2009
DOI: 10.4102/ojvr.v76i4.21
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Comparative histopathology of the lymph nodes, spleen, liver and kidney in experimental ovine trypanosomosis

Abstract: <span style="font-family: arial,helvetica;">The infection of Yankassa rams with three important trypanosome species affecting livestock, namely, <em>Trypanosoma congolense, T. vivax and T. brucei </em>produced both acute and chronic fatal conditions. Chronic infections were induced in the three infections by the application of subcurative doses of diaminazene aceturate (Berenil&reg;). Pathological changes in the infected animals included splenomegaly and hepatomegaly which were more prono… Show more

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Cited by 10 publications
(7 citation statements)
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“…In this study, hyperplasia of the red pulp, enlargement of the lymphoid nodules and proliferation of plasma cells were the lesions seen in the spleen in all infected groups is in agreement with the finding of Omotainse and Anosa [ 42 ]. Neuronal necrosis with shrunken angular neuron, pyknosis, perivasculatis, mononuclear cell infiltration like lymphocytes, plasma cells and macrophages were the lesions seen in the brain which might be associated the presence of parasites in the brain tissue (Fig.…”
Section: Discussionsupporting
confidence: 92%
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“…In this study, hyperplasia of the red pulp, enlargement of the lymphoid nodules and proliferation of plasma cells were the lesions seen in the spleen in all infected groups is in agreement with the finding of Omotainse and Anosa [ 42 ]. Neuronal necrosis with shrunken angular neuron, pyknosis, perivasculatis, mononuclear cell infiltration like lymphocytes, plasma cells and macrophages were the lesions seen in the brain which might be associated the presence of parasites in the brain tissue (Fig.…”
Section: Discussionsupporting
confidence: 92%
“…The lesions in the lymph nodes of trypanosome infected animals included increased presence of plasma cell populations, and the perivascular mononuclear cell infiltration, mainly of lymphocytes, plasma cells and macrophages, hepatocyte degeneration and hyperplasia in the liver were the common feature in the present findings. These changes accord to the findings described by Omotainse and Anosa [ 42 ] in ovine infected with T. vivax , T. congolense and T. brucei . This might have played a significant role in the inability of the animals to successfully recover from the anaemia experienced in trypanosomosis [ 42 ].…”
Section: Discussionsupporting
confidence: 92%
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“…Although we did not study the possible histopathological changes due to vitamin D 3 treatment, similar phenomena were observed by one of the authors in the murine experimental malaria (KY, manuscript in preparation). Probably, T. b. brucei infection could produce acute and chronic fatal conditions just like splenomegaly to the host [ 29 ]. On the other hand, polyphenon-60 has been shown to have toxic effects when administered in high doses to mice, where they induce reactive oxygen species formation, and affect mitochondrial membrane potential thereby causing death [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, both parasite models share two prominent pathogenic features in common, i.e. liver pathogenicity and anemia development (Moulton and Sollod 1976 ;Omotainse and Anosa 2009 ), whereby in particular the latter is one of the most prominent immunopathogenic features of both bovine and murine African trypanosomiasis. In this context, hosts displaying severe disease symptoms and pathogenicity are termed trypanosusceptible or susceptible, while hosts exhibiting an infection with low pathogenicity are referred to as trypanotolerant or resistant (Taylor 1998 ).…”
Section: Introductionmentioning
confidence: 99%