Comparative Studies of Lewis Acidity of Alkyl-Tin Chlorides in Multicomponent Biginelli Condensation Using Grindstone Chemistry Technique

Abstract

A simple and efficient procedure for the one pot Biginelli Condensation Reaction of aldehydes, β-ketoester and urea employing SnCl 4 .5H 2 O /mono/di/tributyl-tin chloride as a novel catalyst is described. Compared to classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity. Further, comparative efficiency of alkyl-tin chlorides in multicomponent Biginelli Condensation Reaction is also studied under solvent free conditions.

Multicomponent mechanochemical synthesis

“… 52 Alternatively, Singh and co-workers have proposed SnCl 4 ·5H 2 O as a Lewis acid catalyst for the “grindstone” Biginelli reaction. 53 …”

Environ-Economic Synthesis and Characterization of Some New 1,2,4-Triazole Derivatives as Organic Fluorescent Materials and Potent Fungicidal Agents

“…In continuation of our work to develop greener and expeditious protocols for the synthesis of heterocyclic compounds [44][45][46][47][48], herein we wish to report a highly efficient procedure for the synthesis of new substituted-2H-1,2,4-triazole phenol derivatives (4) and spiro (indole-triazole) propanoic acid derivatives (5) using water (containing 1-2 mL of alcohol) by the reaction of 4-chloro-2-nitro aniline (1)/amino acids (1 ) and aromatic aldehydes (2)/1H indole-2,3-diones (2 ), respectively, with thiosemicarbazide (3) yielding triazole (4)/spiro indole-triazole (5) derivatives in high yields and shorter reaction displaying excellent florescent property (Scheme 1).…”

Untitled

“…Solid-state reactions occur more efficiently and more selectively than does the solution reaction. 52 This method is superior to conventional method; since it is eco-friendly, high yielding requires no special apparatus, non-hazardous, operationally simple and convenient 53 . Here we used simple mortar and pastel for grinding purpose and microwave irradiation to complete the reaction.…”