Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial

Anitua, Eduardo; Murias-Freijo, Alia; Alkhraisat, Mohammad Hamdan; Orive, Gorka

doi:10.1007/s00784-014-1278-2

Cited by 72 publications

(99 citation statements)

References 29 publications

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“…Improvement in pain perception and quality of life has been reported in several randomized clinical trials, e.g. for pain associated with knee osteoarthritis [27,28,29], postoperative pain associated with molar tooth extractions [30], and for some oral surgery procedures such as the elevation of the maxillary sinus [31]. Moreover, this ‘analgesic' effect in EDE patients could be related to NF-κB pathway-mediated anti-inflammatory effects of PRGF [22,32].…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Autologous Plasma Rich in Growth Factors Eye Drops for the Treatment of Evaporative Dry Eye

Merayo‐Lloves

Sánchez-Ávila²,

Riestra³

et al. 2016

Ophthalmic Res

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Purpose: To provide preliminary information about the safety and efficacy of plasma rich in growth factors (PRGF) in the treatment of evaporative dry eye (EDE) and analyze the influence of certain variables on treatment outcomes. Methods: This retrospective study included patients with EDE treated between January 2011 and December 2013. Outcome measures including signs and symptoms of the disease were evaluated before and after treatment. The influence of some of the patient's clinical variables on results was assessed. Safety assessment was also performed. Results: Eighty-three patients with a total of 156 eyes were evaluated. Statistically significant reductions in the Ocular Surface Disease Index (38.2%), best-corrected visual acuity (27.4%), Visual Analogue Scale scores for frequency (32%) and severity (34%), and a significant improvement in the Schirmer test scores (177.5%) were observed (p < 0.05). The results were stratified according to the identified potential effect modifiers. Only four adverse events were reported. All of them were mild and resolved within a few days. Conclusions: Results suggest that PRGF eye drops could be a safe and effective treatment in reducing EDE signs and symptoms. When treating patients, the possible influence of some clinical variables must be taken into account.

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Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Autologous Plasma Rich in Growth Factors Eye Drops for the Treatment of Evaporative Dry Eye

Merayo‐Lloves

Sánchez-Ávila²,

Riestra³

et al. 2016

Ophthalmic Res

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“…In fact, it has been shown that plasma and platelet-based formulations show a potent antinociceptive activity linked, at least in part, to their endocannabinoids and related compound content, and to their ability to elevate the levels of these lipid mediators in cells [21]. Improvement in pain perception and in life quality has been reported in several randomized clinical trials, such as pain associated with knee osteoarthritis [22,23,24], postoperative pain associated with molar tooth extractions [25], and in some oral surgery procedures such as elevation of the maxillary sinus [26]. Moreover, this ‘analgesic' effect in OSDs may also be related to the NF-kB pathway-mediated anti-inflammatory effects of PRGF [17,27].…”

Section: Discussionmentioning

confidence: 99%

Autologous Plasma Rich in Growth Factors Eyedrops in Refractory Cases of Ocular Surface Disorders

et al. 2015

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Purpose: Preliminary information about the safety and efficacy of plasma rich in growth factors (PRGF) eyedrops in the treatment of refractory cases of diverse ocular surface disorders (OSDs) is presented here. Material and Methods: This retrospective cohort study included cases with OSDs refractory to previous treatment with conventional treatments or autologous serum or cyclosporine, and treated with PRGF eyedrops. The signs and symptoms of ocular surface disorders [using the ocular surface disease index (OSDI), best-corrected visual acuity (BCVA), visual analog scale (VAS) frequency and VAS severity] were evaluated before and after treatment with PRGF. A safety assessment was also performed reporting all adverse events or complications. Results: Forty-one patients with a total of 80 treated eyes were evaluated. Statistically significant reductions in the OSDI scale (39.27%), VAS frequency (38.9%) and VAS severity (40.3%), and a significant improvement in BCVA (54.86%) were all observed (p < 0.05). The results were stratified according to the identified potential effect modifiers. There were only two adverse events (eye redness and eyelid inflammation), which were reported as mild and resolved in a few days. Conclusions: PRGF eyedrops could be a safe and effective treatment option for refractory cases of OSDs. When treating patients the possible influence on the results of some clinical variables must be taken into account.

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“…Soft tissue healing was evaluated in five of the seven studies included [15,16,17,18,19]. A qualitative assessment of hard tissue healing was carried out in five of the seven included studies (supplemental table 1, available at http://content.karger.com/ProdukteDB/produkte.asp?doi=488061 ) [15,16,18,20,21]. …”

Section: Resultsmentioning

confidence: 99%

“…Four studies investigated the postoperative symptoms and quality of life (e.g. pain, complications) following to the surgical procedure as reported in supplemental table 1 (available at http://content.karger.com/ProdukteDB/produkte.asp?doi=488061 ) [15,16,19,20]. …”

Section: Resultsmentioning

confidence: 99%

The Role of Autologous Platelet Concentrates in Alveolar Socket Preservation: A Systematic Review

Annunziata

Guida

Nastri

et al. 2018

Transfus Med Hemother

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Prevention of alveolar bone resorption after tooth extraction may be useful for implant rehabilitation of the edentulous site minimizing the future need for bone augmentation procedures. A number of studies have investigated the efficacy of autologous platelet concentrates for the preservation of the alveolar bone volume after tooth extraction. Although encouraging results have been published, the available data are still controversial. The aim of the present systematic review was to assess the effect of platelet concentrates on alveolar socket preservation after tooth extraction. A literature search was carried out up to September 2017 for prospective controlled trials in which a test group using exclusively a platelet concentrate was compared with a control group in which extraction sockets were left to heal spontaneously. Seven controlled clinical trials published between 2010 and 2016 were included. A total of 320 extractions (170 tests and 150 controls) in 190 patients was considered. A great heterogeneity was found in terms of study design, methodological aspects, and outcome evaluation. For this reason, a quantitative analysis followed by meta-analysis was not possible, and only a descriptive analysis on the role of platelet concentrates in alveolar socket preservation was carried out. There is growing evidence that platelet concentrates may be advantageously used in postextraction sites, mainly to improve soft tissue healing and to reduce postoperative symptoms. Data about their potential in preserving the alveolar bone volume are still scarce and controversial, although recently encouraging results have been presented using more reliable and accurate evaluation technologies, such as the computed tomography. Further, well-designed and methodologically standardized investigations are strongly demanded to reach a higher level of evidence on this topic.

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Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial

Abstract: Plasma rich in growth factors could be a useful tool to enhance the healing of extraction sockets by minimizing postoperative complications and stimulating the hard and soft tissues regeneration.

Cited by 72 publications

References 29 publications

Safety and Efficacy of Autologous Plasma Rich in Growth Factors Eye Drops for the Treatment of Evaporative Dry Eye

Safety and Efficacy of Autologous Plasma Rich in Growth Factors Eye Drops for the Treatment of Evaporative Dry Eye

Autologous Plasma Rich in Growth Factors Eyedrops in Refractory Cases of Ocular Surface Disorders

The Role of Autologous Platelet Concentrates in Alveolar Socket Preservation: A Systematic Review

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