Comparative Effect of Flaxseed Oil and Fish Oil in Acetic Acid- Induced Colitis in Rats

Abstract

Objectives: The aim of the present study was to evaluate the possible protective effect of flaxseed oil and to compare this effect with fish oil in experimental ulcerative colitis (UC).Methods: Rats were equally divided into five groups of six animals each. Sham control group (corn oil, 1 ml), acetic acid group (normal saline, 1 ml), flaxseed oil group (FSO, 1 ml), fish oil group (FO, 1 ml) and mesalamine-treated group (3 ml ) as a positive control. All drugs were administered intrarectally (IR). One hour following treatment in the acetic acid group, FSO group, FO group and mesalamine group, 1 ml of 4% acetic acid was introduced as an enema. Rats were sacrificed after 24 hrs and histopathological scores of the all colonic specimens were assessed by microscope. Colonic weight/length ratio was also evaluated.Results: Microscopical improvement as manifested by the reduction in the inflammatory score and normalization of intestinal mucosal architecture was observed in fish oil pretreated rats compared to acetic acid group but there was no significant difference in flaxseed oil pretreated group. The decrease in weight/length ratio was statistically significant in fish oil-treated group compared with acetic acid group, but there was no significant difference between flaxseed oil-treated and acetic acid group.Conclusion: The results of this study suggest that fish oil but not flaxseed oil could ameliorate the mucosal damage in experimentally induced ulcerative colitis in rats when given in the form of an enema.

Linhaça: Composição, Compostos Bioativos E Efeitos Fisiológicos Na Saúde Humana

“…Apesar dos resultados iniciais promissores, é importante ressaltar que ainda são escassos os estudos com linhaça nas DIIs, especialmente os relacionados à microbiota intestinal. Além disso, os estudos com roedores realizados por DUGANI et al (2012), ZAREPOOR et al (2014), MÄÄTTÄNEN et al (2018 no risco e mortalidade para CM, especialmente em mulheres em estágio pós-menopausa (BUCK et al, 2010;FLOWER et al, 2014). Adicionalmente, ensaios clínicos associam a suplementação com linhaça com a regulação nos níveis circulantes e urinários de hormônios sexuais ( HAGGANS et al, 1999;CHANG et al, 2019).…”

Linhaça e azeite de oliva extra-virgem: composição nutricional e efeitos na colite ulcerativa

“…Os autores comprovaram ter o OL, em comparação ao óleo de milho, efeito menos inflamatório no intestino [17]. No entanto, quando em comparação ao óleo de peixe, Dugani, Elhelawi, Edrah [36], não encontraram resultados positivos para o OL; os autores induziram a CU aguda, por ácido acético, em ratos Wistar, e administraram, via enema, óleos de peixe e linhaça, encontrando efeitos anti-inflamatórios apenas para o primeiro. Especula-se que o óleo de peixe possa ter efeitos melhores que o OL, e que o óleo de milho seja o mais prejudicial, no entanto, devido a falta de padrão entre os estudos [17,36], tais conclusões fazem-se precipitadas.…”