Comparative Studies of Pigpox and Vaccinia Viruses

Datt, N. S.

doi:10.1016/s0368-1742(64)80007-2

Cited by 19 publications

(4 citation statements)

References 8 publications

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“…A 20 % suspension of infected CAM was made in 0-004M Mcllvaine buffer and was treated with 'Genetron 226' (CF2Cl, CFC12) on the lines described by Datt (1964) with slight modifications.…”

Section: Preparation Of Virus Suspensionmentioning

confidence: 99%

Studies on the serological relationships between avian pox, sheep pox, goat pox and vaccinia viruses

Uppal

Nilakantan

1970

J. Hyg.

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SUMMARYBy using neutralization, complement fixation and immunogel-diffusion tests, it has been demonstrated that cross-reactions occur between various avian pox viruses and between sheep pox and goat pox viruses. No such reactions were demonstrated between avian pox viruses and vaccinia virus or between avian pox and sheep pox and goat pox viruses. Furthermore, no serological relationship was demonstrable between vaccinia virus and sheep pox and goat pox viruses.

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“…A 20 % suspension of infected CAM was made in 0-004M Mcllvaine buffer and was treated with 'Genetron 226' (CF2Cl, CFC12) on the lines described by Datt (1964) with slight modifications.…”

Section: Preparation Of Virus Suspensionmentioning

confidence: 99%

Studies on the serological relationships between avian pox, sheep pox, goat pox and vaccinia viruses

Uppal

Nilakantan

1970

J. Hyg.

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“…In epidermal cells of pigs inoculated with vaceinia virus, DATT (6) found small granular cytoplasmic inclusions, whereas Lgr]3KE (13) did not find any cytoplasmic inclusions. According to DowNIE (7), in case of vaceinia virus infection in chicken embryos, guinea-pigs and rabbits, acidophilie granular inclusions were sometimes found as a single mass at one side in the cell but they were frequently distributed throughout the cytoplasm.…”

Section: Introductionmentioning

confidence: 97%

Cytoplasmic and nuclear inclusions in epidermal cells of pigs inoculated with vaccinia viruses

Moriguchi

1977

Archives of Virology

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The morphology of cytoplasmic and nuclear inclusions in the epidermal cells of pigs inoculated with vaccinia viruses was studied. Cytoplasmic inclusions observed were those corresponding to type B described by KAMAHORA et al. (11). They were subdivided into three morphologic types and were tentatively designated type B-1, B-2 and B-3, respectively. Type B-1 was eosinophilic, granular in structure, relatively large in size, and round or ovoid in shape. Type B-2 was poorly stained with hematoxylin and eosin, granular in structure, small in size, and was a relatively elongated mass along the nuclear membrane. Type B-3 was basophilic, and was a uniformly stained small body. Electron microscopically, various aberrant findings were seen in most of the cytoplasmic inclusions and they differed depending on their types. Nuclear inclusions could also be classified microscopically into three morphologic types. Type 1 was eosinophilic or neutrophilic and had a homogeneous structure. Type 2 was eosinophilic and fibrillar in structure. Type 3 appeared as small eosinophilic bodies. Electron microscopically type 1 was found to be composed of fine fibro-granular structures, type 2 was found to be composed of relatively long filaments which resembled tonofilaments, and type 3 consisted of unique fibrillar structures.

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“…Clinical studies, experimental infection of laboratory animals and in vitro infection of cell lines originating from different species have shown that SWPV displays a high degree of host specificity with infections restricted to domestic pigs [17] with a single case reported in a wild boar [18]. Experimental infection of other species with SWPV including rats, mice and rabbits have been unsuccessful with respect to induction of viremia or skin lesions pathognomonic of swinepox [19]. Similarly, infection of nonporcine mammalian or avian cell lines failed to produce viral particles [20].…”

Section: Introductionmentioning

confidence: 99%

Swinepox Virus Strains Isolated from Domestic Pigs and Wild Boar in Germany Display Altered Coding Capacity in the Terminal Genome Region Encoding for Species-Specific Genes

Kaiser

Wiedemann

Kühl³

et al. 2021

Viruses

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Swinepox virus (SWPV) is a globally distributed swine pathogen that causes sporadic cases of an acute poxvirus infection in domesticated pigs, characterized by the development of a pathognomonic proliferative dermatitis and secondary ulcerations. More severe disease with higher levels of morbidity and mortality is observed in congenitally SWPV-infected neonatal piglets. In this study, we investigated the evolutionary origins of SWPV strains isolated from domestic pigs and wild boar. Analysis of whole genome sequences of SWPV showed that at least two different virus strains are currently circulating in Germany. These were more closely related to a previously characterized North American SWPV strain than to a more recent Indian SWPV strain and showed a variation in the SWPV-specific genome region. A single nucleotide deletion in the wild boar (wb) SWPV strain leads to the fusion of the SPV019 and SPV020 open reading frames (ORFs) and encodes a new hypothetical 113 aa protein (SPVwb020-019). In addition, the domestic pig (dp) SWPV genome contained a novel ORF downstream of SPVdp020, which encodes a new hypothetical 71aa protein (SPVdp020a). In summary, we show that SWPV strains with altered coding capacity in the SWPV specific genome region are circulating in domestic pig and wild boar populations in Germany.

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Comparative Studies of Pigpox and Vaccinia Viruses

Cited by 19 publications

References 8 publications

Studies on the serological relationships between avian pox, sheep pox, goat pox and vaccinia viruses

Studies on the serological relationships between avian pox, sheep pox, goat pox and vaccinia viruses

Cytoplasmic and nuclear inclusions in epidermal cells of pigs inoculated with vaccinia viruses

Swinepox Virus Strains Isolated from Domestic Pigs and Wild Boar in Germany Display Altered Coding Capacity in the Terminal Genome Region Encoding for Species-Specific Genes

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