The mechanism of action of an extract of intestinal mucosa that accelerates the disposal of glucose given intravenously in normal man was investigated. The active material is biologically distinguishable from pancreozymin, and its effects cannot be attributed to insulin, insulin-like activity, glucagon or amino acids in the preparation. The extract enhances the increase in blood-insulin concentration which occurs in response to the intravenous infusion of glucose in normal man and which has been compared with that following ingestion of glucose. No response was demonstrable in insulin-treated juvenile-onset diabetes, and it is suggested that the extract acts in normal subjects by stimulating the jrelease of endogenous insulin. It is concluded that an insujln-aecretagogue, derived from the small intestine, may be concerned in the response to ingested glucose, and that such, an agent may be present in the active extract.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.