Aminodextran Coated CoFe2O4 Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia

Abstract

Aminodextran (AMD) coated magnetic cobalt ferrite nanoparticles are synthesized via electrostatic adsorption of aminodextran onto magnetic nanoparticles and their potential theranostic application is evaluated. The uncoated and aminodextran-coated nanoparticles are characterized to determine their hydrodynamic size, morphology, chemical composition, zeta potential and magnetization. The aminodextran containing cobalt ferrite nanoparticles of nanometer size are positively charged in the pH range from 3 to 9 and exhibit saturation magnetization of 50 emu/g. The magnetic resonance imaging (MRI) indicates capability for diagnostics and a reduction in intensity with an increase in nanoparticle amount. The hyperthermia capability of the prepared particles shows their potential to generate suitable local heat for therapeutic purposes. There is a rise of 7 °C and 9 °C at 327 kHz and 981 kHz respectively and specific absorption rates (SAR) of aminodextran-coated nanoparticles are calculated to be 259 W/g and 518 W/g at the given frequencies larger than uncoated nanoparticles (0.02 W/g). The development of novel aminodextran coated magnetic cobalt ferrite nanoparticles has significant potential to enable and improve personalized therapy regimens, targeted cancer therapies and ultimately to overcome the prevalence of nonessential and overdosing of healthy tissues and organs.

Theoretical Study on Specific Loss Power and Heating Temperature in CoFe2O4 Nanoparticles as Possible Candidate for Alternative Cancer Therapy by Superparamagnetic Hyperthemia

“…These are two very important issues to consider in magnetic hyperthermia in addition to increasing the specific loss power, on which the effectiveness of tumor therapy greatly depends. Therefore, cobalt ferrite nanoparticles are currently of particular scientific interest to be applied in magnetic hyperthermia for cancer therapy [5,[57][58][59][60][61][62][63][64][65][66].…”

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

“…Magnetic latex particles were productively prepared through the adsorption of aminodextran (AMD) polymer over oxidized dextran; AMD was synthesized using chemical grafting of hexamethylenediamine. The prepared MNPs demonstrated good capability for in vivo diagnostic applications and confirmed greater T 2 contrast ability in comparison with gadolinium in MRI. , …”

“…The prepared magnetic nanoparticles demonstrated good capability for in vivo diagnostic applications and confirmed greater T2 contrast-ability in comparison with gadolinium in MRI. 108,109 Researchers worldwide have also been working persistently for developing multimodal T1-and T2 contrast agents, accompanied by high sensitivity along with an accurate resolution of MRI imaging based on MNPs. Nitrodopamine-PEG grafted single-core truncated cubic IONPs (ND-PEG-tNCIOs) were developed which were able to generate noticeable dual MRI contrasts in MRI with better transverse and longitudinal relaxivities of 791 ± 38.39 and 32 ± 1.29 mM -1 s -1 , respectively.…”

Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications

“…Magnetic INPs are promising agents for magnetic resonance imaging (MRI) [ 7 , 8 ] and contribute considerably to the development of tissue engineering [ 9 , 10 ]. These INPs are promising agents for magnetic hyperthermia [ 11 , 12 ]. Magnetic separation and biosensors based on INPs simplify laboratory diagnostics [ 13 , 14 , 15 ].…”