Comparative Effects of Milk and Soymilk on Bone Loss in Adult Ovariectomized Osteoporosis Rat

Taguchi, Hirotaka; Chen, Huayue; Yano, Ryuichiro; Shoumura, Shízuko

doi:10.2535/ofaj.83.53

Cited by 11 publications

(10 citation statements)

References 22 publications

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“…The present study showed that rats experiencing osteoporosis brought about an exceptionally huge increment in PTH levels contrasted with the control gathering. The acquired results are in accordance with Taguchi et al, (2006).…”

Section: Discussionsupporting

confidence: 84%

Effect of Moringa Leaves and Seeds on Osteoporosis in Rats

Habib

Al-Moalem

2018

Journal of Food and Dairy Sciences

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Osteoporosis (OP) speaks to most regular metabolic bone maladies. This study was conducted to study the impact of Moringa oleifera leaves and seeds and their blends on osteoporosis in rats. Thirty five adult female albino of rats, of (180 ± 10 g) were divided into five groups, the first group, negative control group (-ve) and fed on basal diet only, the other four groups (7 rats each) were fed on basal diet containing 100 mg Prednisone Acetate as source of glucocorticoid/ kg diet to induce osteoporosis for two weeks. One group of them was served as a positive control group, the other three groups were fed on prednisone acetate diets containing dried moringa leaves (2.5%), moringa seeds (2.5%) and 2.5% of their combination at (1:1), respectively. Blood samples and femur bones were collected for estimating both serum and bone markers of osteoporosis. The results indicated that, supplementation with Moringa oleifera leaves and seeds and their combinations significantly increased (P<0.05) serum Ca and P in osteoporotic rats. There was significant increase (P<0.05) in serum free thyroxin (T4) and a significant decrease (P<0.05) in parathormone (PTH) in osteoporotic rats. Femur bone mineral density (BMD) were also significantly increased. The present examination suggested utilizing Moringa oleifera leaves and seeds and their blends as a good anti-osteoporotic activity.

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Section: Discussionsupporting

confidence: 84%

Effect of Moringa Leaves and Seeds on Osteoporosis in Rats

Habib

Al-Moalem

2018

Journal of Food and Dairy Sciences

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“…The present outcomes uncovered that rats experiencing osteoporosis brought about an exceptionally huge increment in PTH levels contrasted with the control gathering. The acquired outcomes are in accordance with Taguchi et al, (2006) and Zhu et al, (2012). Narayana et al, (2012) announced that estrogen lack instigates bone resorption by discharging calcium into the extracellular space, which thus smothers PTH emission, calcitriol combination, and intestinal retention of calcium in cancellous bone prompting general bone misfortune and decimation of neighborhood design and decreased bone quality bringing about osteoporosis (Sachdeva et al, 2005 andJustesen et al, 2006).…”

Section: Discussionmentioning

confidence: 75%

The Possible Protective Role of Powder Cuttlefish Bone, Crabshell and Eggshell on Osteoporotic Rats

Negm

2018

Journal of Food and Dairy Sciences

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Bone mass declines alongside maturing, particularly for ladies after menopause as a result of diminishing estrogen emission together with low calcium consumption. This examination was directed to examine the impact of powdered cuttlebone, crab shell and eggshell, on female rats with induced osteoporosis. Fifty adult female albino rats, of (200 ± 10 g) were haphazardly divided into five groups, the first group, negative control group (-ve) fed on basal diet only, the other four groups (10 rats each) were fed on basal diet containing 100 mg prednisone acetate as source of glucocorticoid/ kg diet to induce osteoporosis for two weeks. One group of them was selected as a positive control group, the other three groups were fed on prednisone acetate diets containing powder of cuttlebone, crabshell and eggshell, at the level of 2.5% individually. Blood samples and femur bones were gathered for measure both serum and bone markers of osteoporosis. The results indicated that, supplementation with powder of cuttlebone, crabshell and eggshell significantly (P<0.05) increase of Ca and P in serum of osteoporotic rats. There were a significant increment in serum free thyroxin (T4) and a significant decrease in parathyroid hormone (PTH). Femur bone mineral content (BMC) and bone mineral density (BMD) were likewise increased as compared to positive control group. In addition, liver functions were significantly (P<0.05) improved compared to the positive control group, while serum lipid profiles were significantly decreased. These results recommend that sustaining postmenopausal rats with osteoporosis on diets supplemented with powder of cuttlebone, crab shell and eggshell instigated an enemy of osteoporotic impact. This impact may be due to upgrade of bone arrangement and direction of some metabolic hormones which control calcium. Therefore, it could be recommended using powder of cuttlebone, crabshell and eggshell for postmenopausal women suffering from osteoporosis.

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“…Compared to the control ovariectomized rats, soy fed ovariectomized rats have been found to have higher levels of trabecular bone volume, insulin-like growth factorI (IGF-I), serum estradiol levels, and serum osteocalcin [25–26]. In addition, there were lower levels of serum parathyroid hormone, trabecular area of resorption surface and bone resorption marker urinary deoxypyridinoline (DPD) among the soy milk fed rats compared to the control ovariectomized rats [25–26]. …”

Section: Discussionmentioning

confidence: 99%

Soy milk and dairy consumption is independently associated with ultrasound attenuation of the heel bone among postmenopausal women: the Adventist Health Study–2

et al. 2011

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Soy milk has become a popular substitute for dairy milk with important health claims. We hypothesized that soy milk, based on its nutrient composition, was comparable to dairy products and, therefore, beneficial for bone health. To test this hypothesis, we examined the benefit of soy milk and dairy products intake on bone health using broadband ultrasound attenuation (BUA) of the calcaneus. Post-menopausal Caucasian women (n=337) who had completed a lifestyle and dietary questionnaire at enrollment into the AHS-2 had their calcaneal BUA measured two years later. The association between osteoporosis (defined as a T-score <−1.8) and some dietary factors (soy milk, dairy) and selected lifestyle factors was assessed using logistic regression. In a multivariable model adjusted for demographics, hormone use and other dietary factors, osteoporosis was positively associated with age (OR= 1.08, 95%CI: 1.06–1.12) and inversely associated with BMI (OR=0.91, 95% CI: 0.86–0.97) and current estrogen usage (OR=0.27, 95% CI: 0.13–0.56). Compared to women who did not drink soy milk, women drinking soy milk once a day or more had 56% lower odds of osteoporosis (OR= 0.44, 95%CI: 0.20–0.98 (ptrend=0.04). Women whose dairy intake was once a day or more had a 62% reduction in the likelihood of having osteoporosis (OR=0.38, 95%CI: 0.17–0.86)(ptrend=0.02) compared to women whose dairy intake was less than twice a week. Among individual dairy products, only cheese showed an independent and significant protection (OR=0.28, 95%CI: 0.12–0.66)(ptrend=0.004) for women eating cheese more than once per week vs. those who ate cheese less than once a week. We concluded that osteoporosis is inversely associated with soy milk intake to a similar degree as dairy intake after accounting for age, BMI, and estrogen usage.

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Comparative Effects of Milk and Soymilk on Bone Loss in Adult Ovariectomized Osteoporosis Rat

Cited by 11 publications

References 22 publications

Effect of Moringa Leaves and Seeds on Osteoporosis in Rats

Effect of Moringa Leaves and Seeds on Osteoporosis in Rats

The Possible Protective Role of Powder Cuttlefish Bone, Crabshell and Eggshell on Osteoporotic Rats

Soy milk and dairy consumption is independently associated with ultrasound attenuation of the heel bone among postmenopausal women: the Adventist Health Study–2

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