Comparative immunohistochemical study of ameloblastoma and ameloblastic carcinoma

Yoon, Hae-Sung; Jo, Byoung-Chan; Shin, Wui-Jung; Cho, Young-Ah; Lee, Jae‐Il; Hong, Sam-Pyo; Hong, Seong‐Doo

doi:10.1016/j.tripleo.2011.06.036

Cited by 61 publications

(49 citation statements)

References 42 publications

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“…Most of our specimens show moderate to strong expression intensity. Yoon et al [25] also found that ameloblastoma has Age range of the patients was 11-58 years with mean age of 35.4 year moderate to strong intensity of MMP-9 expression. The detection results of constant expression in all of specimens lead us to the presumption that MMP-9 played an essential role in development and progression of ameloblastoma and may be associated with bone resorption cause by ameloblastoma.…”

Section: Discussionmentioning

confidence: 91%

Matrix Metalloproteinase-9 (MMP-9) Expression in Different Subtypes of Ameloblastoma

Anne

Krisnuhoni

Chotimah

et al. 2013

J. Maxillofac. Oral Surg.

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Background Ameloblastoma is a common benign odontogenic tumor of the jaw with a local invasive and highly destructive behavior and can develop in any age, with peak prevalence in 3rd-4th decade. Ameloblastoma can be divided into six histological types: follicular, plexiform, acanthomatous, desmoplastic, granular, and basal cell. Matrix metalloproteinase-9 (MMP-9) (92-kD gelatinase/ type IV collagenases = gelatinase B) is involved in bone resorption by degradation of extracellular matrix and osteoclasts recruitment. Recent studies have found that MMP-9 is expressed by ameloblastoma and has a role in ameloblastoma local invasiveness. Objective To analyze MMP-9 expression between different histological types of ameloblastoma. Material and Method Forty samples of ameloblastoma were collected through consecutive sampling and the MMP-9 expression was detected using immunohistochemistry. Result All samples showed positive MMP-9 expression with moderate to strong intensity. 82.4 % plexiform type and 83.3 % mixed type have strong immunoexpression, significantly different with follicular type with only 36.4 % (P \ 0.05). Conclusion Ameloblastoma plexiform and mixed type have higher MMP-9 expression than ameloblastoma follicular type. Different MMP-9 expression may contribute in different ameloblastoma biological behavior.

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Section: Discussionmentioning

confidence: 91%

Matrix Metalloproteinase-9 (MMP-9) Expression in Different Subtypes of Ameloblastoma

Anne

Krisnuhoni

Chotimah

et al. 2013

J. Maxillofac. Oral Surg.

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“…Variations in proliferation rate in the various ameloblastoma subtypes have been reported, with both peripheral and desmoplastic ameloblastoma showing lower Ki-67 labelling indices [13][14][15][16]. Overall, however, all ameloblastomas have been shown to have a very low proliferative index (Fig.…”

Section: Neoplastic Odontogenic Epitheliummentioning

confidence: 91%

“…CK14 and CK19 expression) is largely similar in ameloblastic carcinoma and has no diagnostic utility (Fig. 3a-e) [16]. Many other reports centre on the proliferation fraction as a means of distinguishing these two entities.…”

Section: Malignant Odontogenic Tumorsmentioning

confidence: 98%

“…However, while all show a higher Ki-67 proliferation fraction in ameloblastic carcinoma than in ameloblastoma, the reported rates vary from 2.9-14.9 % in ameloblastoma and 8-48.7 % in ameloblastic carcinoma (compare Figs. 1f, 3f) [14][15][16]. This means that while a focal area of increased Ki-67 expression in a given tumor may suggest progression to malignancy, it is not possible to give even an estimate of a cut-off percentage to help make a diagnosis of ameloblastic carcinoma, except if the fraction is uniformly very high (e.g.…”

Section: Malignant Odontogenic Tumorsmentioning

confidence: 99%

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The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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The diagnosis of odontogenic tumors can be challenging, largely due to their rarity and consequent difficulties in gaining experience in their assessment. In most cases, careful attention to morphology, in conjunction with clinical and radiological features will allow a diagnosis to be made. However, in some cases, immunohistochemical analysis of the tumor may be useful. In this review we will outline the immunohistochemical expression profile of normal developing odontogenic tissues and a range of odontogenic tumors. In many cases the immunohistochemical markers are neither specific nor sensitive enough to be of help in diagnosis, but in some cases such analysis may prove very useful. Thus we have outlined a limited number of circumstances where immunohistochemistry may be of use to the practicing diagnostic pathologist.

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“…Desmoplastic ameloblastoma and clear cell ameloblastoma are considered to be more aggressive [1]. In recent years, many researchers published and reviewed the immune profile and genotyping of different variants of AB [20][21][22][23]. Additional work will be necessary to identify that one specific for the mucous ameloblastoma in order to determine its biological behavior and predicate outcome.…”

Section: A) C) B)mentioning

confidence: 99%

New Features in Mucous-Ameloblastoma. A Case Report of rare Entity

Gataa¹,

Garib²,

Rashid³

2015

Int J Oral Craniofac Sci

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Histologically ameloblastoma showed various forms of metaplastic changes. Evidence of mucous cells is a rare finding and only 9 cases were reported. We present a case of 80 year old male suffered from mandibular swelling for five years duration diagnosed as mucous ameloblastoma. Histopathological examination revealed a lot of mucous pools within the growth, a thin fibrous capsule surrounding the mass and a direct connection between growth islands and oral mucosa. This case highlights the features of rare type of ameloblastoma.2014) seeking help and treatment because the mass became larger and start to interfere with eating and speaking. On the presentation, the patient had extensive right side mandibular expansion; measuring 7X5 cm ( Figure 1A). There was no paresthesia of the mandibular nerve and no trismus. The swelling exhibited diffuse margins and was painless and do not adhere to the overlying skin.Intra orally, there was diffused swelling extending in an edentulous area from the distal surface of the mandibular right canine to the ramus anterio-posteriorly obliterating the right buccal vestibule. The central area of the overlying mucosa showed large deep necrosis, the remaining mucosa stretched and erythematous ( Figure 1E). There was no lymph node palpable in the neck.Orthopantomography and CT examination revealed a large, welldefined unilocular radiolucency with a scalloped border and central septa. It extends from mandibular right edentulous premolar area to the ramus ( Figure 1B and 1C).A diagnosis of ameloblastoma was considered depending on the clinical, radiographic, and previous histopathological report of the lesion. Subsequently, it was removed by surgical excision as an en bloc resection (hemi mandibulectomy, Figure 1D), and the surgical specimen submitted for histologic examination.Macroscopically, the surgical specimen is the right half of the mandible (from midline to the condyle). Only anterior teeth were present. The specimen measured 12X9 cm, (including the condyle head). The mass was grayish-white in color, rubbery with a smooth surface and was well separated from the bone at posterior border, fixed in formalin. The specimen sliced, and several samples were taken for histologic examination (one from the anterior bony margins). The cut surface showed nodular white-yellowish areas and numerous focal cystic spaces of variable sizes oozing thick mucinous material. The mass was well capsulated by thin smooth continues wall ( Figure 1F). Microscopic examination revealed numerous odontogenic

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Comparative immunohistochemical study of ameloblastoma and ameloblastic carcinoma

Cited by 61 publications

References 42 publications

Matrix Metalloproteinase-9 (MMP-9) Expression in Different Subtypes of Ameloblastoma

Matrix Metalloproteinase-9 (MMP-9) Expression in Different Subtypes of Ameloblastoma

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

New Features in Mucous-Ameloblastoma. A Case Report of rare Entity

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