Comparative Histomorphometric Analysis of Maxillary Sinus Augmentation With Deproteinized Bovine Bone and Demineralized Particulate Human Tooth Graft

Xu, Xiping; Sohn, Dong-Seok; Kim, Hyung-Gyun; Lee, Sang Jae; Moon, Yun-Seob

doi:10.1097/id.0000000000000755

Cited by 14 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present review included 167 subjects (136 human, 26 rabbits and 5 mini-pigs) tested in 4 human studies and 3 animal model studies, which were published between 2013 and 2018. The study designs were as follows: 2 prospective observational studies (Jun et al [15], Kim et al [18]); 2 retrospective observational studies (Jeong et al [16], Kim et al [17]) and 3 animal clinical studies (Lee et al [19], Sohn et al [20], Xu et al [21]). The follow-up period ranged from 4 months to 2 years in human studies and 8 to 12 weeks in animal studies.…”

Section: Resultsmentioning

confidence: 99%

“…New bone formation in rabbits maxillary sinus after augmentation with demineralized particulated human tooth graft (DHT) was evaluated by comparing its histomorphometric outcomes to sinus augmented with Bio-Oss ® (deproteinized bovine bone) in a study conducted by Xu et al in 2018 [21]. They performed bilateral sinus augmentation in 8 adult male rabbits which were divided to control group and experimental group.…”

Section: Resultsmentioning

confidence: 99%

“…Xu et al [21] found new bone growth at 2 weeks on the DHT surface, with osteoblasts on its surface. At 8 weeks - significant increase in density and thickness of new bone was seen.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, osteoid thickness in autoBT group was significantly higher than Bio-Oss ® group [15], a finding which might imply that autoBT is not inferior to Bio-Oss ® in its bone formation capacity. Improved capacity of new bone generation was reported in 2 animal studies among tooth bone graft groups when compared to Bio-Oss ® and β-TCP [19,21], while no difference was found in a porcine study of Lee et al [19] when compared to synthetic hydroxyapatite.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The Use of Tooth Derived Bone Graft Materials in Sinus Augmentation Procedures: a Systematic Review

Shavit¹,

Shavit²,

Pinchasov³

et al. 2019

JOMR

View full text Add to dashboard Cite

Objectives The goal of this systematic review was to assess the current literature about sinus augmentation procedure using different types of tooth derived bone graft materials, thorough analysing the outcomes of sinus grafting with tooth grafts compared to sinus grafting with xenografts, allografts and alloplasts by radiography and histomorphometry. Material and Methods An electronic search in the MEDLINE (NCBI PubMed and PubMed Central) database was conducted to identify articles concerning application of tooth bone grafts in sinus augmentation. The search was restricted to English language articles published in the last 10 years (December 2009 to March 2019). Results In total, 21 articles were found, out of which 7 met the inclusion criteria and were included in the final synthesis. According to the type of diagnostic tool, data about graft material outcome in sinus was extracted, and included the residual alveolar height, augmented graft height, resorption height as seen in panoramic radiography and histomorphometric analysis of new bone formation and residual graft material. Conclusions Within the limitations of our review, we suggest that tooth derived graft materials are as successful as xenografts, allografts and alloplasts in sinus augmentation procedures according to the radiographic and histomorphometric showings. Additional wider research should be conducted in order to determine whether tooth derived graft materials are superior to the currently used materials.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Xu et al [21] found new bone growth at 2 weeks on the DHT surface, with osteoblasts on its surface. At 8 weeks - significant increase in density and thickness of new bone was seen.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Use of Tooth Derived Bone Graft Materials in Sinus Augmentation Procedures: a Systematic Review

Shavit¹,

Shavit²,

Pinchasov³

et al. 2019

JOMR

View full text Add to dashboard Cite

show abstract

“…Mordenfeld et al, performing histologic and histomorphometric analysis of bone harvesting 11 years after sinus floor augmentation with deproteinized bovine and autogenous bone, stated that the xenograft particles were not resorbed but were well-integrated in lamellar bone, with no significant changes in particle size [33]. According to a recent study, evaluating bovine graft absorption after sinus elevation in rabbits, 8 weeks post-surgery, reported that this material is resorbed very slowly, leading to low new bone formation since biodegradation is an important factor for bone regeneration [34]. A relatively conflicting result in studies with bovine bone grafts is the fact that although new bone formation is not the maximum in this type compared to other grafts, total fractions of mineralized tissue (graft and bone) is sometimes found to be higher in relation to other grafts.…”

Section: Discussionmentioning

confidence: 99%

Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs

et al. 2020

View full text Add to dashboard Cite

Regeneration of large jaw bone defects still remains a clinical challenge. To avoid incomplete bone repair, bone grafts have been advocated to support the healing process. This study comparatively evaluated new bone formation among a synthetic graft substitute, a human bone derivative, and a bovine xenograft. Materials were placed in 3 out of the 4 bone cavities, while 1 deficit was left empty, serving as a control, in mono-cortical defects, surgically prepared in the porcine calvaria bone. Animals were randomized in 2 groups and euthanized at 8 and 12 weeks. Harvested tissue specimens were qualitatively evaluated by histology. New bone formation was quantitatively measured by histomorphometry. Maximum new bone formation was noticed in defects grafted with beta-tricalcium phosphate b-TCP compared to the other bone substitutes, at 8 and 12 weeks post-surgery. Bovine and human allograft induced less new bone formation compared to empty bone cavity. Histologic analysis revealed that b-TCP was absorbed and substituted significantly, while bovine and human allograft was maintained almost intact in close proximity with new bone. Based on our findings, higher new bone formation was detected in defects filled with b-TCP when compared to bovine and human graft substitutes.

show abstract

Comparative analysis of lateral maxillary sinus augmentation with a xenogeneic bone substitute material in combination with piezosurgical preparation and bony wall repositioning or rotary instrumentation and membrane coverage: a prospective randomized clinical and histological study

et al. 2022

View full text Add to dashboard Cite

Objectives The present randomized controlled clinical study aimed to investigate if, in lateral maxillary sinus augmentation, the repositioned bony wall or the application of a collagen membrane results in more preferable new hard tissue formation. Materials and methods Forty patients were divided into two study groups. Both groups received a xenogeneic bone substitute material (BSM) during lateral sinus augmentation. In the bony wall group (BW), following piezosurgery, the retrieved bony wall was repositioned. In the collagen membrane group (CM), following rotary instrument preparation, collagen membrane coverage was applied. After 6 months, biopsies were taken to histologically analyze the percentage of BSM, connective tissue (CT), and newly formed bone (NFB) following both approaches. Results Forty implants were placed and 29 harvested biopsies could be evaluated. Duration of surgery, membrane perforations, and VAS were detected. Histomorphometrical analysis revealed comparable amounts of all analyzed parameters in both groups in descending order: CT (BW: 39.2 ± 9%, CM: 37,9 ± 8.5%) > BSM (BW: 32.9 ± 6.3%, CM: 31.8 ± 8.8%) > NB (BW: 27.8 ± 11.2%, CM: 30.3 ± 4.5%). Conclusions The results of the present study show that the closure of the access window by means of the retrieved bony wall or a native collagen membrane led to comparable bone augmentation results. Clinical trial clinicaltrials.gov NCT04811768. Clinical relevance Lateral maxillary sinus augmentation with the application of a xenogeneic BSM in combination with a native collagen membrane for bony window coverage represents a reliable method for surgical reconstruction of the posterior maxilla. Piezosurgery with bony window repositioning delivers comparable outcomes without membrane coverage.

show abstract

Comparative Histomorphometric Analysis of Maxillary Sinus Augmentation With Deproteinized Bovine Bone and Demineralized Particulate Human Tooth Graft

Abstract: Significant higher new bone formation was revealed in the experimental group than in the control group.

Cited by 14 publications

References 39 publications

The Use of Tooth Derived Bone Graft Materials in Sinus Augmentation Procedures: a Systematic Review

The Use of Tooth Derived Bone Graft Materials in Sinus Augmentation Procedures: a Systematic Review

Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs

Comparative analysis of lateral maxillary sinus augmentation with a xenogeneic bone substitute material in combination with piezosurgical preparation and bony wall repositioning or rotary instrumentation and membrane coverage: a prospective randomized clinical and histological study

Contact Info

Product

Resources

About