Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Uno, Kazuaki; Chaweepack, Tidaporn; Ruangpan, Lila

doi:10.1007/s10499-009-9318-7

Cited by 17 publications

(12 citation statements)

References 28 publications

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“…If chitin is made from shrimp shells containing the residual antimicrobials, it is doubtful whether the chitin products are safe as food (particularly, functional health food) materials. In our recent work (Uno et al, 2010), the OTC residues in shrimp shells were considerably reduced (>80%) by hydrochloric acid treatments, whereas those were reduced to 30% by alkaline treatment. Currently, the industrial extraction process of chitin from shrimp shells consists of two basic steps: demineralization by acid treatment such as HCl; and deproteinization by alkaline treatment such as NaOH (Percot et al, 2003).…”

Section: Introductionmentioning

confidence: 85%

“…The extraction method of OTC was previously described (Uno et al, 2006a;2010). Briefly, samples (0.5 g) were homogenized with 30 ml of 5% trichloroacetic acid containing 0.5% EDTA and centrifuged for 20 min at 12,000 rpm.…”

Section: Analytical Proceduresmentioning

confidence: 99%

“…The extraction procedures of OA were carried out by our previous method (Uno et al, 2006b). Samples (0.5 g) were homogenized with 30 ml of 0.2% metaphosphoric acid-methanol (7:3) and centrifuged at 12,400 x g for 20 min.…”

Section: Analytical Proceduresmentioning

confidence: 99%

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Uno¹,

Higashimoto²,

Chaweepack³

et al. 2012

Turk. J. Fish. Aquat. Sci.

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The present study examined the influences of industrial chitin extraction processes on the residual oxytetracycline (OTC) and oxolinic acid (OA) in shrimp carapaces and shells. The drugs were orally administered by catheter to the kuruma shrimp (Penaeus japonicus) and vannamei shrimp (Penaeus vannamei). The shrimps were sampled at 6-h post-dosing and their carapaces and shells were collected and used as raw material in the chitin extraction. Residual OTC levels in raw materials were 9 -18 fold higher than the maximum residue limit (MRL) (0.2 µg/g). The residual OTC was reduced 10 -30% by washing treatment. By the acid treatment with HCl, the OTC residues were reduced >98%. The deproteinized material contained negligible levels of OTC. Residual OA levels in raw materials was much higher (134 -376 fold) than the MRL (0.03 µg/g). The residual OA was reduced considerably (34 -68%) by washing treatment. By the demineralization, the residual OA could not be detected in both shrimp carapaces, while the levels of OA residues were determined more than MRL in shells. In the deproteinized materials, no residual OA were detected. Finally, residual OTC and OA could not be detected in the chitin materials for both shrimps.

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Section: Introductionmentioning

confidence: 85%

Section: Analytical Proceduresmentioning

confidence: 99%

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Uno¹,

Higashimoto²,

Chaweepack³

et al. 2012

Turk. J. Fish. Aquat. Sci.

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“…Consequently, there is an urgent need to minimize OTC use in aquaculture not only because of the environmental impact but also for human health reasons. Pharmacokinetic data is essential to improve treatment efficacy and minimize dosage (Grondel et al., ; Ueno et al., ; Malvisi et al., ; Namdari et al., , ; Abedini et al., ; Rigos et al., , ; Zhang and Li, ; Uno et al., ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of oxytetracycline in yellow catfish [Pelteobagrus fulvidraco (Richardson, 1846)] with a single and multiple-dose oral administration

Yuan

Shi

et al. 2013

J. Appl. Ichthyol.

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Summary A pharmacokinetic study of oxytetracycline (OTC) following a single (100 mg kg−1) or a multi‐dose (100 mg kg−1 for 5 days) oral administration was carried out in yellow catfish, Pelteobagrus fulvidraco. After oral administration at 25°C, a one‐compartment model was developed. The absorption half‐life (t1/2(ka)) was 3.92, 1.44, 2.75, and 3.34 h in plasma, muscle, liver, and kidney after the single dose, and 0.35, 0.22, 0.42, 0.32 h after the multi‐dose, respectively. The order of peak concentration (Cmax) was liver > kidney > plasma > muscle, at 3.48 μg g−1, 2.90 μg g−1, 1.46 μg ml−1, and 1.39 μg g−1 after the single dose, and 14.02 μg g−1, 8.51 μg g−1, 4.17 μg ml−1, and 3.84 μg g−1 after the multi‐dose, respectively. The elimination half‐lives (t1/2(ke)) of OTC in plasma, muscle, liver, and kidney were calculated to be 7.64, 26.29, 19.08, and 10.61 h after the single dose, and 47.54, 70.99, 49.87, and 47.73 h after the multi‐dose, respectively. The results suggest that OTC was absorbed faster after the multi‐dose than after the single dose, suggesting that OTC could be more efficacious after the multi‐dose and more effective in the control bacterial diseases in aquaculture, with the side effects of longer withdrawal periods.

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“…To name some: The USA, the European Union and Japan set values at 0.2, 0.1 and 0.2 µg/g for the edible portions of the aquatic animals, respectively (Tu et al ). There is evidence that OTC is present in the shrimp shell (Uno et al ) even after receiving a dose of as low as 10 mg/kg‐body weight (BW) (Uno et al ). In the process of growth, the shrimp shell is shed from time to time and these old exoskeletons that could contain the antibiotic remain in the culture ponds and become dispersed in the environment.…”

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confidence: 99%

The Complete Analysis of the Distribution Kinetics of the Oxytetracycline Antibiotic in the Exoskeleton of Farmed Pacific White Shrimp, Litopenaeus vannamei

Faroongsarng¹,

Chiayvareesajja²,

Theapparat³

2013

J World Aquaculture Soc

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Oxytetracycline (OTC) in shrimp shells may be dispersed to the environment as shrimp shred old cuticle in growout ponds. The study aims to assess the kinetics of OTC accumulated in shrimp shell. Sub-adult male Litopenaeus vannamei in the C-D 0 molting stage, were force fed with medicated feeds at various accurate dose levels that included 50, 500 and 1000 mg/kg-body weight (BW). In addition to hemolymph, hepatopancreas and muscle were serially collected for 50 mg/kg-BW-dose group while cuticle was sampled for higher dose levels. All were assayed for OTC by a validated high-performance liquid chromatography (HPLC) method. Mineral contents in shell samples of 500 mg/kg-BW-dose were also determined. The bioavailability markedly decreased with increasing dose due to incomplete dissolution and/or mild dysfunction in absorption. Administered doses, 2.69 and 2.25%, ended up in the shell after dosing with 500 and 1000 mg/kg-BW, respectively. OTC data after a dose of 50 mg/kg-BW was fitted into a three-compartment model with an added shell compartment with r 2 of 0.9920. The model was successfully extrapolated to predict OTC distribution in shell at higher doses. In addition, there was evidence that OTC may disturb the biomineralization process via complex formation with calcium and magnesium lowering the exoskeleton mineral contents.

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Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Cited by 17 publications

References 28 publications

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Pharmacokinetics of oxytetracycline in yellow catfish [Pelteobagrus fulvidraco (Richardson, 1846)] with a single and multiple-dose oral administration

The Complete Analysis of the Distribution Kinetics of the Oxytetracycline Antibiotic in the Exoskeleton of Farmed Pacific White Shrimp, Litopenaeus vannamei

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