Susceptibilities of 45 clinical isolates of Proteus penneri

Abstract

Patterns of susceptibility of 45 Proteus penneri clinical isolates to 14 antimicrobial agents were evaluated by a macrobroth dilution method. All strains were highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, netilmicin, and, with few exceptions, to amikacin, piperacillin, and cefoperazone. Most strains were susceptible to cefotaxime and ceftriaxone. All strains were resistant to cefazolin and cefsulodin.

Urease activity of Proteus penneri

“…Proteus penneri is a newly described 7, multipleantibiotic.resistant (1,2,6) bacterial species that has been isolated from a variety of clinical sources including stool, urine, and wounds (10,14). The presence of the organism has been frequently associated with the use of an indwelling bladder catheter (10) and has been reported as the cause of urinary calculus formation in one patient with P. penneri bacteriuria (9).…”

Analysis of antibiotic resistance determinants inProteus penneri

“…They also tend to be more resistant to quinolones and semi-synthetic penicillins (5)(6)(7)(8), resistance in the latter case being due to the unique cephalosporinase produced by this organism (9). The molecular mechanisms underlying these differences are not known, and the responsible genes have not been localized.…”

Expanded clinical spectrum of infections caused by Proteus penneri

“…The authors had only 20 strains, for which there was little information on clinical significance. This prompted laboratories to examine isolates of the species to determine more precisely their susceptibilities to antibiotics, their biochemical reactions, and their particular role in human infections (1,4,6,7). In addition to their resistance to chloramphenicol, a species characteristic (2), they have been found typically resistant to cefazolin and cefsulodin; a few strains are also resistant to amikacin, piperacillin, and cefoperazone (1).…”

“…This prompted laboratories to examine isolates of the species to determine more precisely their susceptibilities to antibiotics, their biochemical reactions, and their particular role in human infections (1,4,6,7). In addition to their resistance to chloramphenicol, a species characteristic (2), they have been found typically resistant to cefazolin and cefsulodin; a few strains are also resistant to amikacin, piperacillin, and cefoperazone (1). Most strains are susceptible to cefotaxime and ceftriaxone, and all strains tested have been found highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, and netilmicin (1).…”

“…In addition to their resistance to chloramphenicol, a species characteristic (2), they have been found typically resistant to cefazolin and cefsulodin; a few strains are also resistant to amikacin, piperacillin, and cefoperazone (1). Most strains are susceptible to cefotaxime and ceftriaxone, and all strains tested have been found highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, and netilmicin (1). An interesting observation in one study (6) was that all P. penneri and 26% of the Proteus mirabilis isolates produced a green color reaction with Kovacs reagent, indicating that tryptophan is metabolized by these bacteria in a manner different from that of the indole-positive members of the tribe Proteeae.…”