To assess the efficacy of socket plug technique using platelet rich fibrin with or without the use of bone substitute in alveolar ridge preservation: a prospective randomised controlled study

Chaudhary, Rupanzal; Kumar, Ish; Arora, Saryu; Kumar, Neeraj; Singh, Hem

doi:10.1007/s10006-018-0680-3

Cited by 34 publications

(43 citation statements)

References 26 publications

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“…On the contrary, a recent study showed no significant differences in terms of bone density and alveolar ridge dimensions for sockets treated with A‐PRF, FDBA or a combination of A‐PRF and FDBA (Clark, Rajendran, Paydar, Ho & Cox, ). Adding PRF to Plaster of Paris also did not return any significant benefit for ridge preservation (Girish Kumar, Chaudhary, Kumar, Arora & Kumar, ). When comparing PRF to β‐TCP with collagen in preserving the socket of single‐rooted teeth, similar outcomes were reported at 6 months (Das, Jhingran, et al.…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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“…Extraction sockets were carefully cleaned from any remains of granulation tissue. Flapless extractions were attempted, but if necessary flaps were elevated at the discretion of the Operator All regions Not reported Zhang et al [ 49 ] Parallel CCT 28 (14 females and 14 males) 14 14 34.6 Patients with upper and lower mandibular molars diagnosed as fractured tooth or could not be retained for other reasons Not reported All patients were treated with the non‑flap minimally invasive extraction technology Molars 3 months Kumar et al [ 43 ] RCT Parallel/Split 48 (not further specified) Not reported Not reported 44.4 Patients requiring tooth extraction Not reported All teeth were extracted atraumatically using periotomes and luxators without raising mucoperiosteal flap All regions Not reported Asmael et al [ 58 ] RCT split mouth 20 males 20 20 44.2 Smoker patient with multiple teeth extraction Not reported Extraction in atraumatic manner All regions Not reported Clark et al [ 39 ] Parallel RCT 45 enrolled 40 analyzed (22 females and 18 males) Test 1:10 Test2:10 Control1:10 Control2:10 58 Patients with single-rooted tooth requiring extraction and replacement with a dental implant supported restoration Teeth were excluded if they demonstrated a buccal dehiscence of more than 25% of the length of the tooth or presence of acute infection of endodontic origin Non-t...…”

Section: Resultsmentioning

confidence: 99%

Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

et al. 2021

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Purpose To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment? Methods After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included. Results 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing. Conclusions Based on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.

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“…The flap was raised in order to have good access to necrotic tissue as, well as to close the whole bony defect with soft tissues. It is worth mentioning that PRF can be applied together with other biomaterials, such as decalcified freeze-dried bone graft (DFDBA) or calcium sulfate to maintain the width of the bone ridge after tooth extraction [30,31,32]. In the presented case, it was decided not to use any bone substitute because of the risk of complications with soft tissue healing and, as a result, increased risk of infection and sequestration of the bone graft.…”

Section: Discussionmentioning

confidence: 99%

Application of platelet rich fibrin in the treatment of ingival and bone necrosis following the use of paraformaldehyde containing devitalizing paste

Janowska-Bugaj¹,

Szymacha²,

Lewkowicz³

2021

J Pre Clin Clin Res.

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Introduction. Paraformaldehyde has been used in endodontics when effective anaesthesia could not be achieved. However, this agent has many adverse effects including gingival, bone necrosis, osteomyelitis and allergy on account of systemic exposure. Therefore, the use of pastes containing paraformaldehyde should be avoided in contemporary dental practice. Objective. The aim of this case report was to present the application of platelet-rich fibrin(PRF) in combination with a coronally advanced flap in the treatment of gingival and bone necrosis associated with paraformaldehyde containing devitalizing paste toxicity. PRF is an autogenous resorbable membrane composed of platelets, cytokines, leukocytes and growth factors. Results and conclusions. Four weeks following burgery, the wound was completely healed with epithelial cells covering the interdental crater. On the basis of literature and of the present case, it can be stated that the use of PRF significantly reduces postoperative pain and promotes tissue healing.

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To assess the efficacy of socket plug technique using platelet rich fibrin with or without the use of bone substitute in alveolar ridge preservation: a prospective randomised controlled study

Cited by 34 publications

References 26 publications

The use of bioactive factors to enhance bone regeneration: A narrative review

The use of bioactive factors to enhance bone regeneration: A narrative review

Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

Application of platelet rich fibrin in the treatment of ingival and bone necrosis following the use of paraformaldehyde containing devitalizing paste

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