Comparative Evaluation of the Release Properties of Verapamil HCL and Carbamazepine From Microcrystalline Cellulose Ii Pellets

Abstract

Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid for a high and low solubility drugs such as verapamil. HCl and carbamazepine, respectively. Methods:Approximately, 30 g of MCCII and drug mixtures were hydrated, passed through a # 20 mesh sieved and spheronizated at a frequency of 6 Hz and residence time of 480 s. A microscopy analysis was used to evaluate the shape and size descriptors. Pellets properties such as compressibility, friability, density, flowability and product yield were also evaluated. Drug release properties were tested according to the USP specifications and compared to those of MCCI. Results:The wetting level of the excipients depended on drug loading and drug solubility. Thus, a high drug loading (>50%) rendered pellets having a low yield, flowability and caused a detriment on size descriptors. Likewise, the regular morphology and strength of MCCII-based pellets was highly affected by increasing drug loads. Verapamil. HCl pellets were less friable and compressible and showed better flowability than carbamazepine pellets. Regardless of drug loading and drug solubility, MCCII-based pellets released more than 80% of verapamil. HCl within 10 min, whereas released more than 75% of carbamazepine within 15 min. Conversely, MCCI pellets had a satisfactory verapamil. HCl release, but ~30% carbamazepine release within 1h. Conclusion:MCCII proved to be a better excipient than MCCI to yield beads having optimal pellet characteristics, and rendered an immediate release profile for verapamil. HCl and carbamazepine.

Mempelajari Pengaruh Konsentrasi Maltodekstrin dan Polivinil Pirolidon (PVP) terhadap Karakteristik Sifat Fisik Tablet Effervescent Kopi Robusta (Coffea robusta Lindl)

“…Jumlah bahan pengikat yang ditambahkan dalam formula tablet dapat mempengaruhi karakteristik tablet. Jika digunakan dalam jumlah berlebihan maka akan membuat tablet menjadi keras dan akan menurunkan waktu hancur dari tablet (Rojas & Kumar, 2012).…”

“…Akibatnya waktu larut tablet menjadi lama. Maltodekstrin akan membantu kelarutan karena mudah larut dalam air, dengan adanya maltodekstrin tablet akan menjadi lebih rapuh sehingga air lebih mudah berpenetrasi ke dalam tablet melalui poripori tablet yang longgar sehingga waktu larutnya lebih cepat (Rojas & Kumar, 2012).…”

Formulation and Investigation of Polymeric Multiple Unit Pellet Systems Consisting of Sustained Release Glimepiride and Immediate Release Atorvastatin Calcium

“…The angle of repose is the most widely used method to check the flowability of pellets, which is done by measuring the height of the heap [10].…”

“…The photographs were observed for morphological characteristics and to confirm spherical nature of the pellets. SEM was performed using Hitachi and SEM at 5 kV having different magnifications using Hitachi Noran System 7 manufactured by Thermo Fisher Scientific [10].…”

Formulation of Immediate Release (Ir) Atorvastatin Calcium Pellets and Sustained Release (Sr) Glibenclamide for Fixed-Dose Combination Dosage Form

“…Angle of repose was the most widely used technique for measuring the flowability [by determining the shape of the powder heap]. The formula used to measure the flowability [13].…”