2022
DOI: 10.1208/s12249-022-02266-0
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Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets

Abstract: The two main components of starch — amylose and amylopectin, are responsible for its interaction with moisture. This study investigated how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. The starch samples were equilibrated to 33, 53, and 75% relative humidity (RH) and then assessed for tabletability, compactibility, and yield pressure. Effect of humidity on viscoelastic recovery was also evaluated. Tabletability and co… Show more

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Cited by 3 publications
(2 citation statements)
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References 59 publications
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“…A measure of the degree of interaction between the polymeric chains of the amorphous and crystalline starch fractions is the swelling capacity of starch (Ogunmolasuyi et al, 2016). The ratio of amylose to amylopectin affects how strong this interaction is (Veronica et al, 2022). Since swelling primarily occurs in the amorphous region, it is directly related to the amount of amylopectin present (Vamadevan & Bertoft, 2020) and is reliant on the ability of starch molecules to bind water.…”
Section: Results and Discusionsmentioning
confidence: 99%
“…A measure of the degree of interaction between the polymeric chains of the amorphous and crystalline starch fractions is the swelling capacity of starch (Ogunmolasuyi et al, 2016). The ratio of amylose to amylopectin affects how strong this interaction is (Veronica et al, 2022). Since swelling primarily occurs in the amorphous region, it is directly related to the amount of amylopectin present (Vamadevan & Bertoft, 2020) and is reliant on the ability of starch molecules to bind water.…”
Section: Results and Discusionsmentioning
confidence: 99%
“…In this study, both temperature at 40 °C and relative humidity of 75% were set up to carry out the accelerated rancidity process for obtaining the rancid ZSS samples from normal ZSS samples over 6 months of storage time. It is worth noting that these storage conditions were not set at random, but were determined according to the parameters of the accelerated test and the drug stability investigation test, which could reflect the change process of substances and the stability of related physicochemical indicators [ 70 , 71 , 72 ]. In recent years, the condition of 40 °C and 75%RH was often used to evaluate the related changes and mechanisms during the storage of TCMs, foods, functional beverages [ 73 ], and cosmetics [ 74 ], such as pecan [ 75 ], Benjakul [ 76 ], Salvia miltiorrhiza [ 77 ], and Piper lhotzkyanum Kunth leaves [ 78 ].…”
Section: Discussionmentioning
confidence: 99%