Comparative evaluation of single or combined anticoccidials on performance, antioxidant status, immune response, and intestinal architecture of broiler chickens challenged with mixed Eimeria species

Abdelhady, A. Y.M.; El-Safty, S. A.; Hashim, Mosaad; Ibrahim, Marwa A.; Mohammed, Faten F.; Elbaz, Ahmed M.; Abdel-Moneim, Abdel-Moneim Eid

doi:10.1016/j.psj.2021.101162

Cited by 17 publications

(12 citation statements)

References 44 publications

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“…The results were mutually verified with clinical data (cecal lesion scores and OPG) and histopathological changes. Study have shown that the infection of Eimeria is closely related to the change of REDOX state of the organism ( Abdelhady et al, 2021 ).Research also showed that antioxidant therapy had potential benefits in treating coccidial infections ( Naidoo et al, 2008 ). In this work, both antioxidant Ellagic acid ( Kilic et al, 2014 ) and Punicalagin ( Aguilar-Zarate et al, 2017 ) showed resistance to coccidiosis infection, and the data of antioxidant indexes were mutually confirmed with all the experimental results above.…”

Section: Discussionmentioning

confidence: 99%

Punicalagin: a monomer with anti-Eimeria tenella effect from fruit peel of Punica granatum L.

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Punicalagin: a monomer with anti-Eimeria tenella effect from fruit peel of Punica granatum L.

et al. 2022

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“…[31] It also induces ROS overproduction manifested by decreased GSH, catalase, and glutathione peroxidase activities in neurons. [32] T A B L E 3 Semiquantitative multiparametric brain lesion scoring in different groups dysfunction, increased intracellular Na and Ca levels, and finally activated lysosomal and other enzymes leading to cell death. [33] Regarding the apoptotic and antiapoptotic markers, our study uncovered that PEN upregulated the mRNA levels of bax, caspase 3, caspase 9, and downregulated the bcl-2 gene in brain tissue homogenates.…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

The ameliorative effect ofN‐acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats

Morgan

Hassanen

Ogaly

et al. 2021

J Biochem & Molecular Tox

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Penconazole (PEN) is a widely used systemic fungicide to treat various fungal diseases in plants but it leaves residues in crops and food products causing serious environmental and health problems. N-acetylcysteine (NAC) is a precursor of the antioxidant glutathione in the body and exerts prominent antioxidant and antiinflammatory effects. The present study aimed to explore the mechanistic way of NAC to ameliorate the PEN neurotoxicity in male rats. Twenty-eight male rats were randomly divided into four groups (n = 7) and given the treated material via oral gavage for 10 days as the following: Group I (distilled water), Group II (50 mg/kg body weight [bwt] PEN), Group III (200 mg/kg bwt NAC), and Group IV (NAC + PEN).After 10 days all rats were subjected to behavioral assessment and then euthanized to collect brain tissues to perform oxidative stress, molecular studies, and pathological examination. Our results revealed that PEN exhibits neurobehavioral toxicity manifested by alteration in the forced swim test, elevated plus maze test, and Y-maze test. There were marked elevations in malondialdehyde levels with reduction in total antioxidant capacity levels, upregulation of messenger RNA levels of bax, caspase 3, and caspase 9 genes with downregulation of bcl2 genes. In addition, brain sections showed marked histopathological alteration in the cerebrum and cerebellum with strong bax and inducible nitric oxide synthetase protein expression. On the contrary, cotreatment of rats with NAC had the ability to improve all the abovementioned neurotoxic parameters. The present study can conclude that NAC has a neuroprotective effect against PEN-induced neurotoxicity via its antioxidant, anti-inflammatory, and antiapoptotic effect. We recommend using NAC as a preventive and therapeutic agent for a wide variety of neurodegenerative and neuroinflammatory disorders.

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“…Foodborne diseases have increased worldwide, with a noticeable public health concern ( Abd El-Hack et al, 2021 , Abd El-Hack et al, 2020c ). Besides, the development and outbreaks of antibiotic-resistance microbes threaten human and animal health and cause a global health crisis ( Abdelhady et al, 2021 , Nour et al, 2021 ). Additionally, the antioxidant defenses in biological systems are not fully able to counter oxidative stress due to the wide variety of stressors and free radical inducers ( El-Tarabily et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial activities of Spirulina platensis extracts and biogenic selenium nanoparticles against selected pathogenic bacteria and fungi

Abdel-Moneim

El‐Saadony

Shehata

et al. 2022

Saudi Journal of Biological Sciences

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128

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Comparative evaluation of single or combined anticoccidials on performance, antioxidant status, immune response, and intestinal architecture of broiler chickens challenged with mixed Eimeria species

Cited by 17 publications

References 44 publications

Punicalagin: a monomer with anti-Eimeria tenella effect from fruit peel of Punica granatum L.

Punicalagin: a monomer with anti-Eimeria tenella effect from fruit peel of Punica granatum L.

The ameliorative effect ofN‐acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats

Antioxidant and antimicrobial activities of Spirulina platensis extracts and biogenic selenium nanoparticles against selected pathogenic bacteria and fungi

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