Comparative Morphological Characterization of the Human Brainstem in the First Period of Mature and Old Age

Abstract

The knowledge of brain aging patterns, in particular its trunk, is necessary for understanding age-related compensatory resources of the body's nervous tissue. Objective: to determine the human brain stem volume in the first period of mature age and in old age using magnetic resonance imaging (MRI) and to compare these parameters in age-related aspect. Material and methods: we analyzed the results of brainstem morphometric study of 94 people (48 men and 46 women) using MRI, who underwent brain examination in the Department of Radiation Diagnostics in the period 2019–2021. Criteria for inclusion of subjects in the study: the first period of mature age or old age of the subject; craniotype – mesocranial; history without diseases and injuries of both central and peripheral nervous system organs, exclusion of drug and alcohol addiction; absence of signs of pathology of brain departments detected during the study. Results: MRI of the brain stem revealed a statistically significant decrease of its volume indices both in men and in women by senile age (p < 0,01). There was revealed a tendency for predominance of brain stem volume indices in men both in the first period and old age in comparison with women without statistically reliable difference (p > 0,05). The obtained results will serve as a basis for understanding age-related anatomical changes of the brain stem and allow more accurate diagnostics of patients in the conditions of personalized medicine

Возрастные Изменения Объема Ствола Мозга В Пожилом И Старческом Возрасте

“…Причины и последствия старения отделов центральной нервной системы изучены достаточно, но анатомические данные о структурах мозга в возрастном аспекте, а именно об изменениях объема ствола мозга представлены незначительно [9,10,11]. Установлена тенденция к превалированию параметров объема ствола у мужчин и женщин пожилого возраста в сравнении с представителями старческого возраста.…”