Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications

Шабатина, Т. И.; Vernaya, O. I.; Shumilkin, A. S.; Semenov, A. M.; Melnikov, M.Y.

doi:10.3390/ma15103602

Cited by 20 publications

(8 citation statements)

References 154 publications

(146 reference statements)

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“…Recently, numerous studies have suggested that Ag-NPs exhibit significant antimicrobial actions, specifically against bacterial infections [ 45 , 46 , 47 ]. Ag-NPs effectively inhibit a wide spectrum of Gram-positive and Gram-negative bacteria, such as Bacillus cereus , Staphylococcus aureus, Micrococcus luteus , Streptococcus agalactiae, Escherichia coli, Pseudomonas aeruginosa , and others [ 48 ]. Silver NPs have shown their effectiveness against resistant and multidrug-resistant microorganisms ( Table 1 ).…”

Section: Metal Nanoparticles (Nps) As Antibacterial Agents Against Ba...mentioning

confidence: 99%

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

2023

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The appearance and increasing number of microorganisms resistant to the action of antibiotics is one of the global problems of the 21st century. Already, the duration of therapeutic treatment and mortality from infectious diseases caused by pathogenic microorganisms have increased significantly over the last few decades. Nanoscale inorganic materials (metals and metal oxides) with antimicrobial potential are a promising solution to this problem. Here we discuss possible mechanisms of pathogenic microorganisms’ resistance to antibiotics, proposed mechanisms of action of inorganic nanoparticles on bacterial cells, and the possibilities and benefits of their combined use with antibacterial drugs. The prospects of using metal and metal oxide nanoparticles as carriers in targeted delivery systems for antibacterial compositions are also discussed.

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Section: Metal Nanoparticles (Nps) As Antibacterial Agents Against Ba...mentioning

confidence: 99%

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

2023

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“…To further improve imaging sensitivity and efficiency of MRI, various probes that are composed of metals and metal oxides and able to enhance proton relaxation in targeted tissues have been developed, including synthetic magnetic nanoparticles (MNPs) by sophisticated chemical modifications, [ 120,121 ] metalloprotein‐based contrast agents by protein‐metal interactions, [ 122 ] and bacteria and bacterial derivatives‐based probes by both surface decoration and genetic modification. [ 123 ] Due to their excellent biomedical capabilities, including a high proportion of surface atoms, biodegradability, biocompatibility, safety, chemical stability, and rapid response, magnetic iron oxide nanoparticles consisting of maghemite (γ‐Fe 2 O 3 ) or magnetite (Fe 3 O 4 ) have been one of the most common MNPs for MRI, which can be either super paramagnetic or ferromagnetic.…”

Section: Types Of Bacteria‐based Living Probesmentioning

confidence: 99%

Bacteria‐Based Living Probes: Preparation and the Applications in Bioimaging and Diagnosis

Jiang,

Cao,

Liu

et al. 2023

Advanced Science

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Bacteria can colonize a variety of in vivo biointerfaces, particularly the skin, nasal, and oral mucosa, the gastrointestinal tract, and the reproductive tract, but also target specific lesion sites, such as tumor and wound. By virtue of their prominent characteristics in motility, editability, and targeting ability, bacteria carrying imageable agents are widely developed as living probes for bioimaging and diagnosis of different diseases. This review first introduces the strategies used for preparing bacteria‐based living probes, including biological engineering, chemical modification, intracellular loading, and optical manipulation. It then summarizes the recent progress of these living probes for fluorescence imaging, near‐infrared imaging, ultrasonic imaging, photoacoustic imaging, magnetic resonance imaging, and positron emission tomography imaging. The biomedical applications of bacteria‐based living probes are also reviewed particularly in the bioimaging and diagnosis of bacterial infections, cancers, and intestine‐associated diseases. In addition, the advantages and challenges of bacteria‐based living probes are discussed and future perspectives are also proposed. This review provides an updated overview of bacteria‐based living probes, highlighting their great potential as a unique yet versatile platform for developing next‐generation imageable agents for intelligent bioimaging, diagnosis, and even therapy.

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“…Inorganic NPs are made up of inorganic oxides of Si, Ag, Au, Zn, Mg, Mn, Cu, Se, Al, or Ti and hence they differ in shape, size, solubility and stability. Their characteristics are also defined by pH, temperature, reduction time, concentration of the reducing agent, and aggregation behaviour that impact their antimicrobial potency [66,67]. For example, iron oxide NPs (FeONPs) are allied with DNA hybridization technique to heighten the capturing of 16S ribosomal RNA gene of bacteria [68].…”

Section: Nanoscale Antimicrobial Substancesmentioning

confidence: 99%

Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies

et al. 2022

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Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of “post-antibiotic era”. It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly due to the lack of new/next generation of antimicrobials. In this context, nanoscale materials with antimicrobial potential have a great promise to treat deadly pathogens. These functional materials are uniquely positioned to effectively interfere with the bacterial systems and augment biofilm penetration. Most importantly, the core substance, surface chemistry, shape, and size of nanomaterials define their efficacy while avoiding the development of AMR. Here, we review the mechanisms of AMR and emerging applications of nanoscale functional materials as an excellent substitute for conventional antibiotics. We discuss the potential, promises, challenges and prospects of nanobiotics to combat AMR. Graphical Abstract

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Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications

Cited by 20 publications

References 154 publications

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

Bacteria‐Based Living Probes: Preparation and the Applications in Bioimaging and Diagnosis

Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies

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