Punicalagin: a monomer with anti-Eimeria tenella effect from fruit peel of Punica granatum L.

Yang, Yunqiao; Ding, Xieying; Memon, Fareed Uddin; Zhang, Geyin; Jiang, Meihui; Hu, Dandan; Si, Hongbin

doi:10.1016/j.psj.2022.102100

Cited by 9 publications

(9 citation statements)

References 43 publications

(45 reference statements)

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“…Our research showed that P. granatum has dose-dependent in vitro anticoccidial effect on oocyst sporulation, which is due to a variety of bioactive phytochemical constituents. According to the most recent research, PGY has 100% sporulation inhibition as well as 48.60% for PGE at 72 and 96 h. These results are consistent with earlier studies that found punicalagin to be an effective anticoccidial monomer in P. granatum (Al-Shaibani et al, 2020;Amer et al, 2015;Berto et al, 2014;Dkhil, 2013;Khorrami et al, 2022;Yang et al, 2022) and may be attributable to the fruit harvested in Yemen having higher quantities of polyphenolic compounds.…”

Section: Discussionsupporting

confidence: 85%

In vitro studies for antiparasitic activities of Punica granatum extract

Al‐Shaebi,

Al‐Quraishy,

Maodaa

et al. 2023

Microscopy Res & Technique

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Because of the drug resistance, medicinal plants are used more frequently than coccidiostats to treat and control coccidiosis. Punica granatum is a powerful antioxidant with a variety of medicinal uses. This study used an in vitro experiment to investigate how different P. granatum from Yemen (Y) and Egypt (E) sources affected oocyst sporulation and served as an anthelminthic effector. In contrast to PGE and mebendazole, PGY (200 mg/mL) has the shortest time to paralyze and death the earthworm Eisenia fetida in this investigation. In addition, the treated worm groups' cuticle thickness and shrinkage in comparison to the control group were assessed and contrasted. Eimeria papillata is used as a model protozoan parasite in anticoccidial assays. This study shows that P. granatum affects oocysts sporulation in a dose‐dependent manner, with maximal percentages of 100% (PGY) and 48.60% (PGE) at 96 h for P. granatum concentrations of 200 mg/mL. Inhibition (%) was compared to various detergents, as well as positive and negative controls. According to our research, the P. granatum extract had powerful anthelmintic and anticoccidial properties, with the potency changing according to the environmental conditions of each fruit source.Research Highlights Habitat of the plant is useful for production and accumulation of some secondary metabolites in plants which be effective for the therapeutic uses. Different parameters in the environmental ecosystem affecting variation in chemical compositions and biological activity of P. granatum.

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Section: Discussionsupporting

confidence: 85%

In vitro studies for antiparasitic activities of Punica granatum extract

Al‐Shaebi,

Al‐Quraishy,

Maodaa

et al. 2023

Microscopy Res & Technique

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“…This study aimed to evaluate the anthelmintic and anticoccidial activities of P. americana. Previous studies reported the effective role of other fruit extracts like Puniga granotum (Amer et al, 2015;Khorrami et al, 2022;Yang et al, 2022), Citrus x paradise (Pérez-Fonseca et al, 2016), Tribulus terrestris (Hong et al, 2018), Ananas comosus (Daiba et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Biological activities of Persea americana: in vitro and in vivo studies

et al. 2023

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Natural resources emerge as an essential and alternative tool for controlling parasitic agents. The present study was carried out to evaluate in vitro and in vivo effect of Persea americana fruit extract (PAFE) on helminthiasis and coccidiosis. In vitro, anthelmintic activity was performed using PAFE against Allolobophora caliginose. PAFE elicited significant anthelmintic activity comparable to mebendazole with the lesser time taken to paralysis and death for 200 mg/mL. In vitro anticoccidial activity of PAFE, amprolium, phenol, Dettol TM , and formalin were studied after incubation with unsporulated oocysts. PAFE was able to significantly inhibit oocyst sporulation in a dose-dependent manner. A total 35 male mice were divided into seven groups. At day 0, all groups except first and second groups were infected with 1×10 3 E. papillata. Group 1 served as control. Group 2 served as uninfected-treated one. Group 3 was considered an infected-untreated group. After 60 min of infection, groups 4, 5, and 6 were treated with PAFE. Group 7 was treated with amprolium. However, not at par with amprolium, PAFE showed a good anticoccidial activity adjudged based on a significant change in body weight gain, feed intake, oocysts output, and content of carbohydrates and protein. Therefore, PAFE exhibits powerful anthelmintic and anticoccidial effects.

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“…Several studies have been performed to evaluate a beneficial effect of and selected medicinal plants polyphenols against bacterial agents associated with bovine mastitis or Eimeria infection in chickens ( Raheema, 2016 , Amber et al, 2017 , Freitas et al, 2019 , Khorrami et al, 2022 , Yang et al, 2022 , Matsumoto et al, 2015 ). Pomegranate peel represents an important therapeutic potential, not only for human health but also for animals.…”

Section: Antioxidant and Therapeutic Effects Of Pomegranate Peel Extractmentioning

confidence: 99%