Comparative Effect of Animal Prolactins and Human Growth Hormone (HGH) in Hypopituitary Children

Blizzard, Robert M.; Drash, Allan L.; Jenkins, Melvin E.; Spaulding, John S.; Glick, Aaron; Weldon, Virginia V.; Powell, Gerald F.; Raiti, Salvatore

doi:10.1210/jcem-26-8-852

Cited by 14 publications

(2 citation statements)

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“…Although the present results do not allow a conclusion to be drawn on this question, one may speculate a role of the amino acids in stimulating Prl secretion, which in turn, along with GH and Ins, may act in the conversion of the amino acids into tissue proteins. This suggestion seems more tenable when viewed in connection with previous reports that Prl administration results in increased nitrogen retention and general metabolic effects similar to those reported for GH (9)(10)(11)(12). In addition, McAtee and Trenkle (8) have recently observed that plasma levels of Prl are decreased during fasting and are increased after feeding and by arginine infusion.…”

Section: Discussionsupporting

confidence: 58%

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Davis

1972

Endocrinology

108

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The effects of amino acid infusions on plasma levels of prolactin (Prl), growth hormone (GH) and insulin (Ins) in sheep were studied using specific double antibody radioimmunoassay systems.The infusion of arginine (0.5 g/kg), leucine (0.2 g/kg) and phenylalanine (0.3 g/kg) into the carotid artery (via an indwelling cannula) of mature, anestrus ewes, resulted in a significant increase in plasma levels of Prl. Arginine and leucine also stimulated significant increases in plasma GH and insulin levels, while the phenylalanine treatment significantly increased plasma levels of insulin but not GH. The intrajugular injection of arginine (0.5 g/kg) into immature male and female sheep also produced significant increases in Prl, GH and insulin.It was also observed that physically or psychologically stressful factors may produce a significant elevation in plasma levels of Prl, but do not appear to affect GH secretion in sheep. (Endocrinology 9 1 : 205, 1972)

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Section: Discussionsupporting

confidence: 58%

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Davis

1972

Endocrinology

108

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“…The present observation of serum NSILA-S in hyperprolactinaemia suggests that, in the presence of normal G H secretion, prolactin hypersecretion is not able to stimulate further NSILA-S production, whereas prolactin hypersecretion appears effective in the absence of GH. Considerable structural homology exists between prolactin and G H (Niall et a/., 1973), which is a known inducer of NSILA-S (Franklin et al, 1978), and prolactin has a weak somatotrophic action in man (McGarry & Beck, 1962;Blizzard et al, 1966). Furthermore prolactin stimulates the rat liver to produce somatomedin when perfused in vitro (Francis & Hill, 1975).…”

Section: Discussionmentioning

confidence: 99%

Endocrine Influences on Serum Acid‐ethanol Soluble Non‐suppressible Insulin‐like Activity (Nsila‐s)

Franklin

Rennie

Burger

et al. 1980

Clinical Endocrinology

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Serum levels of the acid-ethanol soluble component of non-suppressible insulin-like activity (NSILA-S) have been measured by bioassay in patient with hyperprolactinaemia, hypothyroidism, thyrotoxicosis and diabetes mellitus, and in normal subjects administered prednisone, oestrogens of androgens. Hyperprolactinaemia per se did not influence serum NSILA-S, however when GH was deficient prolactin hypersecretion may have maintained serum NSILA-S. Thyroid hormones, insulin and steroids did not appear to influence serum NSILA-S. These results suggest that regulation of the serum concentration of NSILA-S is not a common effector mechanism by which these hormones influence statural growth in man.

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Biological Effects of Non‐Primate Prolactin and Human Placental Lactogen

McGarry

Beck

1972

Ciba Foundation Symposium ‐ Lactogenic Hormones

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Comparative Effect of Animal Prolactins and Human Growth Hormone (HGH) in Hypopituitary Children

Cited by 14 publications

References 0 publications

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Endocrine Influences on Serum Acid‐ethanol Soluble Non‐suppressible Insulin‐like Activity (Nsila‐s)

Biological Effects of Non‐Primate Prolactin and Human Placental Lactogen

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