Comparative evaluation of soy polysaccharide as direct compression excipient

Malamataris, S.; Goidas, P.; Avgoustakis, Konstantinos

doi:10.3109/03639049209040860

Cited by 3 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, excessive amount of moisture was detrimental to the tablet tensile strength as seen from the reduced tabletability index, b value, and σ 0 of the starch samples equilibrated to 75% RH despite the lowered yield pressure. The subsequent reduction in tablet tensile strength occurring at higher RH has also been reported in other studies (56)(57)(58). It has been suggested that balance between the amount of monolayer moisture, externally adsorbed moisture, and internally absorbed moisture influences tablet tensile strength (1).…”

Section: Amylose-amylopectin Ratio Of Starch and Tableting Propertiessupporting

confidence: 72%

Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets

2022

View full text Add to dashboard Cite

The two main components of starch — amylose and amylopectin, are responsible for its interaction with moisture. This study investigated how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. The starch samples were equilibrated to 33, 53, and 75% relative humidity (RH) and then assessed for tabletability, compactibility, and yield pressure. Effect of humidity on viscoelastic recovery was also evaluated. Tabletability and compactibility of high-amylose starch were better than that of high-amylopectin starch at 33 and 53% RH. However, at 75% RH, the reverse was observed. In terms of yield pressure, high-amylose starch had lower yield pressure than high-amylopectin starch. High-amylose starch tablets also exhibited lower extent of viscoelastic recovery than high-amylopectin starch tablets. The variations in the tableting properties were found to be related to relative locality of the sorbed moisture. Degradation of acetylsalicylic acid in high-amylose starch tablets at 75% RH, 40°C was less than the tablets with high-amylopectin starch. This observation could be attributed to the greater amount of water molecules binding sites in high-amylose starch. Furthermore, most of the sorbed moisture of high-amylose starch was internally absorbed moisture, therefore limiting the availability of diffusible sorbed moisture for degradation reaction. Findings from this study could provide better insights on the influence of amylose-amylopectin ratio on tableting properties and stability of moisture-sensitive drugs. This is of particular importance as starch is a common excipient in solid dosage forms.

show abstract

Section: Amylose-amylopectin Ratio Of Starch and Tableting Propertiessupporting

confidence: 72%

Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets

2022

View full text Add to dashboard Cite

show abstract

The Effect of Humidity on Samples of Microcrystalline Cellulose Taken From the Extrusion/Marumerization Process

Mayville¹,

Atassi²,

Wigent³

et al. 1999

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

The purpose of this work was to examine the sorption and desorption of water by various samples of microcrystalline cellulose, MCC (Avicel PH-101), taken from the extrusion/marumerization process, and to provide data that may explain how water affects the MCC polymer matrix during the formation of beads. Two isopiestic (humidity) studies were conducted: the first used samples exposed directly to controlled humidity conditions, whereas the second used samples that were freeze-dried before being exposed to controlled humidity conditions. Water sorption and desorption were determined gravimetrically. When both sets of samples were initially exposed to low-humidity conditions, they reached equilibrium by desorbing water. When these samples were initially exposed to high-humidity conditions, the high moisture content samples desorbed water, whereas the low moisture content and the freeze-dried samples sorbed water to reach equilibrium. When the first set of samples was initially exposed to high- and then to low-humidity conditions, they reached the same water content achieved by being equilibrated directly at the low-humidity condition. However, samples that were initially exposed to low- and then to high-humidity conditions had equilibrium water contents that were lower than those achieved by being equilibrated directly at the high-humidity condition. The original MCC systems exhibit a hysteretic effect above 85%, whereas the freeze-dried systems have a broader range hysteretic effect starting at 20% relative humidity. The results suggest that the internal structure of the MCC polymer fibers must change with the sorption and desorption of water, supporting the autohesion theory.

show abstract