Pharmacokinetics of oxytetracycline in yellow catfish [Pelteobagrus fulvidraco (Richardson, 1846)] with a single and multiple-dose oral administration

Abstract

Summary A pharmacokinetic study of oxytetracycline (OTC) following a single (100 mg kg−1) or a multi‐dose (100 mg kg−1 for 5 days) oral administration was carried out in yellow catfish, Pelteobagrus fulvidraco. After oral administration at 25°C, a one‐compartment model was developed. The absorption half‐life (t1/2(ka)) was 3.92, 1.44, 2.75, and 3.34 h in plasma, muscle, liver, and kidney after the single dose, and 0.35, 0.22, 0.42, 0.32 h after the multi‐dose, respectively. The order of peak concentration (Cmax) was liver > kidney > plasma > muscle, at 3.48 μg g−1, 2.90 μg g−1, 1.46 μg ml−1, and 1.39 μg g−1 after the single dose, and 14.02 μg g−1, 8.51 μg g−1, 4.17 μg ml−1, and 3.84 μg g−1 after the multi‐dose, respectively. The elimination half‐lives (t1/2(ke)) of OTC in plasma, muscle, liver, and kidney were calculated to be 7.64, 26.29, 19.08, and 10.61 h after the single dose, and 47.54, 70.99, 49.87, and 47.73 h after the multi‐dose, respectively. The results suggest that OTC was absorbed faster after the multi‐dose than after the single dose, suggesting that OTC could be more efficacious after the multi‐dose and more effective in the control bacterial diseases in aquaculture, with the side effects of longer withdrawal periods.

Pharmacokinetics of oxytetracycline in hybrid catfish (Clarias macrocephalus x C. gariepinus) after intravascular and oral administrations

“…OTC in the hybrid catfish had a higher value for C max (2.72 µg/mL) than reported in yellow catfish (1.46 µg/mL) [ 21 ] and sea bream (2.5 µg/mL) [ 18 ], while it was lower than that of Arctic char (3.93 µg/mL) [ 22 ] and black sea bream (8.48 µg/mL) [ 24 ] after PO administration at a dosage of 50 mg/kg BW ( Table 2 ). Additionally, the T max value of OTC in hybrid catfish (8 h) was quite similar in yellow catfish (7.75 h) [ 21 ], while it was lower than in Japanese eel (24 h) [ 23 ] after PO administration.…”

“…The plasma was separated using centrifugation (1,986 × g ) for 15 min and immediately stored at −20°C for 2 weeks before analysis. The dose of OTC used in this study was according to the study of pharmacokinetics in the yellow catfish [ 21 ].…”

“…There have been reports regarding using OTC in fish species, including rainbow trout ( Oncorhynchus mykiss ) [ 11 12 ], channel catfish [ 13 ], Atlantic salmon ( Salmo salar ) [ 14 ], chinook salmon ( Oncorhynchus tshawytscha ) [ 15 ], yellow perch ( Perca flavescens ) [ 16 ], sea bass ( Dicentrarchus labrax ) [ 17 ], sea bream ( Sparus aurata ) [ 18 ], grass carp ( Ctenopharyngodon idellus ) [ 19 ], tilapia ( Oreochromis spp.) [ 20 ], yellow catfish ( Pelteobagrus fulvidraco ) [ 21 ], Arctic char ( Salvelinus alpinus ) [ 22 ], Japanese eel [ 23 ], and black sea bream ( Sparus macrocephalus ) [ 24 ]. However, to date, there has been no report regarding pharmacokinetic characteristics in the hybrid catfish ( C. macrocephalus x C. gariepinus ) after single intravascular (IV) or oral (PO) administrations.…”

Pharmacokinetics studies of eugenol in Pacific white shrimp (Litopenaeus vannamei) after immersion bath

“…Compared to the peak concentrations in single-dose administration, higher values could be observed in multiple-dose administration in a lot of drugs. The oxytetracycline peak concentrations were 14.02, 8.51, 4.17, 3.84 μg/g in plasma, muscle, liver and kidney in Pelteobagrus fulvidraco after the multiple-dose oral administration, which were much higher than 1.46, 1.39, 3.48 and 2.90 μg/g after the single dose oral administration [ 61 ]. Two point seventy-seven microgram per gram of enrofloxacin was detected in muscle of giant freshwater prawns at the dose of 5 g/kg for 5 days, while peak muscle concentration was 1.98 μg /g at a single dosage of 10 mg/kg [ 62 ].…”

Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus

“…Although the drug concentrations were low in flesh and plasma, high levels were detected in the liver and kidneys suggesting rapid distribution of the drug from blood to these organs. OTC has an absorption half‐life of 0.22–0.42 hr and attains peak concentrations at 1.86–2.91 hr of multi‐dose oral dosing in different tissues of yellow catfish Pelteobagrus fulvidraco (Yuan et al, 2014). In present work tissue samples were collected on 3–4 hr of similar multi‐dose administration ascertaining maximum absorption and presence of the antibiotic in different tissues.…”