Comparative evaluation of the cortisol level of unstimulated saliva in patients with and without chronic periodontitis

Naghsh, Narges; Mogharehabed, Ahmad; Karami, Elahe; Yaghini, Jaber

doi:10.4103/1735-3327.270786

Cited by 6 publications

(12 citation statements)

References 34 publications

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“…The methodological characteristics of the studies were observed as study design, considering the inclusion and exclusion criteria, and 24 studies were excluded due to the presence of control group with smokers (32), absence of periodontal measures (33,34), and lack of a control group . Therefore, after full-text reading, 11 studies were selected for qualitative analysis (10,(56)(57)(58)(59)(60)(61)(62)(63)(64)(65). Figure 1 describes the flowchart of the studies selection according to the PRISMA protocol.…”

Section: Selected Studiesmentioning

confidence: 99%

“…All selected studies were observational-six were casecontrol (10,56,(59)(60)(61)63), and five were cross-sectional design (57,58,62,64,65). Studies were performed in several countries, including Brazil (10,56,57,59), Italy (62), Austria (58), Jordan (60), China (61), Israel (63), India (64), and Iran (65). The number of participants involved in each study ranged from 46 to 300 patients.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Naghsh et al (65) study diagnosed periodontitis by considering a CAL ≥ 4 mm or PPD of ≥5 mm. The severity of periodontitis was categorized according to the AAP.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Among all these studies, eight showed a significant association between periodontitis and anxiety (56,58,59,(61)(62)(63)(64)(65) and three studies did not show significant results for this association (10,57,60). However, the different types of methods for assessing anxiety made it impossible to carry out a meta-analysis.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Some studies have methodological flaws regarding the lack of description of the selection process of the control group (56) and undefined controls (56,59,60). Additionally, the absence of description of the rate of non-respondents was observed in all studies (10,(56)(57)(58)(59)(60)(61)(62)(63)(64)(65).…”

Section: Risk Of Biasmentioning

confidence: 99%

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Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review

et al. 2021

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Periodontitis is a multifactorial disease triggered by dysbiotic biofilms, involving the host's immune response, systemic and behavioral factors, including psychosocial conditions. This systematic review aimed to investigate the possible association between periodontitis and anxiety in adults. Searches were performed in PubMed, Scopus, Web of Science, Lilacs, Cochrane, and OpenGrey databases, without language restrictions, considering studies in adults (P-Participants), with (E-Exposure) and without periodontitis (C- Comparison) in an outcome of association with anxiety (O-outcome). Methodological quality assessment was carried out using the Newcastle-Ottawa protocol for case-control and cross-sectional studies, followed by an analysis of the level of evidence using the GRADE tool. Metanalysis was not performed due to several differences in methods applied by authors in primary studies. Eleven observational studies were selected according to the inclusion criteria from the total of 6,380 studies retrieved from databases. Eight studies demonstrated higher anxiety levels in subjects with periodontitis, among which only one study presented a high risk of bias. The GRADE tool revealed a low level of evidence for the anxiety outcome measured by the State-Trait Anxiety Inventory (STAI), both for case-control and cross-sectional studies. However, since anxiety may affect the quality of life of many subjects, it reinforces the need for further studies that evaluate this association for more extended periods.Clinical Trial Registration:PROSPERO-CRD42020190445.

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Section: Selected Studiesmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Naghsh et al (65) study diagnosed periodontitis by considering a CAL ≥ 4 mm or PPD of ≥5 mm. The severity of periodontitis was categorized according to the AAP.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Risk Of Biasmentioning

confidence: 99%

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Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review

et al. 2021

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Cortisol levels in the peri‐implant sulcular fluid among patients with and without peri‐implantitis

Alresayes

Al‐Askar

Mokeem

et al. 2021

J of Periodontal Research

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Background and Objective: Cortisol levels remain uninvestigated in peri-implant sulcular fluid (PISF) of patients with and without peri-implantitis. The present investigation investigated levels of cortisol in PISF among controls (individuals without peri-implantitis) and patients with peri-implantitis. Methods:The patient population comprised of participants with and without periimplantitis (groups 1 and 2, respectively). Demographic information and data related to implant characteristics was recorded. Peri-implant radiographic (crestal bone loss [CBL]) and clinical (modified plaque and bleeding on probing indices [PI and BOP], and probing depth [PD]) and parameters were assessed. In all patients, levels of cortisol were measured in the PISF, which was collected using standard methods. Data normality and group comparisons were assessed, and multiple logistic regression was performed. Probability values less than 0.01 were nominated as being significant.Results: Eighty-eight individuals (44 and 44 in groups 1 and 2, correspondingly) were included. In group 1, 24 and 20 participants were males and females, and there were 22 and 22 males and females in group 2. Mean ages were analogous in both groups.Peri-implant BOP (p < .001); CBL (p < .001); PI (p < .001); and PD (p < .001) were higher among patients in group 1 compared with group 2. The volume of PISF (p < .001) collected and its concentrations of cortisol (p < .001) were significantly higher among patients in group 1 compared with group 2. Regression analysis showed that CBL and PD directly correlated with increased PISF levels of cortisol among participants with peri-implantitis. Conclusion:Within the limits of the present study, it remains debatable whether or not PISF cortisol levels vary among patients with and without peri-implantitis. Further studies are needed to evaluate the role of PISF levels of cortisol in the diagnosis of peri-implantitis.

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Effect of photobiomodulation after non‐surgical mechanical debridement on cortisol levels in the peri‐implant sulcular fluid among patients with peri‐implant mucositis

Alhumaidan

Alali

Ahmed

et al. 2022

Photoderm Photoimm Photomed

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Objective: The aim of this was to compare the efficacy of photobiomodulation after non-surgical mechanical debridement (MD) on cortisol levels (CL) in peri-implant sulcular fluid (PISF) among patients with peri-implant mucositis.Methods: Patients with peri-implant mucositis were encompassed. All patients underwent non-surgical MD with (test group) and without (control group) a single application of photobiomodulation. Demographic data were collected and PISF was collected.Peri-implant modified plaque index (mPI), modified gingival index (mGI), probing depth and crestal bone loss were measured, and CL in PISF were recorded. All clinical parameters and PISF CL were re-assessed at 4 months of follow-up. p < .05 showed statistical significance.Results: Seventeen (14 males and 3 females) and 17 (15 males and 2 females) patients with peri-implant mucositis were recruited in test and control groups. The mean age of patients in the test and control groups was 46.1 ± 6.5 and 50.2 ± 2.7 years respectively. At baseline, mPI, mGI, PD and PISF volume and CL in control and test groups were similar. At follow-up, there was a significant reduction in mPI (p < .001), mGI (p < .001), PD (p < .001) and PISF volume (p < .001) and CL (p < .001) in both groups compared with baseline. There was no difference in mPI, mGI, PD and PISF volume and CL in test and control groups at follow-up. Conclusion:In short term, non-surgical MD with photobiomodulation does not offer additional benefits in terms of reducing soft-tissue inflammatory parameters and PISF CL in patients with peri-implant mucositis.

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Comparative evaluation of the cortisol level of unstimulated saliva in patients with and without chronic periodontitis

Cited by 6 publications

References 34 publications

Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review

Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review

Cortisol levels in the peri‐implant sulcular fluid among patients with and without peri‐implantitis

Effect of photobiomodulation after non‐surgical mechanical debridement on cortisol levels in the peri‐implant sulcular fluid among patients with peri‐implant mucositis

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