Comparative Radiographic Evaluation of Alveolar Bone Healing Associated With Autologous Platelet-Rich Plasma After Impacted Mandibular Third Molar Surgery

Clinical Evaluation of Use of Platelet Rich Plasma in Bone Healing

“…In some cases it shows accelerated bone healing, in some cases no comparable bone healing and in some cases no changes in intervention and control group. Some results are compatible with earlier reports on PRP by Ronaldo Célio-Mariano et al [12] who observed earlier bone formation with the use of PRP. PRP alone was used as a graft material in few studies conducted to investigate the effect on bone formation.…”

“…Recently, much has been learned about the mechanisms involved in the regeneration and repair of some tissues. Thus, investigation of new methods of bone reconstruction of the maxillomandibular complex is always valid [12]. In 1998, Marx and Garg [8] proposed the local application of platelet-rich plasma (PRP) to enhance the maturation of bone grafts.…”

“…Its therapeutic strategy is based on acceleration of healing by concentrations of growth factors, which are universal initiators of nearly all healing events [3,5,12]. The growth factors present in PRP are well-known, including transforming growth factor-b (TGF-b1 and TGFb2), vascular endothelial growth factor, 3 isomers of platelet-derived growth factor (PDGF-aa, PDGF-bb, and PDGF-ab), and endothelial growth factor.…”

“…The growth factors present in PRP are well-known, including transforming growth factor-b (TGF-b1 and TGFb2), vascular endothelial growth factor, 3 isomers of platelet-derived growth factor (PDGF-aa, PDGF-bb, and PDGF-ab), and endothelial growth factor. These growth factors are considered to have the ability to accelerate chemotaxis, mitogenesis, angiogenesis, and synthesis of collagen matrix and favor tissue repair when applied on bone wounds [12]. Instead of this it has been noted that in addition to growth factors released from platelets and their demonstrated positive effect on wound healing, thrombospondin TSP is also abundant in the a-granules of platelets.…”

“…Some investigators have reported significant improvements in tissue healing and bone formation using PRP [1,4,7,8,11,12,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] whereas others did not observe improvements [2,5,13,14,[32][33][34][35][36]. Some have given no conclusion regarding effect of PRP application in maxillofacial region than periodontal defects [37].…”