Formulation and Investigation of Polymeric Multiple Unit Pellet Systems Consisting of Sustained Release Glimepiride and Immediate Release Atorvastatin Calcium
Abstract:Objective: The objective of the present work was to develop novel fixed-dose combinations (FDCs) for improvement of glucose tolerance in type II diabetes mellitus patients associated with dyslipidemia.
Methods: Multiple unit pellet systems (MUPSs) consisting of sustained release (SR) glimepiride and immediate release atorvastatin calcium pellets were formulated. The SR glimepiride pellets were prepared using a combination of locust bean gum and gum ghatti/guar gum. Similarly, the immediate release of ato… Show more
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