Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies

Chakraborty, Nayanika; Jha, Diksha; Roy, Indrajit; Kumar, Pradeep; Gaurav, Shailendra Singh; Marimuthu, Kalisvar; Ng, Oon-Tek; Lakshminarayanan, Rajamani; Verma, Navin Kumar; Gautam, Hemant K.

doi:10.1186/s12951-022-01573-9

Cited by 44 publications

(15 citation statements)

References 248 publications

(247 reference statements)

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“…Several promising nanotechnology-based approaches aim to enhance the efficacy of the already available antibiotics as well as identify new ones—overall, with an emphasis on strategies against antimicrobial resistance [ 256 , 271 , 272 ].…”

Section: At the Dawn Of The Post-antibiotic Era?mentioning

confidence: 99%

“…Due to the achievements of nanomedicine, the efficacy of antibiotics can be enhanced by using so-called “antibiotic nanocarriers”. The role of these nanoparticle carriers—which can be divided into inorganic/organic, carbon-based, and hybrid structures [ 272 ]—is to deliver antibiotics directly to their final destinations [ 256 , 271 ] ( Figure 11 (3)). One of the classes of such nanocarriers is liposomes, which resemble nanocapsules and act as lipid-based surface-functionalized delivery systems protecting antibiotics from degradation.…”

Section: At the Dawn Of The Post-antibiotic Era?mentioning

confidence: 99%

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Antibiotics and Bacterial Resistance—A Short Story of an Endless Arms Race

Baran

Kwiatkowska

Potocki

2023

IJMS

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Despite the undisputed development of medicine, antibiotics still serve as first-choice drugs for patients with infectious disorders. The widespread use of antibiotics results from a wide spectrum of their actions encompassing mechanisms responsible for: the inhibition of bacterial cell wall biosynthesis, the disruption of cell membrane integrity, the suppression of nucleic acids and/or proteins synthesis, as well as disturbances of metabolic processes. However, the widespread availability of antibiotics, accompanied by their overprescription, acts as a double-edged sword, since the overuse and/or misuse of antibiotics leads to a growing number of multidrug-resistant microbes. This, in turn, has recently emerged as a global public health challenge facing both clinicians and their patients. In addition to intrinsic resistance, bacteria can acquire resistance to particular antimicrobial agents through the transfer of genetic material conferring resistance. Amongst the most common bacterial resistance strategies are: drug target site changes, increased cell wall permeability to antibiotics, antibiotic inactivation, and efflux pumps. A better understanding of the interplay between the mechanisms of antibiotic actions and bacterial defense strategies against particular antimicrobial agents is crucial for developing new drugs or drug combinations. Herein, we provide a brief overview of the current nanomedicine-based strategies that aim to improve the efficacy of antibiotics.

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Section: At the Dawn Of The Post-antibiotic Era?mentioning

confidence: 99%

Section: At the Dawn Of The Post-antibiotic Era?mentioning

confidence: 99%

Antibiotics and Bacterial Resistance—A Short Story of an Endless Arms Race

Baran

Kwiatkowska

Potocki

2023

IJMS

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“…Other than this, numerous nano-antibiotics, including mupirocin, gentamicin, polymyxin B, fluconazole, and others, are also being used in therapeutic settings. Prevnar is a pneumococcal vaccine created by Wyeth that contains saccharides of seven serotypes of the capsular antigens of Streptococcus pneumoniae coupled to mutant CRM197 diphtheria toxoid (Bricks & Berezin, 2006;Chakraborty et al, 2022). Other than these commercial nanoformulations, there are v a r i o u s o n g o i n g s t u d i e s fo r t h e d e v e l o p m e n t o f nanoformulations having antibacterial and antimicrobial properties.…”

Section: Antibiotic-np Conjugates At the Industrial Level Or In Clini...mentioning

confidence: 99%

“…Nanotoxicity in aquatic ecosystems is a major and recent concern, as increasing amounts of engineered nanoparticles are being used and finding their way into the hydrosphere. Nanoparticles with redox or dissolving properties have the potential to disrupt cellular membrane stability ( Khezerlou et al., 2018 ; Chakraborty et al., 2022 ). If they enter the cell, they cause oxidative damage, so in general, they have a bacteriostatic effect and, in large enough concentrations, bactericidal effects.…”

Section: Econanotoxicitymentioning

confidence: 99%

Nanomaterials to address the genesis of antibiotic resistance in Escherichia coli

Kaushik

Sarkar

Singh

et al. 2023

Front. Cell. Infect. Microbiol.

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Escherichia is a genus of prokaryotic gram-negative bacteria which forms a vital component of the gut microbiota of homeotherms including humans. Many members of this genus are commensals and pathogenic strains, which are responsible for some of the most common bacterial infections and can be fatal, particularly in the case of newborns and children. The fecal matter in wastewater treatment plants serves as major environmental sinks for the accumulation of Escherichia. The rise in antibiotic pollution and the lateral gene exchange of antibiotic-resistant genes have created antibiotic-resistant Escherichia strains that are often called superbugs. Antibiotic resistance has reached a crisis level that nowadays existing antibiotics are no longer effective. One way of tackling this emerging concern is by using nanomaterials. Punitively, nanomaterials can be used by conjugating with antibodies, biomolecules, and peptides to reduce antibiotic usage, whereas, preventatively, they can be used as either nano-antimicrobial additives or nano-photocatalytic sheets to reduce the microbial population and target the superbugs of environmental Escherichia. In this review, we have explored the threat posed by pathogenic Escherichia strains in the environment, especially in the context of antibiotic-resistant strains. Along with this, we have discussed some nanomaterial-mediated strategies in which the problem can be addressed by using nanomaterials as nanophotocatalytics, antimicrobial additives, drugs, and drug conjugates. This review also presents a brief overview of the ecological threats posed by the overuse of nanomaterials which warrants a balanced and judicious approach to the problem.

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“…The nanoparticles can be combined to antimicrobial drugs (antibiotics, antivirals, antifungals). The combination with antibiotic molecules is the most documented, and they are called the nanobiotics [ 196 ]. The MNPs are used for their reduced cost, easy synthesis and use [ 193 ].…”

Section: Nanoparticlesmentioning

confidence: 99%

Alternatives Therapeutic Approaches to Conventional Antibiotics: Advantages, Limitations and Potential Application in Medicine

et al. 2022

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Resistance to antimicrobials and particularly multidrug resistance is one of the greatest challenges in the health system nowadays. The continual increase in the rates of antimicrobial resistance worldwide boosted by the ongoing COVID-19 pandemic poses a major public health threat. Different approaches have been employed to minimize the effect of resistance and control this threat, but the question still lingers as to their safety and efficiency. In this context, new anti-infectious approaches against multidrug resistance are being examined. Use of new antibiotics and their combination with new β-lactamase inhibitors, phage therapy, antimicrobial peptides, nanoparticles, and antisense antimicrobial therapeutics are considered as one such promising approach for overcoming bacterial resistance. In this review, we provide insights into these emerging alternative therapies that are currently being evaluated and which may be developed in the future to break the progression of antimicrobial resistance. We focus on their advantages and limitations and potential application in medicine. We further highlight the importance of the combination therapy approach, wherein two or more therapies are used in combination in order to more effectively combat infectious disease and increasing access to quality healthcare. These advances could give an alternate solution to overcome antimicrobial drug resistance. We eventually hope to provide useful information for clinicians who are seeking solutions to the problems caused by antimicrobial resistance.

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Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies

Cited by 44 publications

References 248 publications

Antibiotics and Bacterial Resistance—A Short Story of an Endless Arms Race

Antibiotics and Bacterial Resistance—A Short Story of an Endless Arms Race

Nanomaterials to address the genesis of antibiotic resistance in Escherichia coli

Alternatives Therapeutic Approaches to Conventional Antibiotics: Advantages, Limitations and Potential Application in Medicine

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