Comparative Heating Efficiency of Cobalt-, Manganese-, and Nickel-Ferrite Nanoparticles for a Hyperthermia Agent in Biomedicines

Abstract

In this study, the ac magnetic hyperthermia responses of spinel CoFe 2 O 4 , MnFe 2 O 4 , and NiFe 2 O 4 nanoparticles of comparable sizes (∼20 nm) were investigated to evaluate their feasibility of use in magnetic hyperthermia. The heating ability of EDT-coated nanoparticles which were dispersed in two different carrier media, deionized water and ethylene glycol, at concentrations of 1 and 2 mg/mL, was evaluated by estimating the specific loss power (SLP) (which is a measure of magnetic energy transformed into heat) under magnetic fields of 15, 25, and 50 kA/m at a constant frequency of 195 kHz. The maximum value of SLP has been found to be ∼315 W/g for CoFe 2 O 4 and ∼295 W/g for MnFe 2 O 4 and NiFe 2 O 4 nanoparticles. We report very promising heating temperature rising characteristics of CoFe 2 O 4 , MnFe 2 O 4 , and NiFe 2 O 4 nanoparticles under different applied magnetic fields that indicate the effectiveness of these nanoparticles as hyperthermia agents.

Aminodextran Coated CoFe2O4 Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia

“…Figure 7 presents temperature change ΔT per milligram (and per milliliter) of the sample. Equation (3) was used to estimate the SAR values of sample 1 and found to be 0.02 W/g that is in agreement with the reported literature [42,43]. Figure 7b shows the magnetic hyperthermia measured on the dispersion of sample 3.…”

Synthesis, structural, mechanical, and in vitro evaluations of NiFe2O4/ZrO2 composites

“…The magnetic properties infer a gradual upsurge in the magnetization value as a function of NiFe 2 O 4 content in the composite specimen. Ferrimagnetic features of the NiFe 2 O 4 /ZrO 2 composite are apparent; however, the magnetic property of investigated systems is relatively inferior than the reported data . The reason being the presence of ZrO 2 as a secondary component and moreover the relatively enhanced particle size of NiFe 2 O 4 acts as an additional factor to attain moderate magnetic features.…”

Improvements in the Organic-Phase Hydrothermal Synthesis of Monodisperse MxFe3–xO4 (M = Fe, Mg, Zn) Spinel Nanoferrites for Magnetic Fluid Hyperthermia Application

“…This negligible remanence and coercivity can be ascribed to the particle size distributions. 59 The inclusion of Mg 2+ and Zn 2+ ions in the spinel structure of Fe 3 O 4 does not alter its superparamagnetic characteristic which is advantageous for biomedical applications. 60 Looking into the magnetization values, a reduction in magnitude was observed when the ration of surfactants (OA/OAm) increased from 1:4 to 1:5.…”

“…This rapid rise is correlated to Néel relaxation and Brownian rotation of particles under a switching magnetic field. 59 The temperature saturation is due to temperature loss from the magnetic fluid to the environment. 72 The nanoferrites differ both in the initial speed of the temperature rise and the time taken to reach the hyperthermic threshold temperature (43 °C).…”