Environ-Economic Synthesis and Characterization of Some New 1,2,4-Triazole Derivatives as Organic Fluorescent Materials and Potent Fungicidal Agents

Abstract

A multicomponent one-pot clean cyclocondensation reaction of 4-chloro-2-nitro aniline/amino acids and aromatic aldehydes/ indole-2,3-diones with thiosemicarbazide in water yielding triazole/spiro indole-triazole derivatives in high yields and shorter reaction time and displaying excellent florescent property is reported. The developed MCR may provide a valuable practical tool for the synthesis of new drugs containing the title core fragment. All the newly synthesized compounds have been characterized by IR, 1 HNMR, 13 CNMR, and fluorescence study and also been screened for antimicrobial activity.

Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

“…After the successful completion of reaction in water in the presence of POCl 3 , we decided to synthesize Schiff bases by employing lemon juice (2 mL) as green catalyst for green approach (Scheme 1) resulting in quantitative yield (70-86%) of the corresponding Schiff bases within 2 to 3 hrs. However, in the absence of lemon juice, spiro(indole-triazoles) are formed [43]. We have also carried out this reaction in the presence of citric acid but the yield of the product (4) was found to be low (60-70%) as compared to that carried out using lemon juice as a green catalyst (70-86%).…”

Alum Catalyzed Simple, Efficient, and Green Synthesis of 2‐[3‐Amino‐5‐methyl‐5‐(pyridin‐3‐yl)‐1,5‐dihydro‐4H‐1,2,4‐triazol‐4‐yl]propanoic Acid Derivatives in Aqueous Media

“…The condensation of 3-acetyl pyridine with various amino acids/cysteine amino acid yielded 2-{[1-(pyridin-3-yl)ethylidene]amino}propanoic acid (3) /ethyl 2-{[1-(pyridin-3-yl)ethylidene]amino}-3-sulfanylpropanoate (7) which “insitu” were cyclocondensed with thiosemicarbazide (4) in the presence of alum in aqueous medium to give exclusively 5a–i/9a , respectively, in 86–90% ( Scheme 1 ) ( Table 1 ). We have recently reported [ 33 ] the environ-economic synthesis of some new 1,2,4-triazole derivatives by the reaction of 4-chloro-2-nitro aniline and aromatic aldehydes with thiosemicarbazide in high yields and shorter reaction time in the presence of lemon juice as a green catalyst.…”

Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment

“…In order to complete these needs, chemical reactions are proceeds in solvent-free, water as a solvent, ionic liquids, bio-based chemicals and supercritical fluids as green solvents. The increasing interest to employ fruit juice in biocatalysts and in the synthesis of heterocyclic was achieved [31][32][33][34][35][36][37][38]. Recently, more attention has been attracted on targeting anticancer drugs disrupting tumor-specific cell signaling, cell division, energy metabolism, gene expression, drug resistance and so on.…”