasma and milk samples utilizing the standard addition approach [35], where the effects of the samples matrix are solved. The following equation was used for plotting a linear relationship between (V 0 + V std ) 10 E2-E1/S and C std.…”