Comparative studies on the implantation of nano platinum black and pure platinum electrodes in the rabbit orbicularis oculi muscle

Zhang, Y; Li, K Y; Cheng, Jinghui; Wang, Y T; Geng, Lihua; Sun, Yajing; Tian, Hong-Chang; Liu, J Q; Jin, Xuefeng

doi:10.1017/s0022215114001558

Cited by 5 publications

(4 citation statements)

References 20 publications

(39 reference statements)

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“…However, to follow the DC strategy faithfully, EMG signals should also be obtained from the antagonist levator palpebrae muscle. To our knowledge, previous reports on electrode implantation into the eyelid are limited to the orbicularis oculi muscle in rabbits [ 16 ] and dogs [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

A blinking periorbital prosthesis using surface electromyographic signals of the orbicularis oculi muscle

Akamatsu

Kawashima

Tsunekuni³

et al. 2015

Eur J Plast Surg

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BackgroundRecent advances in human–machine interface technology have enabled the development of multifunctional, primarily orthopedic myoelectric prostheses. We developed a noninvasive blinking periorbital prosthesis that can synchronize with blinking of the intact eyelid by using surface electromyographic signals of the orbicularis oculi muscle.MethodsMyoelectric potentials of the orbicularis oculi muscle while blinking were measured with surface electrodes on the eyelid in four healthy adults. Possible cross talk introduced via the electrodes was also measured and assessed to determine whether cross talk would affect surface electromyographic measurements while blinking.ResultsThe amplitude of the surface myoelectric potential of the orbicularis oculi muscle was sufficiently high for the practical use of blinking prostheses. Our blinking model was successfully synchronized with blinks of the subjects’ eyelids under experimental conditions without cross talk between the orbicularis oculi muscle and other muscles.ConclusionsAlthough our study revealed several problems, the use of surface electromyographic signals could be a promising and useful technique for synchronizing blinking of the prosthetic eyelid with blinking of the intact eyelid.Level of Evidence: Level V, therapeutic study.Electronic supplementary materialThe online version of this article (doi:10.1007/s00238-015-1111-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A blinking periorbital prosthesis using surface electromyographic signals of the orbicularis oculi muscle

Akamatsu

Kawashima

Tsunekuni³

et al. 2015

Eur J Plast Surg

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“…The stimulating module included a three-channel stimulation electrode and one reference electrode. These electrodes were made of nano platinum black, which was demonstrated to be safe and effective in previous research ( 6 ). In the current research the processing chip was implanted into the forehead of the facial nerve paralyzed animal model.…”

Section: Methodsmentioning

confidence: 99%

Restoration of orbicularis oculi muscle function in rabbits with peripheral facial paralysis via an implantable artificial facial nerve system

Sun

Cheng

et al. 2017

Exp Ther Med

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The purpose of the present study was to restore orbicularis oculi muscle function using the implantable artificial facial nerve system (IAFNS). The in vivo part of the IAFNS was implanted into 12 rabbits that were facially paralyzed on the right side of the face to restore the function of the orbicularis oculi muscle, which was indicated by closure of the paralyzed eye when the contralateral side was closed. Wireless communication links were established between the in vivo part (the processing chip and microelectrode) and the external part (System Controller program) of the system, which were used to set the working parameters and indicate the working state of the processing chip and microelectrode implanted in the body. A disturbance field strength test of the IAFNS processing chip was performed in a magnetic field dark room to test its electromagnetic radiation safety. Test distances investigated were 0, 1, 3 and 10 m, and levels of radiation intensity were evaluated in the horizontal and vertical planes. Anti-interference experiments were performed to test the stability of the processing chip under the interference of electromagnetic radiation. The fully implanted IAFNS was run for 5 h per day for 30 consecutive days to evaluate the accuracy and precision as well as the long-term stability and effectiveness of wireless communication. The stimulus intensity (range, 0–8 mA) was set every 3 days to confirm the minimum stimulation intensity which could indicate the movement of the paralyzed side was set. Effective stimulation rate was also tested by comparing the number of eye-close movements on both sides. The results of the present study indicated that the IAFNS could rebuild the reflex arc, inducing the experimental rabbits to close the eye of the paralyzed side. The System Controller program was able to reflect the in vivo part of the artificial facial nerve system in real-time and adjust the working pattern, stimulation intensity and frequency, range of wave and stimulation time. No significant differences in the stimulus intensities were observed during 30 days. The artificial facial nerve system chip operation stable in the anti-interference test, and the radiation field strength of the system was in a safe range according to the national standard. The IAFNS functioned without any interference and was able to restore functionality to facially paralyzed rabbits over the course of 30 days.

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“…The demonstration of MEA fabrication on hydrogel substrates is an important step toward neural implants which match the mechanical properties of the brain and other excitable tissue. Similar to silver, platinum has been briefly explored for use in neural interfaces, [88][89][90] but nano-platinum must be carefully employed due to its potential as a highly reactive catalyst of simple compounds that may be found in physiological media. [91][92] Shah et al used nano-cluster platinum films to enhance implantable electrode performance.…”

Section: Metal and Alloy Nano-coatingsmentioning

confidence: 99%

Neuro‐Nano Interfaces: Utilizing Nano‐Coatings and Nanoparticles to Enable Next‐Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation

Young

Cornwell

Daniele

2017

Adv Funct Materials

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to record or modulate electrical activity of the nervous system. Although these electrode systems are both mechanically and operationally robust, they have limited utility due to the resultant macroscale damage from invasive implantation. For this reason, novel nanomaterials are being investigated to enable new strategies to chronically interact with the nervous system at both the cellular and network level. In this feature article, the use of nanomaterials to improve current electrophysiological interfaces, as well as enable new nano-interfaces to modulate neural activity via alternative mechanisms, such as remote transduction of electromagnetic fields are explored. Specifically, this article will review the current use of nanoparticle coatings to enhance electrode function, then an analysis of the cuttingedge, targeted nanoparticle technologies being utilized to interface with both the electrophysiological and biochemical behavior of the nervous system will be provided. Furthermore, an emerging, specialized-use case for neural interfaces will be presented: the modulation of the blood-brain barrier.

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Comparative studies on the implantation of nano platinum black and pure platinum electrodes in the rabbit orbicularis oculi muscle

Cited by 5 publications

References 20 publications

A blinking periorbital prosthesis using surface electromyographic signals of the orbicularis oculi muscle

A blinking periorbital prosthesis using surface electromyographic signals of the orbicularis oculi muscle

Restoration of orbicularis oculi muscle function in rabbits with peripheral facial paralysis via an implantable artificial facial nerve system

Neuro‐Nano Interfaces: Utilizing Nano‐Coatings and Nanoparticles to Enable Next‐Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation

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