Comparative effect of carbarylon rat reproduction and guinea pig teratology when fed either in the diet or by stomach intubation*1

Carbaryl: A Literature Review

“…Reproductive measures including infertility, fetotoxieity, teratogenesis, and mutagenesis have been reported on various animal species. Responses in fish, birds, and mammals are varied and WEIL et al (1973) concluded that reproductive effects produced at high dosage levels in laboratory animals were not likely to affect man under normal conditions. A major concern for pesticides is their potential carcinogenicity.…”

“…The prostate gland of rats dosed with 8.5, 17, and 34 mg of carbaryl/kg daily for 5 days had no significant changes (THOMAS et al 1974). Differences existed between dietary and oral administration of carbaryl upon cholinesterase inhibition, mortality, and reproductive efIects in laboratory animals (WEIL et al 1973). A three-generation study with rats used maximum daily dos es of 200 mg/kg body weight and maximum oral dose of 100 mg/kg body weight.…”

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

“…Weil et al (1972Weil et al ( , 1973 giving Carbaryl per os in the diet (2.5 to 200 mg/ kg/ day) or by intubation (3 to 100 mg/ kg) observed no embryotoxic or teratogenic effects. In the Osborne-Mendel strain, rats receiving Carbaryl in the diet (5000 ppm) showed a slight decrease in litter size.…”

“…In the same test, male rats of the second generation treated daily at doses of 25, 100, and 200 mg/ kg in their diet or 3.25 and 100 mg/ kg per intubation gave negative results (Weil et al, 1973).…”

Dose and Time Determining, and Other Factors Influencing, Toxicity

“…The differential in response from two different modes of oral administration, diet versus gavage, was evaluated by Weil et al (1973). Rats in a reproduction study and guinea pigs in a teratology study were given carbaryl by one of the modes of oral exposure.…”