Effect of Moringa Leaves and Seeds on Osteoporosis in Rats

Abstract

Osteoporosis (OP) speaks to most regular metabolic bone maladies. This study was conducted to study the impact of Moringa oleifera leaves and seeds and their blends on osteoporosis in rats. Thirty five adult female albino of rats, of (180 ± 10 g) were divided into five groups, the first group, negative control group (-ve) and fed on basal diet only, the other four groups (7 rats each) were fed on basal diet containing 100 mg Prednisone Acetate as source of glucocorticoid/ kg diet to induce osteoporosis for two weeks. One group of them was served as a positive control group, the other three groups were fed on prednisone acetate diets containing dried moringa leaves (2.5%), moringa seeds (2.5%) and 2.5% of their combination at (1:1), respectively. Blood samples and femur bones were collected for estimating both serum and bone markers of osteoporosis. The results indicated that, supplementation with Moringa oleifera leaves and seeds and their combinations significantly increased (P<0.05) serum Ca and P in osteoporotic rats. There was significant increase (P<0.05) in serum free thyroxin (T4) and a significant decrease (P<0.05) in parathormone (PTH) in osteoporotic rats. Femur bone mineral density (BMD) were also significantly increased. The present examination suggested utilizing Moringa oleifera leaves and seeds and their blends as a good anti-osteoporotic activity.

Effect of Soybean, Virgin Coconut and Moringa oleifera Seed Oils on the Propylthiouracil Induced Hypothyroidism in Rats

“…Sheikh et al (2014) reported that both ethanol moringa leaves and seeds extracts reduced arsenicinduced elevation of liver activities. These findings are in accordance with Nada et al (2015), Toppo et al (2015) and Habib & Al-Moalem (2018).…”

The anti-osteoporotic effect of Moringa oleifera leaves extract on glucocorticoids-induced jawbone osteoporosis in Albino rats

“…Habib and Al-Moalem had similar results where BMD significantly increased in a glucocorticoid model of osteoporotic rats fed on dried moringa leaves. This could be attributed to the minerals found in MO, which possess both a curative and preventive role against osteoporsis [32].…”