Comparative in vitro activity of semisynthetic penicillins against Proteeae

Hawkey, Peter M.; Pedler, S.J.; Turner, Anne C.

doi:10.1128/aac.23.4.619

Cited by 18 publications

(14 citation statements)

References 10 publications

(3 reference statements)

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“…The sensitivity to antimicrobials shown in Table 5 reveals the isolates to be similar in their sensitivity profiles to those reported in surveys of hospital isolates of Proteeae Hawkey, Pedler & Turner, 1983). Although only a small number of biogroup-2 Prot.…”

Section: Discussionsupporting

confidence: 56%

Speciation, serotyping, antimicrobial sensitivity and plasmid content of Proteeae from the environment of calf-rearing units in South West England

Hawkey

Penner

Linton

et al. 1986

J. Hyg.

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rettgeri. A wide range of serotypes was found, many having been previously reported from nosocomial isolates. A total of 15 % of isolates carried plasmids; six pairs of isolates were identified which had identical serotypes but different patterns of plasmid carriage. The antimicrobial sensitivity of the isolates was generally similar to isolates of Proteeae from humans. Although no truly aminoglycosideresistant isolates were found, some isolates of Prov. stuartii and Prov. rettgeri had MIC's higher than the other isolates to gentamicin and netilmicin, suggesting the presence of low levels of the enzyme AAC 2'. The study demonstrates that there is a considerable diversity of species and types of Proteeae associated with calves and their environment. It seems likely that a potential cause of colonization of the human gut by Proteeae is the consumption of meat.

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Section: Discussionsupporting

confidence: 56%

Speciation, serotyping, antimicrobial sensitivity and plasmid content of Proteeae from the environment of calf-rearing units in South West England

Hawkey

Penner

Linton

et al. 1986

J. Hyg.

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“…This behavior was consistent with previously reported antimicrobial susceptibilities to carbenicillin (4,5). Moreover, the higher resistance of P. penneri to cefuroxime clearly separated it from the other six species.…”

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confidence: 93%

“…In conclusion, the results of this in vitro study authorize us to affirm, in agreement with Hawkey et al (4), that accurate identification to the species level of isolates of Proteeae in surveys of susceptibilities to antimicrobial agents is essential if potentially misleading results are not to be reported. This work was supported by grant 86.01619.52 from the Consiglio Nazionale delle Ricerche (Italy).…”

supporting

confidence: 90%

Comparative in vitro activities of 13 antimicrobial agents against Morganella-Proteus-Providencia group bacteria from urinary tract infections

Piccolomini

Cellini

Allocati

et al. 1987

Antimicrob Agents Chemother

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We examined 741 urinary tract isolates of the Morganella-Proteus-Providencia group, including the recently defined species Proteus penneri, for susceptibilities to aminoglycosides, semisynthetic penicillins, and cephalosporins. The data emphasize the importance of identification to the species level on the basis of marked species differences in patterns of susceptibility.During the last few years, an increase in the frequency of antibiotic resistance among the Proteeae has been noted (4, 11). Therefore, continued concern about antimicrobial resistance is warranted, as are studies on the activities of new agents. Unfortunately, in studies of in vitro susceptibility, species of Proteeae are often divided into Proteus mirabilis, indole-positive Proteus spp., and Providencia spp. It has been shown that such broad groupings conceal major differences among species in susceptibilities to antimicrobial agents (11).For these reasons, we decided to perform a study of the in vitro susceptibilities of recently and precisely identified isolates of the Morganella-Proteus-Providencia group, including the recently defined species Proteus penneri (3, 5, 6, 9), by standardized susceptibility testing methods performed in our laboratory.A comparison was made between the in vitro activities of amikacin, tobramycin, carbenicillin, azlocillin, piperacillin, temocillin, cefazolin, cefoxitin, and cefuroxime and four newly developed preparations: aztreonam, imipenem, ceftazidime, and ceftriaxone.Laboratory-grade, antibiotic-standard powders were obtained from the manufacturers as follows: azlocillin, Bayer AG, Leverkusen-Bayer Italia, Milan, Italy; ampicillin, carbenicillin, and temocillin,

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“…Cefoxitin was only slightly more active against P. penneri (MIC90, 4 ,ug/ml) than against P. vulgaris (MIC90s, 6.25, 8, 16, 32, and 50 ,ug/ml [references 1, 5, 9, 13, and 18, respectively]). In a recent report, P. penneri strains were reported to be more resistant to the newer semisynthetic ureidopenicillins, azlocillin and mezlocillin (3). However, in our study, P. penneri strains were generally found to be susceptible to piperacillin (MIC90, 16 ,ug/ml).…”

contrasting

confidence: 74%

Susceptibilities of 45 clinical isolates of Proteus penneri

Fuksa¹,

Krajden²,

Lee³

1984

Antimicrob Agents Chemother

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Patterns of susceptibility of 45 Proteus penneri clinical isolates to 14 antimicrobial agents were evaluated by a macrobroth dilution method. All strains were highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, netilmicin, and, with few exceptions, to amikacin, piperacillin, and cefoperazone. Most strains were susceptible to cefotaxime and ceftriaxone. All strains were resistant to cefazolin and cefsulodin.

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Comparative in vitro activity of semisynthetic penicillins against Proteeae

Cited by 18 publications

References 10 publications

Speciation, serotyping, antimicrobial sensitivity and plasmid content of Proteeae from the environment of calf-rearing units in South West England

Speciation, serotyping, antimicrobial sensitivity and plasmid content of Proteeae from the environment of calf-rearing units in South West England

Comparative in vitro activities of 13 antimicrobial agents against Morganella-Proteus-Providencia group bacteria from urinary tract infections

Susceptibilities of 45 clinical isolates of Proteus penneri

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