Comparative pharmacokinetics and bioavailability of oxytetracycline in giant tiger prawn

Sangrungruang, Koolvara; Chotchuang, Amornthep; Ueno, Ryuji

doi:10.1111/j.1444-2906.2004.00827.x

Cited by 17 publications

(22 citation statements)

References 20 publications

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“…, 1995; Reed et al. , 2004; Sangrungruang et al. , 2004; Uno, 2004), and these studies all show considerable variability in hemolymph drug concentrations.…”

Section: Resultsmentioning

confidence: 79%

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The complete analysis of oxytetracycline pharmacokinetics in farmed Pacific white shrimp (Litopenaeus vannamei)

Chiayvareesajja

Chandumpai²,

Theapparat³

et al. 2006

Vet Pharm & Therapeutics

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Lack of dosing information of the major antibiotics known as oxytetracycline (OTC) for the Pacific white shrimp (Litopenaeus vannamei) could have harmful impact on aquaculture in Thailand. The aim of this study was to detail complete pharmacokinetic information of OTC in the Pacific white shrimp. Sixty-four male L. vannamei weighing 14-22 g with carapace length of 2.30-3.00 cm in the standardized moulting stage of C-D(0) were used for the investigations. Single dose, 10 microg/g body weight OTC solution was administered intra-sinusally (i.s.), and the shrimps were then sampled in three replicates at time intervals of 0.25, 0.5, 2, 4, 6, 9, 12, 24, 48, 72, 170, 336 and 504 h postdose. OTC levels with time intervals in biological matrices including the hemolymph, abdominal muscle, and digestive gland of each sample were determined by validated high-performance liquid chromatography, and were analyzed with noncompartment and compartment models. A simplified two-compartment model was employed rather than a more complicated model, with additional digestive compartment if necessary. A significant portion of the OTC was found in the digestive glands, even though the OTC was administered i.s. The model indicated that the OTC was thus not only distributed into the tissue compartment, but also to the digestive gland, from where it was eliminated from the shrimp's body. The dispositional half-lives of all compartments was found to be 14-21 h. Approximately 60% of the drug elimination took place in digestive gland, which is proposed to be the major route of elimination.

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“…, 1995; Reed et al. , 2004; Sangrungruang et al. , 2004; Uno, 2004), and these studies all show considerable variability in hemolymph drug concentrations.…”

Section: Resultsmentioning

confidence: 79%

“…Several studies have reported previously that OTC pharmacokinetics in shrimps could be modeled as a two‐compartment study (e.g. Sangrungruang et al. , 2004; Uno, 2004).…”

Section: Resultsmentioning

confidence: 99%

The complete analysis of oxytetracycline pharmacokinetics in farmed Pacific white shrimp (Litopenaeus vannamei)

Chiayvareesajja

Chandumpai²,

Theapparat³

et al. 2006

Vet Pharm & Therapeutics

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“…Previous pharmacokinetic studies of OTC after intrasinus administration have been also analyzed by a two-compartment model in white shrimp (Penaeus (Litopenaeus) setiferus), kuruma shrimp (Penaeus (Marsupenaeus) japonicus) and P. monodon (Reed et al 2004;Sangrungruang et al 2004;Uno 2004;Uno et al 2006). In P. vannamei, the target species in this study, Chiayvareesajja et al (2006) have demonstrated both a two-and three-compartment models for OTC levels in hemolymph after intra-sinus dosing and made use of a two-compartment model for simplicity.…”

Section: Discussionmentioning

confidence: 99%

“…It has potential for use in farm-raised shrimp for the treatment of vibriosis like Vibrio alginolyticus and Vibrio harveyi. There are many studies on the pharmacokinetics and residues of OTC in marine and freshwater shrimp (Mohney et al 1997;Bermúdez-Almada et al 1999;Brillantes et al 2001;Uno 2002Uno , 2004Sangrungruang et al 2004;Reed et al 2004Reed et al , 2006Weifen et al 2004;Uno et al 2006;Poapolathep et al 2008a, b), but limited information of OTC dispositions in P. vannamei is available (Chiayvareesajja et al 2006;Nogueira-Lima et al 2006;Faroongsarng et al 2007;Gómez-Jimenez et al 2008). …”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Uno

Chaweepack²,

Ruangpan

2010

Aquacult Int

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The present study examined the pharmacokinetics and bioavailability of oxytetracycline (OTC) in vannamei shrimp (Penaeus vannamei) after intra-sinus (10 mg/kg) and oral (10 and 50 mg/kg) administration and also investigated the net changes of OTC residues in the shrimp after the thermal, acid and alkaline processing methods. The hemolymph concentrations of OTC after intra-sinus dosing were best described by a twocompartment open model. The oral bioavailability was found to be 48.2 and 43.6% at doses of 10 and 50 mg OTC/kg, respectively. The peak hemolymph concentrations after 10 and 50 mg OTC/kg doses were 3.37 and 17.4 lg/ml; the times to peak hemolymph concentrations were 7 and 10 h. The elimination half-lives were found to be 15.0 and 11.5 h for the low and high dose, respectively. The residual OTC was rapidly eliminated from muscle with the elimination half-life value of 19.4 and 15.4 h, respectively, for the groups treated with doses of 10 and 50 mg/kg. The residual OTC levels in the muscle fell below the MRL (0.2 lg/g) at 72 and 96-h post-dosing at dose levels of 10 or 50 mg/kg, respectively. Residual OTC levels in muscle and shell were approximately 20-50% lower in the thermal treatment such as boiling, baking and frying. By the acid treatment, OTC residues were reduced to [80%, while those were reduced to around 30% by alkaline treatment.

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“…For instance, the MRL for OTC is 0.1 mg/g in the EU, 0.2 mg/g in the United States, and 0.2 mg/g in Japan in edible tissues [53,56]. There have been a number of studies of OTC pharmacokinetics in penaeid shrimp [47,53,[56][57][58][59][60][61]. The concentration of OTC in blue shrimp (Litopenaeus stylirostris) treated with 1.5 g OTC/kg food for 14 d remained between 3.3 and 5.2 mg/g of shrimp tail muscle from day 4 through day 14 of the feeding period.…”

Section: Antibiotic Residues In Penaeid Shrimpmentioning

confidence: 99%

Effects of pesticides and antibiotics on penaeid shrimp with special emphases on behavioral and biomarker responses

Silvestre

Phương

et al. 2010

Enviro Toxic and Chemistry

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Abstract-The purpose of the present study is to provide information on the current state of knowledge regarding the effects of pesticides and antibiotics used in aquaculture on penaeid shrimp, one of the most common aquatic products for human consumption, with a special emphasis on the use of behavioral, physiological, and biochemical response. These include behavior; feeding rate changes; respiration rate, oxygen consumption, and osmoregulation alterations; nucleic acids, protein, and glycogen synthesis; cholinesterase activity inhibition; ATPase activity; and oxidative stress responses. This paper also deals with residues of antibiotics and pesticides in penaeid shrimp. Antibiotics and pesticides used in aquaculture may have adverse effects on treated animals and human consumers health if they are not correctly used. As a complement to the measurement of antibiotic and pesticide residues in tissues, the use of behavioral and biomarker responses can provide more relevant biological information on the potential adverse effects of antibiotics and pesticides on penaeid shrimp health. Environ. Toxicol. Chem. 2010;29:929-938. # 2009 SETAC

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Comparative pharmacokinetics and bioavailability of oxytetracycline in giant tiger prawn

Cited by 17 publications

References 20 publications

The complete analysis of oxytetracycline pharmacokinetics in farmed Pacific white shrimp (Litopenaeus vannamei)

The complete analysis of oxytetracycline pharmacokinetics in farmed Pacific white shrimp (Litopenaeus vannamei)

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Effects of pesticides and antibiotics on penaeid shrimp with special emphases on behavioral and biomarker responses

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