Comparative Evaluation of Antidiabetic and Antioxidant Potency of Different Extracts Obtained From Memecylon Species

Abstract

Objective: Memecylon species is being extensively used in traditional medicine for the treatment of skin disorders and it is proved to possess antidiabetic and anti-inflammatory properties. The present investigation was to study the effect of different solvent extracts of five Memecylon species such as M. umbellatum, M. talbotianum, M. edule, M. malabaricum and M. wightii on antidiabetic and antioxidant effects.Methods: Plant extracts were prepared using soxhlet apparatus using different solvents such as hexane, ethyl acetate, methanol and water and obtained extracts were subjected to antidiabetic (α-amylase and α-glucosidase inhibition assays) and antioxidant (2, 2-Diphenyl-2-Picryl Hydrazyl hydrate (DPPH), 2,2-Azino-bis (3-ethyl benzothiazoline-6-Sulfonic acid)diammonium salt (ABTS), Superoxide radical scavenging assay (SRSA) and reducing power assays) evaluated at different doses. Results:Methanol extracts of all five Memecylon species exhibited effective antidiabetic and antioxidant properties among them methanol extracts of M. malabaricum and M. talbotianum have highest biological activity. For α-amylase IC50 value for both M. malabaricum and M. talbotianum was found to be 100 and 130 µg/reaction and IC50 value for α-glucosidase was found to be 6.1 and 7.8 µg/reaction respectively. For DPPH the IC50 Conclusion:The results indicate that methanol extracts of M. malabaricum and M. talbotianum possess potent in vitro antidiabetic and antioxidant activities compared to other Memecylon species. value was found to be 190 µg/reaction, for ABTS 31-39 µg/reaction, for SRSA 950-1200 µg/reaction and for reducing power assay 420-490 µg/reaction respectively.

Antidiabetic Effects of Pumpkin (Cucurbita Moschata Durch) Flesh and Seeds Extracts in Streptozotocin Induced Mice

“…The possible mechanism by which pumpkin brings out its antidiabetic action maybe potentiating and stimulate the insulin secretion from pancreatic β-cells [21]. Another possibility is because the flavonoids can protect the DNA from the oxidative damage, so it can resist the problem in β-cell [22][23][24].…”

Phytochemical Screening and Antidiabetic Activity of Different Leaf Extracts From Lotus (Nelumbo Nucifera Gaertn.) in Streptozotocin Induced Mice

“…DM is the most common multifactorial chronic disease and known as a very common metabolic disorder of human endocrine systems such as abnormal insulin production or metabolism and chronic hyperglycemia [17,18]. In the present study of antidiabetic activity of various lotus leaf extract (hexane, ethyl acetate, and ethanol) was evaluated by STZ induces diabetic mice.…”

Evaluation of Antidiabetic and Antioxidant Activities of Fruit Pulp Extracts of Cucurbita moschata Duchesne and Cucurbita maxima Duchesne

“…Antioxidant compounds could increase the number of pancreatic β cells by enhancing the repair and restoration of these cells. Moreover, flavonoids could protect DNA from oxidative damage to lessen the problem in β cells [ 60 – 62 ].…”