Evaluation of the Disintegration Action of Soy Polysaccharide by Image Analysis

Amayreh, Rana; Bisharat, Lorina; Cespi, Marco; Palimieri, Giovanni Filippo; Berardi, Alberto

doi:10.1208/s12249-019-1477-x

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…On the contrary, zein, which has poor tabletability [13], is not likely to undergo significant plastic deformation, and thus, swells in all directions. A similar correlation between compaction properties and mechanism of tablets expansion has also been found in immediate-release tablets containing swelling disintegrants [23,25].…”

Section: Resultssupporting

confidence: 63%

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Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix Performance by the Addition of Co-Excipients

et al. 2019

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Zein is an insoluble, yet swellable, biopolymer that has been extensively studied for its applications in drug delivery. Here, we screened the effect of co-excipients on the swelling and drug release of zein tablets. All throughout the study the behavior of zein was benchmarked against that of hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC). Tablets containing either zein, HPMC, or EC alone or in combination with co-excipients, namely lactose, dicalcium phosphate (DCP), microcrystalline cellulose (MCC), polyvinylpyrrolidone (PVP), or sodium lauryl sulfate (SLS) were prepared by direct compression. Matrix swelling was studied by taking continuous pictures of the tablets over 20 h, using a USB microscope connected to a PC. The overall size change and the axial and radial expansion of the tablets were automatically extrapolated from the pictures by image analysis. Moreover, drug release from tablets containing ternary mixtures of zein, co-excipients and 10% propranolol HCl was also studied. Results showed that zein matrices swelled rapidly at first, but then a plateau was reached, resulting in an initial rapid drug burst followed by slow drug release. HPMC tablets swelled to a greater extent and more gradually, providing a more constant drug release rate. EC did not practically swell, giving a nearly constant drug release pattern. Among the additives studied, only MCC increased the swelling of zein up to nearly three-fold, and thus suppressed drug burst from zein matrices and provided a nearly constant drug release over the test duration. Overall, the incorporation of co-excipients influenced the swelling behavior of zein to a greater extent compared to that of HPMC and EC, indicating that the molecular interactions of zein and additives are clearly more complex and distinct.

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Section: Resultssupporting

confidence: 63%

“…The volumetric swelling of tablets was measured by taking pictures of the tablets using a USB-microscope and analyzing the collected images with an image analysis software. A technique previously developed to study the disintegration of immediate-release tablets was adapted here to study tablet swelling [23,24,25].…”

Section: Methodsmentioning

confidence: 99%

Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix Performance by the Addition of Co-Excipients

et al. 2019

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“…Not only did formulation factors have an influence, the effects of crospovidone are also governed by the manufacturing process [53][54][55]. Compression pressure is reported as an important parameter for consideration [56,57]. To the best of our knowledge, the usage of crospovidone in SLS printing has not been reported previously in the literature.…”

Section: Effect Of Crospovidone On Drug Releasementioning

confidence: 97%

Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model

et al. 2021

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Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy density (ED) and formulation factors on the printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors, ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR results revealed that there was no interaction between irbesartan and the applied excipients. DSC results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a significant influence on tablets’ physical, mechanical, and morphological characteristics. Adding lactose monohydrate enabled faster drug release while reducing the possibility for printing with different laser speeds. However, formulations with crospovidone were printable with a wider range of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however, it needs to be governed by the composition of the whole formulation.

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“…Several methodologies have been developed to collect kinetic, topographic, and mechanistic data of tablets in static fluid environments. The most common method of acquiring this data involves a tablet laying in a petri dish or steel mesh within a clear vessel of liquid with a camera and various lens add-ons positioned to view the tablet from the side or above (Amayreh et al, 2019;Desai et al, 2013;Nep et al, 2017;Roberts et al, 2007). Other experiments have used optical cameras in addition to MRI, microscopy, and x-ray microcomputed tomography (XRCT) to visualize tablets in solution (Berardi et al, 2018;Desai et al, 2012;Ma et al, 2020).…”

mentioning

confidence: 99%

“…Tablet diameter in the radial and axial dimensions were recorded as they changed with time via the various imaging technology. Plotting changes to the aspect ratio, the ratio between expansion in radial and axial dimensions, along with changes in time, allowed for the generation of tablet morphology curves (Amayreh et al, 2019;Berardi et al, 2018;Ma et al, 2020). In this way, swelling and expansion behavior of tablets due to disintegration could be analyzed and the effects of specific excipients on this behavior could be characterized.…”

mentioning

confidence: 99%