Comparative Efficacy of Piperazine Citrate, Levamisole and Pineapple Leaves Extract Against Naturally Infected Ascariasis in Indigenous Chickens

Hoque, M. E.; Mostafa, Mohamed M.; Awal, MA; Choudhury, ME; Hossain, Mohammad Amjad; Alam, Md. Ferdous

doi:10.3329/bjvm.v4i1.1521

Cited by 7 publications

(6 citation statements)

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“…The mortality index was close to that of mebendazole proving that although not statistically different, the plant has anthelmintic properties. This is in agreement with Hoque et al (2006) who reported decrease in ascariasis parasites due to oral administration of pineapple leaf extracts to indigenous chickens. This entails that medicinal plants can effectively reduce worm burden in village chickens.…”

Section: Discussionsupporting

confidence: 93%

“…During the second and third hour, motility findings show that H. gallinarum worms succumbed to the anti-parasitic effects. Inhibition of worm motility is a crucial process for mortality of worms and hence anthelmintic property of a medicinal plant or anthelmintic drug, thereby relieving the animal from parasite infections (Hoque, Mostofa, Awal, Choudhury, Hossain, & Alam, 2006). The ability of A. sisalana extract (14.5 mg/mL) to exert high worm inhibition motility at 12-h interval shows that the plant has some anthelmintic properties.…”

Section: Discussionmentioning

confidence: 99%

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In vitro Anthelmintic Efficacy of Medicinal Plants against Heterakis gallinarum in Village Chickens

Mwale¹,

Masika²

2015

JAS

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Heterakis gallinarum impedes the productivity of village chickens and hence their socio-economic contribution to rural communties. Smallholder farmers are endowed with vast indigenous knowledge for controlling H. gallinarum and they predominantly use Aloe ferox, Agave sisalana and Gunnera perpensa. However, their anthelminthic efficacy is unknown. Therefore, our objective was to determine the in vitro anthelmintic efficacy of A. ferox, A. sisalana and G. perpensa against H. gallinarum. Heterakis gallinarum worms were recovered from caeca of 20 village chickens. Ten worms were randomly introduced in each of the 42 petri-dishes. Treatments were positive control (distilled water), negative control (mebendazole) and A. ferox, A. sisalana and G. perpensa aqueous extracts at dosage of 7.25, 14.5, 29 and 58 mg/mL. The procedure was done in triplicate. Worm motility and mortality indices were calculated. Among plant, A. sisalana (14.5 mg/mL) had the greatest (80%) worm motility inhibition at 12-h interval (p < 0.05) and the greatest worm mortality index (80%) showing that the plant has anthelmintic properties. Seventy percent of worms were recovered after 48 h following treatment with A. ferox (58 mg/mL). Agave sisalana (14.5 mg/mL) was the most efficient plant in reducing motility and causing mortality of H. gallinarum in vitro. Findings are useful to resource-constrained farmers who use crude extracts, to select the best plant and to pharmaceutical companies for manufacturing anthelmintic drugs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

In vitro Anthelmintic Efficacy of Medicinal Plants against Heterakis gallinarum in Village Chickens

Mwale¹,

Masika²

2015

JAS

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“…The histomonas can cause liver damage leading to protein deficiency and hence anaemia (Sentíes-Cué et al, 2009), therefore synthesis and maintenance of haematological values within the reference range, is crucial as necessitated by the studied plants. The results are, however, contrary to those of Hoque et al (2006) where haemoglobin and packed cell volume (haematocrit) increased in the study for testing the anthelmintic efficacy of pineapple leaf extract against natural ascariasis in indigenous chickens.…”

Section: Discussioncontrasting

confidence: 88%

“…Blood was collected pre-feeding in triplicate per treatment on day 0, 7 and 14 using a syringe and a needle from the wing vein (Akhtar and Riffat, 1985;Hoque et al, 2006). Heparinised vacutainer tubes were used for the collection of blood for FBC while non-heparinised vacutainer tubes were used to collect blood for serum biochemical assay (AST and ALT).…”

Section: Blood Parameter Analysesmentioning

confidence: 99%

Effect of Medicinal Plants on Haematology and Serum Biochemical Parameters of Village Chickens Naturally Infected with <i>Heterakis gallinarum</i>

Mwale

Masika

Materechera

2014

Bangl. J. Vet. Med.

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The effects of Aloe ferox, Agave sisalana and Gunnera perpensa on haematological and biochemical parameters of village chickens naturally infected with Heterakis gallinarum were evaluated. One hundred and twelve mature village chickens were randomly allotted into 14 groups of 8 chickens. Group 1 and 2 were orally administered 1 mL distilled water for 4 consecutive days and 1 mL mebendazole (once), respectively. Groups 3-6 received 1 mL orally of aqueous leaf extract of A. ferox for 4 consecutive days, groups 7-10 A. sisalana and 11-14 G. perpensa in graded doses of 50, 100, 200 and 400 mg/kg, respectively. Blood was collected into vacutainers in triplicate, from the wing veins on day 0, 7 and 14. Data was analysed using general linear model of statistical analyses system. Chickens offered A. sisalana (200 mg/kg) had highest alanine transaminase (ALT) value (P < 0.05; 7.50 ± 0.406 U/l) on day 0. On day 7 and 14, there was no difference in ALT values (P >0.05). Significant differences among plants for aspartate transaminase on day 0, 7 and 14 were observed. Mean corpuscular haemoglobin concentration and mean corpuscular volume were maintained within the reference range. From day 0 to 14, haematocrit was reduced for chickens on G. perpensa (50, 100 and 400 mg/kg), A. ferox (100 and 400 mg/kg) and A. sisalana (50, 100, 200 and 400 mg/kg). Haemoglobin was out of range on day 0 and improved to be within the range on day 7 and 14. The medicinal plants enabled normal synthesis and functioning of haematological and biochemical parameters of village chickens and were maintained within the expected reference ranges. These plants are crucial phytomedicines for treating H. gallinarum infestations in village chickens.DOI: http://dx.doi.org/10.3329/bjvm.v12i2.21263Bangl. J. Vet. Med. (2014). 12 (2): 99-106

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“…"Blood was collected pre-feeding in triplicate per treatment on day 0, 7 and 14 using a syringe and a needle from the wing vein" [11]. "Heparinized tubes were used for the collection of blood for FBC while non-heparinized tubes were used to collect blood for serum biochemical assay (AST and ALT).…”

Section: Blood Parameter Analysesmentioning

confidence: 99%

Hematological and Hypoglycemic Effects of Ethanolic Extract of Annona muricata Ripe Fruits Pulp on Streptozotocin-induced Diabetes in Rats: In vivo and In silico Studies

Akinlolu

Fatoki

Momodu

2023

JOCAMR

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Diabetes mellitus has been a metabolic disorder characterized by interferences in the breakdown of carbohydrate, lipid, and protein as a result of insulin deficiency. Great efforts are ongoing in understanding and management of diabetes, and disease related complication. In this work, an attempt was made to study the hematological and hypoglycemic effects of Annona muricata ripe fruits pulp in Streptozotocin (STZ)-induced diabetic rats and validates its traditional claim. The forty-eight (48) Albino rat were divided into six groups which include normal, tests and controls. The diabetes–induced rats were fed orally with A. muricata ripe fruits pulp extract in concentrations of 750 mg, 1000 mg, and 2000 mg respectively. The results showed that the extract caused fasting blood sugar glucose levels to remarkably reduced to near normal. Hematological studies revealed that there were improvements in the hematological indices tested groups when compare with diabetes normal group. The molecular docking results indicate that the phytochemicals in A. muricata ripe fruit pulp have more affinity for aldose reductase followed by alpha-amylase and then alpha-glucosidase, and that montecristin, epoxymurin-A, dicaffeoylquinic acid, and kaempferol 3-O-rutinoside show higher affinity to the three targets than acarbose. These results indicate that ripe fruits pulp of A. muricata possesses a strong hypoglycemic effect in STZ–induced diabetic rats, thus supporting its traditional use in the management of diabetes mellitus.

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Comparative Efficacy of Piperazine Citrate, Levamisole and Pineapple Leaves Extract Against Naturally Infected Ascariasis in Indigenous Chickens

Cited by 7 publications

References 0 publications

In vitro Anthelmintic Efficacy of Medicinal Plants against Heterakis gallinarum in Village Chickens

In vitro Anthelmintic Efficacy of Medicinal Plants against Heterakis gallinarum in Village Chickens

Effect of Medicinal Plants on Haematology and Serum Biochemical Parameters of Village Chickens Naturally Infected with <i>Heterakis gallinarum</i>

Hematological and Hypoglycemic Effects of Ethanolic Extract of Annona muricata Ripe Fruits Pulp on Streptozotocin-induced Diabetes in Rats: In vivo and In silico Studies

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