Comparative effects of high-dose atorvastatin versus moderate-dose rosuvastatin on lipid parameters, oxidized-LDL and inflammatory markers in ST elevation myocardial infarction

Aydın, Mehmet Faruk; Aygül, Nazif; Altunkeser, Bülent Behlül; Ünlü, Ali; Taner, Alpaslan

doi:10.1016/j.atherosclerosis.2015.02.003

Cited by 30 publications

(30 citation statements)

References 34 publications

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“…High‐density lipoprotein combines with CHOL and forms HDL‐C, which can convey cholesterol from various tissues back to liver; conversely, LDL‐C conveys cholesterol from liver to various tissues (Brown, ; Yun, Mai, Zhang, & Xu, ). However, LDL will be oxidized as oxidized low‐density lipoprotein (OX‐LDL) that can make cholesterol stockpile in arterial walls causing arteriosclerosis easily when lots of peroxide exist in vivo (Aydin, Aygul, Altunkeser, Unlu, & Taner, ; Granger & Weaver, ; Shin, Edelberg, & Hong, ). In the study, cholesterol was attached to arterial walls with OX‐LDL, forming blood cake, because of ingesting fish oil with high oxidation degree.…”

Section: Discussionmentioning

confidence: 99%

Effects of fish oil with difference oxidation degree on growth performance and expression abundance of antioxidant and fat metabolism genes in orange spotted grouper,Epinephelus coioides

et al. 2018

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The present study was designed to assess the effects of fish oil with different oxidation degree on growth performance, serum biochemistry parameters and expressive abundance of oxidative stress and fat metabolism genes of orange spotted grouper Epinephelus coioides. The oxidized fish oil was conducted as follows: storage temperature: 4°C, ambient temperature (AT, [31.5 ± 3.5]°C); storage time: 45, 90, 135 days; antioxidant contents: 30 mg/kg (ethoxyquin [EQ]), 300 mg/kg Higher EQ (HEQ). According to the different treated conditions, 14 kinds of fish oil with different oxidation degree were obtained: T F+EQ [positive control (fresh oil + EQ)],T AT+135d+EQ , T AT+135d+HEQ . Groupers were fed isonitrogenous and isolipidic diets containing 14 kinds of fish oil for 8 weeks, respectively. The results showed that survival, weight gain rate and thermal growth coefficient decreased as oxidation degree of dietary fish oil increased (p < 0.05). Higher serum total protein, triglyceride and glucose were observed with ascending oxidation degree of fish oil (p < 0.05). The genes expression levels of catalase, superoxide dismutase and glutathione peroxidase were up-regulated with dietary oxidized level increasing (p < 0.05). In addition, the similar status also appeared in expression of peroxisome proliferator-activated receptor gamma (PPARγ), hormone-sensitive lipase (HSL) and fatty acid synthase (FAS) genes. In conclusion, the fish oil would show negative influence on the fish health until peroxide value and p-anisidine value in oil exceed 12.96 meq/kg and 20.89. The best storage condition for fish oil is 4°C, 45 days and 30 mg/kg EQ which could keep fish oil available property to grouper. K E Y W O R D Santioxidant, fat metabolism, grouper, growth, oxidized fish oil

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Section: Discussionmentioning

confidence: 99%

Effects of fish oil with difference oxidation degree on growth performance and expression abundance of antioxidant and fat metabolism genes in orange spotted grouper,Epinephelus coioides

et al. 2018

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“…Further, from week 24 to 48, LDL increased 13% in the rosuvastatin group which is a possible explanation for why the reduction in oxLDL was not sustained. Short term, several studies have shown that statins reduce oxLDL outside of HIV [26,27,42–49]; however, few have follow-up to 48 weeks and the results are mixed [50–52]. In a study of adults with ischemic cardiomyopathy, the atorvastatin dose appeared to play a role in oxLDL reduction over 48 weeks [50].…”

Section: Discussionmentioning

confidence: 99%

Changes in oxidized lipids drive the improvement in monocyte activation and vascular disease after statin therapy in HIV

Hileman

Turner

Funderburg

et al. 2016

Aids

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Background Oxidative stress plays a significant role in atherosclerosis development. HIV infection has been linked with heightened cardiovascular disease risk. HMG-CoA reductase inhibitors may reduce oxidative stress and subsequently subclinical vascular disease in HIV. Design/methods This is a randomized, placebo-controlled trial to evaluate the effect of rosuvastatin in HIV-infected adults on stable antiretroviral therapy with low-density lipoprotein less than 130 mg/dl and increased inflammation or T-cell activation on subclinical vascular disease. Changes over 48 weeks in oxidative stress markers, oxidized low-density lipoprotein (oxLDL) and F2-isoprostane/creatinine ratio (F2-Iso-P/Cr), were compared between groups. Spearman correlation and multivariable linear regression were used to evaluate relationships between changes in markers of oxidative stress, inflammation and monocyte activation and carotid intima media thickness (CIMT). Results One hundred and forty-seven adults enrolled (72 to rosuvastatin and 75 to placebo). In the rosuvastatin group, oxLDL decreased significantly over 24 weeks compared to placebo [mean absolute change in log-oxLDL for rosuvastatin −0.2 ± 0.468 log U/l (P < 0.001 within-group) vs. placebo −0.018 ± 0.456 log U/l (P = 0.83 within-group); P = 0.004 between groups] and this change was linked with changes in soluble CD14 and proportion of patrolling monocytes (CD14dimCD16+). Although oxLDL levels increased after initially declining and were not different from placebo at week 48, the early improvement in oxLDL was associated with improved CIMT at week 48. Changes in F2-IsoP/Cr were not significant between groups. Conclusion Rosuvastatin decreases oxLDL levels early after initiation and is associated with decreased monocyte activation. Early improvement in oxLDL is linked with improved CIMT in treated HIV infection.

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“…Similar results were found in the study of Aydin et al . where both rosuvastatin and atorvastatin lowered the inflammation markers in STEMI patients, whereas in another study, a loading dose of atorvastatin was found to reduce inflammatory response and myocardial dysfunction in STEMI patients [67, 68]. The inflammatory response has also been found to be reduced in percutaneous coronary intervention when a short-term high-dose atorvastatin treatment is administered [69].…”

Section: Clinical Evidence Of Statins’ Anti-inflammatory Effectmentioning

confidence: 99%

The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature

Diamantis

Kyriakos

Quiles-Sánchez

et al. 2017

CCR

166

108

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Background:Statins have long been used for the protection against coronary artery disease (CAD). Their beneficial effect apart from cholesterol reduction lies in their pleiotropic properties. Emerging evidence from laboratory studies and clinical trials as well have pointed out the pivotal role of inflammation on the initiation and exacerbation of atherosclerosis; a major cause of CAD. Inflam-mation markers such as high sensitivity C-reactive protein and adhesion molecules are shown to in-crease in CAD patients and are used as prognostic tools. It is well known that statins can actually re-duce the circulating levels of these agents slowing therefore the inflammatory process; interestingly not all types have the same outcome.Conclusion:The anti-inflammatory effect of statins on the formation of atherosclerotic plaque and the function of endothelial cells is thus of particular importance as these agents can actually ameliorate CAD prognosis

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Comparative effects of high-dose atorvastatin versus moderate-dose rosuvastatin on lipid parameters, oxidized-LDL and inflammatory markers in ST elevation myocardial infarction

Cited by 30 publications

References 34 publications

Effects of fish oil with difference oxidation degree on growth performance and expression abundance of antioxidant and fat metabolism genes in orange spotted grouper,Epinephelus coioides

Effects of fish oil with difference oxidation degree on growth performance and expression abundance of antioxidant and fat metabolism genes in orange spotted grouper,Epinephelus coioides

Changes in oxidized lipids drive the improvement in monocyte activation and vascular disease after statin therapy in HIV

The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature

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