Comparative Evaluation of C-Reactive Protein and WBC Count in Fascial Space Infections of Odontogenic Origin

Bagul, Ravikiran; Chandan, Sanjay; Sane, Vikrant Dilip; Patil, Sujay; Yadav, Dinesh Kumar

doi:10.1007/s12663-016-0953-z

Cited by 24 publications

(23 citation statements)

References 16 publications

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“…CRP, WBC count and body temperature correlated with the clinical improvement, and their decrease toward the reference range signifies the resolution of infection. The results of the present study are further supported by Bali et al [19] and Bagul et al [20] who in their respective studies concluded that CRP and WBC count acted as good guide for determining the severity of infection in patients with fascial space infections of odontogenic origin.…”

Section: Discussionsupporting

confidence: 86%

Correlation Between Clinical Course and Biochemical Analysis in Odontogenic Space Infections

Kaur¹,

Sandhu²,

Kaur³

et al. 2018

J. Maxillofac. Oral Surg.

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Objective To correlate the clinical course and biochemical analysis in odontogenic space infections. Methods A randomized prospective study was undertaken in 50 patients presenting with infections of odontogenic origin. The data were subjected to statistical analysis to corelate the values of CRP, WBC count and ESR with the clinical course of odontogenic infections. The statistical analysis was carried out using SPSS Version 17.0 clinical parameters included pain, swelling, mouth opening, dyspnea, dysphagia, hoarseness, body temperature, active discharge, length of hospital stay and number of fascial spaces involved. Results There was a significant correlation between all the clinical parameters and biochemical markers preoperatively as well as on various postoperative days. Conclusion According to the percentage rate of fall, CRP was considered as the best indicator of clinical course/ recovery of the patient, followed by WBC count and ESR, respectively.

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Section: Discussionsupporting

confidence: 86%

Correlation Between Clinical Course and Biochemical Analysis in Odontogenic Space Infections

Kaur¹,

Sandhu²,

Kaur³

et al. 2018

J. Maxillofac. Oral Surg.

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“…9,11,28 In this study, 66.67% of patients did not have comorbid or signs of dehydration. This is not in accordance with the research conducted by Bagul et al 26 in 2016 which stated that odontogenic infections generally have comorbid predisposing factors, for example: diabetes mellitus, obesity, immunosuppression or arterial hypertension which have systemic consequences. 25 In addition to comorbid factors, Bagul et al 26 also explained that the severity of odontogenic infections could be due to other factors such as advanced adulthood, tobacco smoking habits, drug abuse, poverty and patients with poor social conditions which can also cause a decline in the immune system.…”

Section: Discussioncontrasting

confidence: 86%

“…The condition of trismus and dysphagia is a clinical parameter that can detect signs of respiratory tract obstruction. 26,27 From the results of clinical examination to see involvement of facial space, it was found 63.33% of patients who had involvement of more than one facial space, and 80% of them suffered infections in the submandibular space, which consistent with research conducted by Opitz et al 25 and Heim et al 20 explaining that mandibular molar teeth are the most common focus of infection in odontogenic infections because their root tips reach the mylohyoid muscle so that without proper management of the periapical infections can spread to the submandibular space or parapharyngeal space. 28,29 The involvement of more than one space can occur due to the delay of the patient in seeking appropriate treatment for odontogenic infections.…”

Section: Discussionmentioning

confidence: 99%

Correlation of odontogenic infection severity score with C-reactive protein levels on patients with odontogenic infection in Dr Hasan Sadikin General Hospital Bandung

et al. 2021

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Introduction: Head and neck infections commonly caused by spreading odontogenic infection, which able to cause a local and systemic manifestation, from mild to severe complications according to its severity. Assessment of the severity of odontogenic infections is essential to determine the prognosis, assessed through local and systemic parameters. Laboratory examination used to examine the biological marker that indicates the ongoing infection. C-reactive protein (CRP) is a protein synthesised by hepatocytes in response to the body's inflammatory process, including odontogenic infection. This study was aimed to analyse the severity score of odontogenic infections using the CRP levels in patients with odontogenic infections. Methods: An analytic study with a cross-sectional approach was conducted on 30 patients of Dr Hasan Sadikin General Hospital Bandung diagnosed with odontogenic infections, determined by calculations according to Hosmer and Lemeshow. Assessment of the severity score in odontogenic infections and quantitative CRP levels with the Dimension tool was conducted afterwards. Correlation between odontogenic infection severity score and CRP levels was analysed using regression and correlation tests. Results: From 30 subjects, there was found 33.3% with mild severity score, 63.3% moderate score and 3.3% severe score. The mean of the CRP level was significantly increased according to the odontogenic severity scoring category. All research subjects who were examined showed that there was a very strong and significant correlation (p-value<0.05) between the severity of odontogenic infections and CRP levels in odontogenic infection patients with a correlation coefficient r=0.84 (p=0.001). Conclusion: There is a positive correlation between the CRP levels and the severity score of odontogenic infection. The higher the CRP levels, the odontogenic infection will be more severe. Therefore, the CRP level might be considered an additional biomarker in supporting the severity of odontogenic infection in clinical practice.

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“…The high WBC counts in the SCD population could be as a result from infections or reactions to medications. 22 , 23 Evaluation of WBCs should be performed periodically in primary health care clinics to identify patients with lower or higher values than the normal WBC range. This may enable hematologists to assess the current medications, underlying etiology, or impending SCD crisis and initiate treatment to mitigate symptoms and modifiable factors that are associated with high WBCs.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of abnormal leukocyte count, and its predisposing factors, in patients with sickle cell disease in Saudi Arabia

Ahmed

Ali

Alsuliman

et al. 2017

JBM

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IntroductionHigh white blood cell (WBC) count is an indicator of sickle cell disease (SCD) severity, however, there are limited studies on WBC counts in Saudi Arabian patients with SCD. The aim of this study was to estimate the prevalence of abnormal leukocyte count (either low or high) and identify factors associated with high WBC counts in a sample of Saudi patients with SCD.MethodsA cross-sectional and retrospective chart review study was carried out on 290 SCD patients who were routinely treated at King Fahad Hospital in Hofuf, Saudi Arabia. An interview was conducted to assess clinical presentations, and we reviewed patient charts to collect data on blood test parameters for the previous 6 months.ResultsAlmost half (131 [45.2%]) of the sample had abnormal leukocyte counts: low WBC counts 15 (5.2%) and high 116 (40%). High WBC counts were associated with shortness of breath (P=0.022), tiredness (P=0.039), swelling in hands/feet (P=0.020), and back pain (P=0.007). The mean hemoglobin was higher in patients with normal WBC counts (P=0.024), while the mean hemoglobin S was high in patients with high WBC counts (P=0.003). After adjustment for potential confounders, predictors of high WBC counts were male gender (adjusted odds ratio [aOR]=3.63) and patients with cough (aOR=2.18), low hemoglobin (aOR=0.76), and low heart rate (aOR=0.97).ConclusionAbnormal leukocyte count was common: approximately five in ten Saudi SCD patients assessed in this sample. Male gender, cough, low hemoglobin, and low heart rate were associated with high WBC count. Strategies targeting high WBC count could prevent disease complication and thus could be beneficial for SCD patients.

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Comparative Evaluation of C-Reactive Protein and WBC Count in Fascial Space Infections of Odontogenic Origin

Cited by 24 publications

References 16 publications

Correlation Between Clinical Course and Biochemical Analysis in Odontogenic Space Infections

Correlation Between Clinical Course and Biochemical Analysis in Odontogenic Space Infections

Correlation of odontogenic infection severity score with C-reactive protein levels on patients with odontogenic infection in Dr Hasan Sadikin General Hospital Bandung

The prevalence of abnormal leukocyte count, and its predisposing factors, in patients with sickle cell disease in Saudi Arabia

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